A fatal complication in a patient with heparin-induced thrombocytopenia type II re-exposed to heparin
The heparin-induced thrombocytopenia type II is a rare but important drug related complication associated with thrombocytopenia and thrombosis. We report on a patient with elective revision of the total hip arthroplasty. Preoperatively for nineteen days, the patient received unfractionated heparin 5...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 September 1999
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| In: |
European journal of orthopaedic surgery & traumatology
Year: 1999, Volume: 9, Issue: 3, Pages: 205-207 |
| ISSN: | 1432-1068 |
| DOI: | 10.1007/BF00542596 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/BF00542596
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| Author Notes: | U. Hoffmann, G. Huhle, K. Haseroth, D.L. Heene, J. Harenberg |
| Summary: | The heparin-induced thrombocytopenia type II is a rare but important drug related complication associated with thrombocytopenia and thrombosis. We report on a patient with elective revision of the total hip arthroplasty. Preoperatively for nineteen days, the patient received unfractionated heparin 5000 IU three times daily for thromboprophylaxis. Postoperatively the patient developed a platelet drop from 236000/μl to 69000/μl an iliac vein thrombosis and pulmonary embolism. In assumption of heparin induced thrombocytopenia anticoagulation was switched to danaparoid-sodium subcutaneously. Platelet count rised to normal values while three days. Because of a negative heparin-induced platelet aggregation assay, anticoagulation was switched to a PTT controlled high dose intravenous unfractionated heparin. Two days after re-exposition to heparin platelet counts dropped to 34000/μl blood. The patient died 12 days after readministration of heparin due to respiratory and circulatory failure. Postmortem analysis of serum revealed positive heparin/platelet factor 4 IgG-antibodies. |
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| Item Description: | Gesehen am 05.05.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1432-1068 |
| DOI: | 10.1007/BF00542596 |