Current molecular diagnostic approaches to systemic infections with Aspergillus species in patients with Hematological Malignancies

Within the recent years, novel molecular methods, especially PCR assays, have been developed to improve the diagnosis of invasive aspergillosis in patients with malignant hematological diseases being at high risk for this life-threatening infection. Early diagnosis and treatment are essential for ad...

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Hauptverfasser: Buchheidt, Dieter (VerfasserIn) , Hummel, Margit (VerfasserIn) , Schleiermacher, Dietlind (VerfasserIn) , Spiess, Birgit (VerfasserIn) , Hehlmann, Rüdiger (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2004
In: Leukemia and lymphoma
Year: 2004, Jahrgang: 45, Heft: 3, Pages: 463-468
ISSN:1029-2403
DOI:10.1080/10428190310001593210
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/10428190310001593210
Volltext
Verfasserangaben:Dieter Buchheidt, Margit Hummel, Dietlind Schleiermacher, Birgit Spiess, Rüdiger Hehlmann
Beschreibung
Zusammenfassung:Within the recent years, novel molecular methods, especially PCR assays, have been developed to improve the diagnosis of invasive aspergillosis in patients with malignant hematological diseases being at high risk for this life-threatening infection. Early diagnosis and treatment are essential for adequate therapeutical management, which however, often remains difficult since most of the diagnostic tools used clinically at present either lack specificity or acceptable sensitivity. The clinical value, advantages and remaining problems of recently developed molecular approaches to detect the emerging fungal pathogen are reviewed.
Beschreibung:Elektronische Reproduktion der Druckausgabe
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Beschreibung:Online Resource
ISSN:1029-2403
DOI:10.1080/10428190310001593210