-137 (G/C) IL-18 promoter polymorphism in patients with inflammatory bowel disease
Objective. There is strong evidence that genetic factors contribute to the susceptibility for inflammatory bowel diseases (IBD). Recently, IL-18 promoter polymorphisms were characterized as risk factors for inflammatory diseases such as sepsis, asthma and adult-onset Still's disease. The aim of...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2005
|
| In: |
Scandinavian journal of gastroenterology
Year: 2005, Jahrgang: 40, Heft: 12, Pages: 1438-1443 |
| ISSN: | 1502-7708 |
| DOI: | 10.1080/00365520510023738 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/00365520510023738 Verlag, lizenzpflichtig, Volltext: https://www.tandfonline.com/doi/full/10.1080/00365520510023738 
|
| Verfasserangaben: | Stephan L. Haas, W Andreas Koch, Stefan Schreiber, Iris Reinhard, Noriko Koyama, Manfred V. Singer & Ulrich Böcker |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1801180431 | ||
| 003 | DE-627 | ||
| 005 | 20230427140252.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220509s2005 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/00365520510023738 |2 doi | |
| 035 | |a (DE-627)1801180431 | ||
| 035 | |a (DE-599)KXP1801180431 | ||
| 035 | |a (OCoLC)1341459742 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Haas, Stephan |d 1968- |e VerfasserIn |0 (DE-588)122762606 |0 (DE-627)706033132 |0 (DE-576)332722163 |4 aut | |
| 245 | 1 | 0 | |a -137 (G/C) IL-18 promoter polymorphism in patients with inflammatory bowel disease |c Stephan L. Haas, W Andreas Koch, Stefan Schreiber, Iris Reinhard, Noriko Koyama, Manfred V. Singer & Ulrich Böcker |
| 246 | 3 | 3 | |a Minus one hundred thirty-seven (G/C) IL-eighteen promoter polymorphism in patients with inflammatory bowel disease |
| 264 | 1 | |c 2005 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online: 08 Jul 2009 | ||
| 500 | |a Gesehen am 09.05.2022 | ||
| 520 | |a Objective. There is strong evidence that genetic factors contribute to the susceptibility for inflammatory bowel diseases (IBD). Recently, IL-18 promoter polymorphisms were characterized as risk factors for inflammatory diseases such as sepsis, asthma and adult-onset Still's disease. The aim of this study was to determine whether the −137 (G/C) IL-18 promoter polymorphism was associated with IBD susceptibility. Material and methods. For association analysis, 470 patients with Crohn's disease (CD), 235 unrelated patients with ulcerative colitis (UC) and 347 controls were enrolled. Furthermore, 233 UC and 470 CD trios were included for segregation analysis. Genotyping was performed by application of the TaqMan MGB biallelic discrimination system. Results. When comparing genotype frequencies of CD and UC patients versus controls, no significant difference was found (p=0.089 and p=0.078, respectively). However, the Cochran-Armitage trend test revealed a rising probability for CD and UC with increasing number of G alleles (p=0.030 and 0.028, respectively) for the case-control analysis. On the contrary, the family-based transmission disequilibrium test (TDT) did not show an association of the G allele with CD or UC in 470 CD and 233 UC trios (p=0.53 and p=0.79, respectively). Conclusion. The −137 (G/C) IL-18 promoter polymorphism is not a susceptibility factor for IBD in a German cohort. | ||
| 650 | 4 | |a Crohn's disease | |
| 650 | 4 | |a inflammatory bowel disease | |
| 650 | 4 | |a interleukin-18 | |
| 650 | 4 | |a polymorphism | |
| 650 | 4 | |a ulcerative colitis | |
| 700 | 1 | |a Andreas Koch, W |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schreiber, Stefan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Reinhard, Iris |e VerfasserIn |4 aut | |
| 700 | 1 | |a Koyama, Noriko |e VerfasserIn |4 aut | |
| 700 | 1 | |a Singer, Manfred V. |d 1945- |e VerfasserIn |0 (DE-588)121081958 |0 (DE-627)081074069 |0 (DE-576)169905330 |4 aut | |
| 700 | 1 | |a Böcker, Ulrich |d 1965- |e VerfasserIn |0 (DE-588)1059893029 |0 (DE-627)798968990 |0 (DE-576)416025889 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Scandinavian journal of gastroenterology |d Abingdon : Taylor & Francis Group, 1966 |g 40(2005), 12, Seite 1438-1443 |h Online-Ressource |w (DE-627)302725571 |w (DE-600)1492631-3 |w (DE-576)088704866 |x 1502-7708 |7 nnas |a -137 (G/C) IL-18 promoter polymorphism in patients with inflammatory bowel disease |
| 773 | 1 | 8 | |g volume:40 |g year:2005 |g number:12 |g pages:1438-1443 |g extent:6 |a -137 (G/C) IL-18 promoter polymorphism in patients with inflammatory bowel disease |
| 856 | 4 | 0 | |u https://doi.org/10.1080/00365520510023738 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.tandfonline.com/doi/full/10.1080/00365520510023738 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220509 | ||
| 993 | |a Article | ||
| 994 | |a 2005 | ||
| 998 | |g 1059893029 |a Böcker, Ulrich |m 1059893029:Böcker, Ulrich |d 60000 |d 61100 |e 60000PB1059893029 |e 61100PB1059893029 |k 0/60000/ |k 1/60000/61100/ |p 7 |y j | ||
| 998 | |g 121081958 |a Singer, Manfred V. |m 121081958:Singer, Manfred V. |d 60000 |d 61100 |e 60000PS121081958 |e 61100PS121081958 |k 0/60000/ |k 1/60000/61100/ |p 6 | ||
| 998 | |g 122762606 |a Haas, Stephan |m 122762606:Haas, Stephan |d 60000 |d 61100 |e 60000PH122762606 |e 61100PH122762606 |k 0/60000/ |k 1/60000/61100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1801180431 |e 4130265733 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"-137 (G/C) IL-18 promoter polymorphism in patients with inflammatory bowel disease","title":"-137 (G/C) IL-18 promoter polymorphism in patients with inflammatory bowel disease"}],"relHost":[{"note":["Gesehen am 31.08.15"],"part":{"text":"40(2005), 12, Seite 1438-1443","pages":"1438-1443","extent":"6","year":"2005","volume":"40","issue":"12"},"recId":"302725571","type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.1966 -"],"id":{"eki":["302725571"],"zdb":["1492631-3"],"issn":["1502-7708"]},"title":[{"title":"Scandinavian journal of gastroenterology","title_sort":"Scandinavian journal of gastroenterology"}],"language":["eng"],"disp":"-137 (G/C) IL-18 promoter polymorphism in patients with inflammatory bowel diseaseScandinavian journal of gastroenterology","origin":[{"publisher":"Taylor & Francis Group ; Scandinavian Univ. Press ; Taylor & Francis ; Informa Healthcare","dateIssuedDisp":"1966-","publisherPlace":"Abingdon ; Oslo [u.a.] ; London [u.a.] ; London","dateIssuedKey":"1966"}],"physDesc":[{"extent":"Online-Ressource"}]}],"origin":[{"dateIssuedDisp":"2005","dateIssuedKey":"2005"}],"name":{"displayForm":["Stephan L. Haas, W Andreas Koch, Stefan Schreiber, Iris Reinhard, Noriko Koyama, Manfred V. Singer & Ulrich Böcker"]},"id":{"doi":["10.1080/00365520510023738"],"eki":["1801180431"]},"physDesc":[{"extent":"6 S."}],"titleAlt":[{"title":"Minus one hundred thirty-seven (G/C) IL-eighteen promoter polymorphism in patients with inflammatory bowel disease"}],"language":["eng"],"person":[{"roleDisplay":"VerfasserIn","role":"aut","given":"Stephan","display":"Haas, Stephan","family":"Haas"},{"given":"W","role":"aut","roleDisplay":"VerfasserIn","display":"Andreas Koch, W","family":"Andreas Koch"},{"given":"Stefan","roleDisplay":"VerfasserIn","role":"aut","display":"Schreiber, Stefan","family":"Schreiber"},{"given":"Iris","role":"aut","roleDisplay":"VerfasserIn","display":"Reinhard, Iris","family":"Reinhard"},{"family":"Koyama","roleDisplay":"VerfasserIn","role":"aut","given":"Noriko","display":"Koyama, Noriko"},{"family":"Singer","given":"Manfred V.","role":"aut","roleDisplay":"VerfasserIn","display":"Singer, Manfred V."},{"display":"Böcker, Ulrich","role":"aut","roleDisplay":"VerfasserIn","given":"Ulrich","family":"Böcker"}],"recId":"1801180431","note":["Published online: 08 Jul 2009","Gesehen am 09.05.2022"],"type":{"media":"Online-Ressource","bibl":"article-journal"}} | ||
| SRT | |a HAASSTEPHA137GCIL18P2005 | ||