Identification of specific coronary artery disease phenotypes implicating differential pathophysiologies
The roles of multiple risk factors of coronary artery disease (CAD) are well established. Commonly, CAD is considered as a single disease entity. We wish to examine whether coronary angiography allows to identify distinct CAD phenotypes associated with major risk factors and differences in prognosis...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
10 March 2022
|
| In: |
Frontiers in Cardiovascular Medicine
Year: 2022, Volume: 9, Pages: 1-10 |
| ISSN: | 2297-055X |
| DOI: | 10.3389/fcvm.2022.778206 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fcvm.2022.778206 Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/article/10.3389/fcvm.2022.778206 
|
| Author Notes: | Jona B. Krohn, Y Nhi Nguyen, Mohammadreza Akhavanpoor, Christian Erbel, Gabriele Domschke, Fabian Linden, Marcus E. Kleber, Graciela Delgado, Winfried März, Hugo A. Katus and Christian A. Gleissner |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1801840342 | ||
| 003 | DE-627 | ||
| 005 | 20230426073535.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220516s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fcvm.2022.778206 |2 doi | |
| 035 | |a (DE-627)1801840342 | ||
| 035 | |a (DE-599)KXP1801840342 | ||
| 035 | |a (OCoLC)1341459667 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Krohn, Jona B. |d 1988- |e VerfasserIn |0 (DE-588)113752880X |0 (DE-627)894765272 |0 (DE-576)491446411 |4 aut | |
| 245 | 1 | 0 | |a Identification of specific coronary artery disease phenotypes implicating differential pathophysiologies |c Jona B. Krohn, Y Nhi Nguyen, Mohammadreza Akhavanpoor, Christian Erbel, Gabriele Domschke, Fabian Linden, Marcus E. Kleber, Graciela Delgado, Winfried März, Hugo A. Katus and Christian A. Gleissner |
| 264 | 1 | |c 10 March 2022 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.05.2022 | ||
| 520 | |a The roles of multiple risk factors of coronary artery disease (CAD) are well established. Commonly, CAD is considered as a single disease entity. We wish to examine whether coronary angiography allows to identify distinct CAD phenotypes associated with major risk factors and differences in prognosis.MethodsIn a cohort of 4,344 patients undergoing coronary angiography at Heidelberg University Hospital between 2014 and 2016, cluster analysis of angiographic reports identified subgroups with similar patterns of spatial distribution of high-grade stenoses. Clusters were independently confirmed in 3,129 patients from the LURIC study.ResultsFour clusters were identified: cluster one lacking critical stenoses comprised the highest percentage of women with the lowest cardiovascular risk. Patients in cluster two exhibiting high-grade stenosis of the proximal RCA had a high prevalence of the metabolic syndrome, and showed the highest levels of inflammatory biomarkers. Cluster three with predominant proximal LAD stenosis frequently presented with acute coronary syndrome and elevated troponin levels. Cluster four with high-grade stenoses throughout had the oldest patients with the highest overall cardiovascular risk. All-cause and cardiovascular mortality differed significantly between the clusters.ConclusionsWe identified four phenotypic subgroups of CAD bearing distinct demographic and biochemical characteristics with differences in prognosis, which may indicate multiple disease entities currently summarized as CAD. | ||
| 700 | 1 | |a Nguyen, Y Nhi |d 1993- |e VerfasserIn |0 (DE-588)1188594672 |0 (DE-627)1667547879 |4 aut | |
| 700 | 1 | |a Akhavanpoor, Mohammadreza |d 1982- |e VerfasserIn |0 (DE-588)1022954121 |0 (DE-627)717338517 |0 (DE-576)366213652 |4 aut | |
| 700 | 1 | |a Erbel, Christian |d 1976- |e VerfasserIn |0 (DE-588)132600927 |0 (DE-627)524413401 |0 (DE-576)299249603 |4 aut | |
| 700 | 1 | |a Domschke, Gabriele |d 1989- |e VerfasserIn |0 (DE-588)1074372379 |0 (DE-627)832072249 |0 (DE-576)442619839 |4 aut | |
| 700 | 1 | |a Linden, Fabian |d 1988- |e VerfasserIn |0 (DE-588)1074372239 |0 (DE-627)832071978 |0 (DE-576)442619367 |4 aut | |
| 700 | 1 | |a Kleber, Marcus E. |d 1974- |e VerfasserIn |0 (DE-588)1030135177 |0 (DE-627)734830440 |0 (DE-576)377941379 |4 aut | |
| 700 | 1 | |a Delgado Gonzales de Kleber, Graciela |d 1960- |e VerfasserIn |0 (DE-588)1070236403 |0 (DE-627)823400379 |0 (DE-576)429882386 |4 aut | |
| 700 | 1 | |a März, Winfried |d 1958- |e VerfasserIn |0 (DE-588)1027603599 |0 (DE-627)729463605 |0 (DE-576)373454635 |4 aut | |
| 700 | 1 | |a Katus, Hugo |d 1951- |e VerfasserIn |0 (DE-588)108916618 |0 (DE-627)577155040 |0 (DE-576)289625076 |4 aut | |
| 700 | 1 | |a Gleißner, Christian A. |d 1976- |e VerfasserIn |0 (DE-588)124269907 |0 (DE-627)085750522 |0 (DE-576)294095578 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in Cardiovascular Medicine |d Lausanne : Frontiers Media, 2014 |g 9(2022), Artikel-ID 778206, Seite 1-10 |h Online-Ressource |w (DE-627)793951607 |w (DE-600)2781496-8 |w (DE-576)412047004 |x 2297-055X |7 nnas |a Identification of specific coronary artery disease phenotypes implicating differential pathophysiologies |
| 773 | 1 | 8 | |g volume:9 |g year:2022 |g elocationid:778206 |g pages:1-10 |g extent:10 |a Identification of specific coronary artery disease phenotypes implicating differential pathophysiologies |
| 856 | 4 | 0 | |u https://doi.org/10.3389/fcvm.2022.778206 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.frontiersin.org/article/10.3389/fcvm.2022.778206 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220516 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 124269907 |a Gleißner, Christian A. |m 124269907:Gleißner, Christian A. |d 50000 |e 50000PG124269907 |k 0/50000/ |p 11 |y j | ||
| 998 | |g 108916618 |a Katus, Hugo |m 108916618:Katus, Hugo |d 910000 |d 910100 |d 50000 |e 910000PK108916618 |e 910100PK108916618 |e 50000PK108916618 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 10 | ||
| 998 | |g 1027603599 |a März, Winfried |m 1027603599:März, Winfried |d 60000 |d 61400 |e 60000PM1027603599 |e 61400PM1027603599 |k 0/60000/ |k 1/60000/61400/ |p 9 | ||
| 998 | |g 1070236403 |a Delgado Gonzales de Kleber, Graciela |m 1070236403:Delgado Gonzales de Kleber, Graciela |d 60000 |d 61400 |e 60000PD1070236403 |e 61400PD1070236403 |k 0/60000/ |k 1/60000/61400/ |p 8 | ||
| 998 | |g 1030135177 |a Kleber, Marcus E. |m 1030135177:Kleber, Marcus E. |d 60000 |d 61400 |e 60000PK1030135177 |e 61400PK1030135177 |k 0/60000/ |k 1/60000/61400/ |p 7 | ||
| 998 | |g 1074372239 |a Linden, Fabian |m 1074372239:Linden, Fabian |d 910000 |d 910100 |e 910000PL1074372239 |e 910100PL1074372239 |k 0/910000/ |k 1/910000/910100/ |p 6 | ||
| 998 | |g 1074372379 |a Domschke, Gabriele |m 1074372379:Domschke, Gabriele |d 910000 |d 910100 |e 910000PD1074372379 |e 910100PD1074372379 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 132600927 |a Erbel, Christian |m 132600927:Erbel, Christian |d 910000 |d 910100 |d 50000 |e 910000PE132600927 |e 910100PE132600927 |e 50000PE132600927 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 4 | ||
| 998 | |g 1022954121 |a Akhavanpoor, Mohammadreza |m 1022954121:Akhavanpoor, Mohammadreza |d 50000 |e 50000PA1022954121 |k 0/50000/ |p 3 | ||
| 998 | |g 113752880X |a Krohn, Jona B. |m 113752880X:Krohn, Jona B. |d 910000 |d 910100 |e 910000PK113752880X |e 910100PK113752880X |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1801840342 |e 4134433592 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 25.05.2022"],"language":["eng"],"recId":"1801840342","origin":[{"dateIssuedDisp":"10 March 2022","dateIssuedKey":"2022"}],"name":{"displayForm":["Jona B. Krohn, Y Nhi Nguyen, Mohammadreza Akhavanpoor, Christian Erbel, Gabriele Domschke, Fabian Linden, Marcus E. Kleber, Graciela Delgado, Winfried März, Hugo A. Katus and Christian A. Gleissner"]},"id":{"doi":["10.3389/fcvm.2022.778206"],"eki":["1801840342"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"relHost":[{"language":["eng"],"recId":"793951607","note":["Gesehen am 04.06.20"],"origin":[{"dateIssuedKey":"2014","dateIssuedDisp":"2014-","publisher":"Frontiers Media","publisherPlace":"Lausanne"}],"pubHistory":["2014 -"],"titleAlt":[{"title":"FCVM"},{"title":"Front. Cardiovasc. Med"}],"disp":"Identification of specific coronary artery disease phenotypes implicating differential pathophysiologiesFrontiers in Cardiovascular Medicine","part":{"extent":"10","pages":"1-10","volume":"9","text":"9(2022), Artikel-ID 778206, Seite 1-10","year":"2022"},"id":{"issn":["2297-055X"],"eki":["793951607"],"zdb":["2781496-8"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Frontiers in Cardiovascular Medicine","title_sort":"Frontiers in Cardiovascular Medicine"}]}],"physDesc":[{"extent":"10 S."}],"title":[{"title":"Identification of specific coronary artery disease phenotypes implicating differential pathophysiologies","title_sort":"Identification of specific coronary artery disease phenotypes implicating differential pathophysiologies"}],"person":[{"given":"Jona B.","role":"aut","display":"Krohn, Jona B.","family":"Krohn"},{"given":"Y Nhi","role":"aut","display":"Nguyen, Y Nhi","family":"Nguyen"},{"display":"Akhavanpoor, Mohammadreza","family":"Akhavanpoor","given":"Mohammadreza","role":"aut"},{"given":"Christian","role":"aut","display":"Erbel, Christian","family":"Erbel"},{"display":"Domschke, Gabriele","family":"Domschke","given":"Gabriele","role":"aut"},{"family":"Linden","display":"Linden, Fabian","role":"aut","given":"Fabian"},{"given":"Marcus E.","role":"aut","display":"Kleber, Marcus E.","family":"Kleber"},{"given":"Graciela","role":"aut","display":"Delgado Gonzales de Kleber, Graciela","family":"Delgado Gonzales de Kleber"},{"family":"März","display":"März, Winfried","role":"aut","given":"Winfried"},{"role":"aut","given":"Hugo","family":"Katus","display":"Katus, Hugo"},{"display":"Gleißner, Christian A.","family":"Gleißner","given":"Christian A.","role":"aut"}]} | ||
| SRT | |a KROHNJONABIDENTIFICA1020 | ||