A fatal complication in a patient with heparin-induced thrombocytopenia type II re-exposed to heparin
The heparin-induced thrombocytopenia type II is a rare but important drug related complication associated with thrombocytopenia and thrombosis. We report on a patient with elective revision of the total hip arthroplasty. Preoperatively for nineteen days, the patient received unfractionated heparin 5...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 September 1999
|
| In: |
European journal of orthopaedic surgery & traumatology
Year: 1999, Volume: 9, Issue: 3, Pages: 205-207 |
| ISSN: | 1432-1068 |
| DOI: | 10.1007/BF00542596 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/BF00542596
|
| Author Notes: | U. Hoffmann, G. Huhle, K. Haseroth, D.L. Heene, J. Harenberg |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1801016186 | ||
| 003 | DE-627 | ||
| 005 | 20230427140239.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220505s1999 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/BF00542596 |2 doi | |
| 035 | |a (DE-627)1801016186 | ||
| 035 | |a (DE-599)KXP1801016186 | ||
| 035 | |a (OCoLC)1341459633 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hoffmann, Ursula |d 1962- |e VerfasserIn |0 (DE-588)115587098 |0 (DE-627)691432406 |0 (DE-576)289964113 |4 aut | |
| 245 | 1 | 2 | |a A fatal complication in a patient with heparin-induced thrombocytopenia type II re-exposed to heparin |c U. Hoffmann, G. Huhle, K. Haseroth, D.L. Heene, J. Harenberg |
| 264 | 1 | |c 01 September 1999 | |
| 300 | |a 3 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.05.2022 | ||
| 520 | |a The heparin-induced thrombocytopenia type II is a rare but important drug related complication associated with thrombocytopenia and thrombosis. We report on a patient with elective revision of the total hip arthroplasty. Preoperatively for nineteen days, the patient received unfractionated heparin 5000 IU three times daily for thromboprophylaxis. Postoperatively the patient developed a platelet drop from 236000/μl to 69000/μl an iliac vein thrombosis and pulmonary embolism. In assumption of heparin induced thrombocytopenia anticoagulation was switched to danaparoid-sodium subcutaneously. Platelet count rised to normal values while three days. Because of a negative heparin-induced platelet aggregation assay, anticoagulation was switched to a PTT controlled high dose intravenous unfractionated heparin. Two days after re-exposition to heparin platelet counts dropped to 34000/μl blood. The patient died 12 days after readministration of heparin due to respiratory and circulatory failure. Postmortem analysis of serum revealed positive heparin/platelet factor 4 IgG-antibodies. | ||
| 650 | 4 | |a Arthroplastie de hanche | |
| 650 | 4 | |a Heparin | |
| 650 | 4 | |a Hip-replacement | |
| 650 | 4 | |a Reexposition | |
| 650 | 4 | |a Réexposition | |
| 650 | 4 | |a Thrombocytopenia | |
| 650 | 4 | |a Thrombocytopénie | |
| 700 | 1 | |a Huhle, Günter |e VerfasserIn |0 (DE-588)1077938500 |0 (DE-627)837763940 |0 (DE-576)173334431 |4 aut | |
| 700 | 1 | |a Rossol-Haseroth, Karin |d 1972- |e VerfasserIn |0 (DE-588)12083166X |0 (DE-627)705021823 |0 (DE-576)292406797 |4 aut | |
| 700 | 1 | |a Heene, Dieter L. |d 1935- |e VerfasserIn |0 (DE-588)1103551418 |0 (DE-627)861344979 |0 (DE-576)470661275 |4 aut | |
| 700 | 1 | |a Harenberg, Job |d 1950- |e VerfasserIn |0 (DE-588)108825507 |0 (DE-627)655891498 |0 (DE-576)339563745 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of orthopaedic surgery & traumatology |d Paris : Springer France, 1991 |g 9(1999), 3, Seite 205-207 |h Online-Ressource |w (DE-627)271175354 |w (DE-600)1478935-8 |w (DE-576)113948107 |x 1432-1068 |7 nnas |a A fatal complication in a patient with heparin-induced thrombocytopenia type II re-exposed to heparin |
| 773 | 1 | 8 | |g volume:9 |g year:1999 |g number:3 |g pages:205-207 |g extent:3 |a A fatal complication in a patient with heparin-induced thrombocytopenia type II re-exposed to heparin |
| 856 | 4 | 0 | |u https://doi.org/10.1007/BF00542596 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220505 | ||
| 994 | |a 1999 | ||
| 998 | |g 108825507 |a Harenberg, Job |m 108825507:Harenberg, Job |d 60000 |d 61000 |d 60000 |e 60000PH108825507 |e 61000PH108825507 |e 60000PH108825507 |k 0/60000/ |k 1/60000/61000/ |k 0/60000/ |p 5 |y j | ||
| 998 | |g 1103551418 |a Heene, Dieter L. |m 1103551418:Heene, Dieter L. |d 60000 |d 61000 |d 60000 |e 60000PH1103551418 |e 61000PH1103551418 |e 60000PH1103551418 |k 0/60000/ |k 1/60000/61000/ |k 0/60000/ |p 4 | ||
| 998 | |g 12083166X |a Rossol-Haseroth, Karin |m 12083166X:Rossol-Haseroth, Karin |d 60000 |d 65400 |e 60000PR12083166X |e 65400PR12083166X |k 0/60000/ |k 1/60000/65400/ |p 3 | ||
| 998 | |g 1077938500 |a Huhle, Günter |m 1077938500:Huhle, Günter |d 60000 |d 61000 |e 60000PH1077938500 |e 61000PH1077938500 |k 0/60000/ |k 1/60000/61000/ |p 2 | ||
| 998 | |g 115587098 |a Hoffmann, Ursula |m 115587098:Hoffmann, Ursula |d 60000 |d 61000 |d 60000 |e 60000PH115587098 |e 61000PH115587098 |e 60000PH115587098 |k 0/60000/ |k 1/60000/61000/ |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1801016186 |e 4129430890 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"physDesc":[{"extent":"3 S."}],"recId":"1801016186","id":{"eki":["1801016186"],"doi":["10.1007/BF00542596"]},"origin":[{"dateIssuedDisp":"01 September 1999","dateIssuedKey":"1999"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 05.05.2022"],"relHost":[{"language":["eng","fre"],"recId":"271175354","part":{"text":"9(1999), 3, Seite 205-207","year":"1999","volume":"9","issue":"3","extent":"3","pages":"205-207"},"origin":[{"dateIssuedKey":"1991","dateIssuedDisp":"1991-","publisherPlace":"Paris","publisher":"Springer France"}],"note":["Gesehen am 05.12.05","Fortsetzung der Druck-Ausgabe"],"titleAlt":[{"title":"Orthopédie - traumatologie"}],"title":[{"title_sort":"European journal of orthopaedic surgery & traumatology","subtitle":"official organ of Société d'Orthopédie et de Traumatologie de l'Est de la France (S.O.T.EST), Groupe d'Etude pour la Chirurgie Osseuse (G.E.C.O.), European Bone and Joint Infection Society (E.B.J.I.S.) ... = Orthopedie traumatologie","title":"European journal of orthopaedic surgery & traumatology"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["271175354"],"zdb":["1478935-8"],"issn":["1432-1068"]},"pubHistory":["1.1991 -"],"type":{"media":"Online-Ressource","bibl":"periodical"},"titleTranslated":[{"translated":"Orthopedie traumatologie"}],"disp":"A fatal complication in a patient with heparin-induced thrombocytopenia type II re-exposed to heparinEuropean journal of orthopaedic surgery & traumatology"}],"name":{"displayForm":["U. Hoffmann, G. Huhle, K. Haseroth, D.L. Heene, J. Harenberg"]},"title":[{"title_sort":"fatal complication in a patient with heparin-induced thrombocytopenia type II re-exposed to heparin","title":"A fatal complication in a patient with heparin-induced thrombocytopenia type II re-exposed to heparin"}],"person":[{"given":"Ursula","display":"Hoffmann, Ursula","roleDisplay":"VerfasserIn","role":"aut","family":"Hoffmann"},{"role":"aut","roleDisplay":"VerfasserIn","family":"Huhle","given":"Günter","display":"Huhle, Günter"},{"given":"Karin","display":"Rossol-Haseroth, Karin","family":"Rossol-Haseroth","role":"aut","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","role":"aut","family":"Heene","display":"Heene, Dieter L.","given":"Dieter L."},{"roleDisplay":"VerfasserIn","role":"aut","family":"Harenberg","given":"Job","display":"Harenberg, Job"}]} | ||
| SRT | |a HOFFMANNURFATALCOMPL0119 | ||