The role of T lymphocytes in ANCA associated vasculitis: neglected or revisited?
"Antineutrophil cytoplasmic antibodies (ANCA) are pathogenic--Oh yes they are!" is the title of a recent review [Falk et al. 2002], discussing the current evidence on the pathogenic role of ANCA in vasculitis. But what about T lymphocytes? Do these cells also contribute to disease manifest...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2005
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| In: |
Clinical nephrology
Year: 2005, Jahrgang: 64, Heft: 6, Pages: 471-474 |
| DOI: | 10.5414/cnp64471 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.5414/cnp64471
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| Verfasserangaben: | A.I. Kälsch, F.J. van der Woude, B.A. Yard |
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| 245 | 1 | 4 | |a The role of T lymphocytes in ANCA associated vasculitis |b neglected or revisited? |c A.I. Kälsch, F.J. van der Woude, B.A. Yard |
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| 520 | |a "Antineutrophil cytoplasmic antibodies (ANCA) are pathogenic--Oh yes they are!" is the title of a recent review [Falk et al. 2002], discussing the current evidence on the pathogenic role of ANCA in vasculitis. But what about T lymphocytes? Do these cells also contribute to disease manifestation and if so to what extend? T-cells most likely play a role in delivering proper signals to autoreactive B cells for the production of ANCA, but, in the efferent arm of the immune response the involvement of T cells is less obvious and controversially discussed. Numerous studies provide evidence that peripheral T-cell phenotypes are dramatically changed in ANCA associated vasculitis (AAV) patients. How these changes relate to disease manifestation is still a matter of discussion. In an attempt to provide a better understanding of how T cells might play a role in AAV, the present paper will review recent data presented at the 12th international vasculitis and ANCA workshop. | ||
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