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Impact of local versus global ligand density on cellular adhesion

αvβ3 integrin-mediated cell adhesion is crucially influenced by how far ligands are spaced apart. To evaluate the impact of local ligand density versus global ligand density of a given surface, we used synthetic micronanostructured cell environments with user-defined ligand spacing and patterns to i...

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Main Authors: Deeg, Janosch A. (Author) , Louban, Ilia (Author) , Aydin, Daniel (Author) , Selhuber-Unkel, Christine (Author) , Kessler, Horst (Author) , Spatz, Joachim P. (Author)
Format: Article (Journal)
Language:English
Published: March 22, 2011
In: Nano letters
Year: 2011, Volume: 11, Issue: 4, Pages: 1469-1476
ISSN:1530-6992
DOI:10.1021/nl104079r
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/nl104079r
Verlag, lizenzpflichtig, Volltext: https://pubs.acs.org/doi/10.1021/nl104079r#
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Author Notes:Janosch A. Deeg, Ilia Louban, Daniel Aydin, Christine Selhuber-Unkel, Horst Kessler, and Joachim P. Spatz

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