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Impact of local versus global ligand density on cellular adhesion

αvβ3 integrin-mediated cell adhesion is crucially influenced by how far ligands are spaced apart. To evaluate the impact of local ligand density versus global ligand density of a given surface, we used synthetic micronanostructured cell environments with user-defined ligand spacing and patterns to i...

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Bibliographic Details
Main Authors: Deeg, Janosch A. (Author) , Louban, Ilia (Author) , Aydin, Daniel (Author) , Selhuber-Unkel, Christine (Author) , Kessler, Horst (Author) , Spatz, Joachim P. (Author)
Format: Article (Journal)
Language:English
Published: March 22, 2011
In: Nano letters
Year: 2011, Volume: 11, Issue: 4, Pages: 1469-1476
ISSN:1530-6992
DOI:10.1021/nl104079r
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/nl104079r
Verlag, lizenzpflichtig, Volltext: https://pubs.acs.org/doi/10.1021/nl104079r#
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Author Notes:Janosch A. Deeg, Ilia Louban, Daniel Aydin, Christine Selhuber-Unkel, Horst Kessler, and Joachim P. Spatz
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Summary:αvβ3 integrin-mediated cell adhesion is crucially influenced by how far ligands are spaced apart. To evaluate the impact of local ligand density versus global ligand density of a given surface, we used synthetic micronanostructured cell environments with user-defined ligand spacing and patterns to investigate cellular adhesion. The development of stable focal adhesions, their number, and size as well as the cellular adhesion strength proved to be influenced by local more than global ligand density.
Item Description:Gesehen am 03.05.2022
Physical Description:Online Resource
ISSN:1530-6992
DOI:10.1021/nl104079r

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