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Daily honey consumption does not change CYP3A activity in humans

Several studies investigating the interaction of honey and drug-metabolizing enzymes showed controversial results, with some suggesting that honey induces CYP3A-mediated metabolism in mammals and humans. This clinical trial was conducted to determine the effect of repeated honey administration on hu...

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Main Authors: Rudofsky, Leonie (Author) , Burhenne, Jürgen (Author) , Weiß, Johanna (Author) , Völker, Michael (Author) , Unger, Matthias (Author) , Mikus, Gerd (Author) , Haefeli, Walter E. (Author)
Format: Article (Journal)
Language:English
Published: 2011
In: Journal of clinical pharmacology
Year: 2011, Volume: 51, Issue: 8, Pages: 1223-1232
ISSN:1552-4604
DOI:10.1177/0091270010382022
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1177/0091270010382022
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1177/0091270010382022
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Author Notes:Leonie Fetzner, Jürgen Burhenne, PhD, Johanna Weiss, PhD, Michael Völker, Matthias Unger, PhD, Gerd Mikus, MD, and Walter Emil Haefeli, MD

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520 |a Several studies investigating the interaction of honey and drug-metabolizing enzymes showed controversial results, with some suggesting that honey induces CYP3A-mediated metabolism in mammals and humans. This clinical trial was conducted to determine the effect of repeated honey administration on human CYP3A enzyme activity using midazolam as a marker substance. In a randomized, single-blind, parallel-group study, 20 healthy volunteers were randomly assigned to receive either honey (2 × 20 g/d) or artificial honey (2 × 20 g/d) over a period of 10 days. To determine intestinal and hepatic CYP3A activity, oral (4 mg) and intravenous (2 mg) midazolam was administered in a semi-simultaneous way before honey administration, after the last honey administration, and 1 and 6 days thereafter. At baseline after oral midazolam, the partial metabolic clearance was similar in both groups (honey: 917.8 ± 234.6 mL/min vs artificial honey: 973.5 ± 373.8 mL/min). Ten days of honey administration did not change partial metabolic clearance (honey: 1016 ± 268 mL/min vs artificial honey: 1043 ± 450 mL/min), which was also true 1 and 6 days later. Neither honey nor artificial honey in amounts usually consumed affected the intestinal and hepatic CYP3A activity in healthy volunteers. 
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