Neutralizing antibody activity against the B.1.617.2 (delta) variant before and after a third BNT162b2 vaccine dose in hemodialysis patients
Hemodialysis patients are at high risk for severe COVID-19, and impaired seroconversion rates have been demonstrated after COVID-19 vaccination. Humoral immunity wanes over time and variants of concern with immune escape are posing an increasing threat. Little is known about protection against the B...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
04 March 2022
|
| In: |
Frontiers in immunology
Year: 2022, Jahrgang: 13, Pages: 1-17 |
| ISSN: | 1664-3224 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/article/10.3389/fimmu.2022.840136
|
| Verfasserangaben: | Louise Benning, Katrin Klein, Christian Morath, Marie Bartenschlager, Heeyoung Kim, Mirabel Buylaert, Marvin Reineke, Maximilian Töllner, Christian Nusshag, Florian Kälble, Paula Reichel, Paul Schnitzler, Martin Zeier, Caner Süsal, Ralf Bartenschlager, Matthias Schaier and Claudius Speer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1802110887 | ||
| 003 | DE-627 | ||
| 005 | 20220820183643.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220517s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fimmu.2022.840136 |2 doi | |
| 035 | |a (DE-627)1802110887 | ||
| 035 | |a (DE-599)KXP1802110887 | ||
| 035 | |a (OCoLC)1341459819 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Benning, Louise |d 1993- |e VerfasserIn |0 (DE-588)1207775207 |0 (DE-627)1694098966 |4 aut | |
| 245 | 1 | 0 | |a Neutralizing antibody activity against the B.1.617.2 (delta) variant before and after a third BNT162b2 vaccine dose in hemodialysis patients |c Louise Benning, Katrin Klein, Christian Morath, Marie Bartenschlager, Heeyoung Kim, Mirabel Buylaert, Marvin Reineke, Maximilian Töllner, Christian Nusshag, Florian Kälble, Paula Reichel, Paul Schnitzler, Martin Zeier, Caner Süsal, Ralf Bartenschlager, Matthias Schaier and Claudius Speer |
| 264 | 1 | |c 04 March 2022 | |
| 300 | |a 17 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.05.2022 | ||
| 520 | |a Hemodialysis patients are at high risk for severe COVID-19, and impaired seroconversion rates have been demonstrated after COVID-19 vaccination. Humoral immunity wanes over time and variants of concern with immune escape are posing an increasing threat. Little is known about protection against the B.1.617.2 (delta) variant of concern in hemodialysis patients before and after third vaccination. We determined anti-S1 IgG, surrogate neutralizing, and IgG antibodies against different SARS-CoV-2 epitopes in 84 hemodialysis patients directly before and three weeks after a third vaccine dose with BNT162b2. Third vaccination was performed after a median (IQR) of 119 (109-165) days after second vaccination. In addition, neutralizing activity against the B.1.617.2 (delta) variant was assessed in 31 seroconverted hemodialysis patients before and after third vaccination. Triple seropositivity for anti-S1 IgG, surrogate neutralizing, and anti-RBD antibodies increased from 31/84 (37%) dialysis patients after second to 80/84 (95%) after third vaccination. Neutralizing activity against the B.1.617.2 (delta) variant was significantly higher after third vaccination with a median (IQR) ID50 of 1:320 (1:160-1:1280) compared with 1:20 (0-1:40) before a third vaccine dose (P<0.001). The anti-S1 IgG index showed the strongest correlation with the ID50 against the B.1.617.2 (delta) variant determined by live virus neutralization (r=0.91). We demonstrate low neutralizing activity against the B.1.617.2 (delta) variant in dialysis patients four months after standard two-dose vaccination but a substantial increase after a third vaccine dose. Booster vaccination(s) should be considered earlier than 6 months after the second vaccine dose in immunocompromised individuals. | ||
| 700 | 1 | |a Klein, Katrin |e VerfasserIn |0 (DE-588)1026480248 |0 (DE-627)726772305 |0 (DE-576)371826268 |4 aut | |
| 700 | 1 | |a Morath, Christian |d 1973- |e VerfasserIn |0 (DE-588)124036155 |0 (DE-627)085595837 |0 (DE-576)293989923 |4 aut | |
| 700 | 1 | |a Bartenschlager, Marie |e VerfasserIn |0 (DE-588)1073720594 |0 (DE-627)829365206 |0 (DE-576)435288385 |4 aut | |
| 700 | 1 | |a Kim, Heeyoung |e VerfasserIn |0 (DE-588)1233743139 |0 (DE-627)1758143819 |4 aut | |
| 700 | 1 | |a Buylaert, Mirabel |e VerfasserIn |0 (DE-588)1239862156 |0 (DE-627)1767941455 |4 aut | |
| 700 | 1 | |a Reineke, Marvin |e VerfasserIn |0 (DE-588)1257840568 |0 (DE-627)1802527826 |4 aut | |
| 700 | 1 | |a Töllner, Maximilian |d 1998- |e VerfasserIn |0 (DE-588)123547853X |0 (DE-627)1760481610 |4 aut | |
| 700 | 1 | |a Nußhag, Christian |d 1985- |e VerfasserIn |0 (DE-588)1054789827 |0 (DE-627)792121376 |0 (DE-576)410521280 |4 aut | |
| 700 | 1 | |a Kälble, Florian |d 1988- |e VerfasserIn |0 (DE-588)1046752294 |0 (DE-627)777026864 |0 (DE-576)400099039 |4 aut | |
| 700 | 1 | |a Reichel, Paula |e VerfasserIn |0 (DE-588)1243442522 |0 (DE-627)1774334631 |4 aut | |
| 700 | 1 | |a Schnitzler, Paul |d 1959- |e VerfasserIn |0 (DE-588)1022905643 |0 (DE-627)717329798 |0 (DE-576)366155695 |4 aut | |
| 700 | 1 | |a Zeier, Martin |e VerfasserIn |0 (DE-588)1026480302 |0 (DE-627)726772356 |0 (DE-576)371826438 |4 aut | |
| 700 | 1 | |a Süsal, Caner |e VerfasserIn |0 (DE-588)102648037X |0 (DE-627)726772763 |0 (DE-576)37182673X |4 aut | |
| 700 | 1 | |a Bartenschlager, Ralf |d 1958- |e VerfasserIn |0 (DE-588)1058097989 |0 (DE-627)796390509 |0 (DE-576)168706067 |4 aut | |
| 700 | 1 | |a Schaier, Matthias |d 1975- |e VerfasserIn |0 (DE-588)129029009 |0 (DE-627)387780335 |0 (DE-576)297455788 |4 aut | |
| 700 | 1 | |a Speer, Claudius |d 1990- |e VerfasserIn |0 (DE-588)1136602860 |0 (DE-627)893257893 |0 (DE-576)490687946 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in immunology |d Lausanne : Frontiers Media, 2010 |g 13(2022), Artikel-ID 840136, Seite 1-17 |h Online-Ressource |w (DE-627)657998354 |w (DE-600)2606827-8 |w (DE-576)343624834 |x 1664-3224 |7 nnas |a Neutralizing antibody activity against the B.1.617.2 (delta) variant before and after a third BNT162b2 vaccine dose in hemodialysis patients |
| 773 | 1 | 8 | |g volume:13 |g year:2022 |g elocationid:840136 |g pages:1-17 |g extent:17 |a Neutralizing antibody activity against the B.1.617.2 (delta) variant before and after a third BNT162b2 vaccine dose in hemodialysis patients |
| 856 | 4 | 0 | |u https://www.frontiersin.org/article/10.3389/fimmu.2022.840136 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220517 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1136602860 |a Speer, Claudius |m 1136602860:Speer, Claudius |d 910000 |d 910100 |e 910000PS1136602860 |e 910100PS1136602860 |k 0/910000/ |k 1/910000/910100/ |p 17 |y j | ||
| 998 | |g 129029009 |a Schaier, Matthias |m 129029009:Schaier, Matthias |d 50000 |e 50000PS129029009 |k 0/50000/ |p 16 | ||
| 998 | |g 1058097989 |a Bartenschlager, Ralf |m 1058097989:Bartenschlager, Ralf |d 910000 |d 911700 |e 910000PB1058097989 |e 911700PB1058097989 |k 0/910000/ |k 1/910000/911700/ |p 15 | ||
| 998 | |g 102648037X |a Süsal, Caner |m 102648037X:Süsal, Caner |d 50000 |e 50000PS102648037X |k 0/50000/ |p 14 | ||
| 998 | |g 1026480302 |a Zeier, Martin |m 1026480302:Zeier, Martin |d 910000 |d 910100 |d 50000 |e 910000PZ1026480302 |e 910100PZ1026480302 |e 50000PZ1026480302 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 13 | ||
| 998 | |g 1022905643 |a Schnitzler, Paul |m 1022905643:Schnitzler, Paul |d 910000 |d 911700 |d 50000 |e 910000PS1022905643 |e 911700PS1022905643 |e 50000PS1022905643 |k 0/910000/ |k 1/910000/911700/ |k 0/50000/ |p 12 | ||
| 998 | |g 1046752294 |a Kälble, Florian |m 1046752294:Kälble, Florian |d 910000 |d 910100 |e 910000PK1046752294 |e 910100PK1046752294 |k 0/910000/ |k 1/910000/910100/ |p 10 | ||
| 998 | |g 1054789827 |a Nußhag, Christian |m 1054789827:Nußhag, Christian |d 50000 |e 50000PN1054789827 |k 0/50000/ |p 9 | ||
| 998 | |g 123547853X |a Töllner, Maximilian |m 123547853X:Töllner, Maximilian |d 50000 |e 50000PT123547853X |k 0/50000/ |p 8 | ||
| 998 | |g 1257840568 |a Reineke, Marvin |m 1257840568:Reineke, Marvin |d 50000 |e 50000PR1257840568 |k 0/50000/ |p 7 | ||
| 998 | |g 1239862156 |a Buylaert, Mirabel |m 1239862156:Buylaert, Mirabel |d 50000 |e 50000PB1239862156 |k 0/50000/ |p 6 | ||
| 998 | |g 1233743139 |a Kim, Heeyoung |m 1233743139:Kim, Heeyoung |d 910000 |d 911700 |e 910000PK1233743139 |e 911700PK1233743139 |k 0/910000/ |k 1/910000/911700/ |p 5 | ||
| 998 | |g 1073720594 |a Bartenschlager, Marie |m 1073720594:Bartenschlager, Marie |p 4 | ||
| 998 | |g 124036155 |a Morath, Christian |m 124036155:Morath, Christian |d 910000 |d 910100 |e 910000PM124036155 |e 910100PM124036155 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 1026480248 |a Klein, Katrin |m 1026480248:Klein, Katrin |d 50000 |e 50000PK1026480248 |k 0/50000/ |p 2 | ||
| 998 | |g 1207775207 |a Benning, Louise |m 1207775207:Benning, Louise |d 50000 |e 50000PB1207775207 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1802110887 |e 413501643X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"language":["eng"],"part":{"volume":"13","year":"2022","text":"13(2022), Artikel-ID 840136, Seite 1-17","pages":"1-17","extent":"17"},"note":["Gesehen am 07.11.13"],"pubHistory":["1.2010 -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Neutralizing antibody activity against the B.1.617.2 (delta) variant before and after a third BNT162b2 vaccine dose in hemodialysis patientsFrontiers in immunology","recId":"657998354","title":[{"title_sort":"Frontiers in immunology","title":"Frontiers in immunology"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["657998354"],"issn":["1664-3224"],"zdb":["2606827-8"]},"origin":[{"dateIssuedKey":"2010","publisherPlace":"Lausanne","publisher":"Frontiers Media","dateIssuedDisp":"2010-"}]}],"origin":[{"dateIssuedDisp":"04 March 2022","dateIssuedKey":"2022"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Neutralizing antibody activity against the B.1.617.2 (delta) variant before and after a third BNT162b2 vaccine dose in hemodialysis patients","title":"Neutralizing antibody activity against the B.1.617.2 (delta) variant before and after a third BNT162b2 vaccine dose in hemodialysis patients"}],"id":{"doi":["10.3389/fimmu.2022.840136"],"eki":["1802110887"]},"physDesc":[{"extent":"17 S."}],"person":[{"given":"Louise","display":"Benning, Louise","role":"aut","family":"Benning"},{"display":"Klein, Katrin","given":"Katrin","family":"Klein","role":"aut"},{"given":"Christian","display":"Morath, Christian","family":"Morath","role":"aut"},{"family":"Bartenschlager","role":"aut","given":"Marie","display":"Bartenschlager, Marie"},{"given":"Heeyoung","display":"Kim, Heeyoung","role":"aut","family":"Kim"},{"family":"Buylaert","role":"aut","given":"Mirabel","display":"Buylaert, Mirabel"},{"given":"Marvin","display":"Reineke, Marvin","family":"Reineke","role":"aut"},{"role":"aut","family":"Töllner","display":"Töllner, Maximilian","given":"Maximilian"},{"given":"Christian","display":"Nußhag, Christian","family":"Nußhag","role":"aut"},{"display":"Kälble, Florian","given":"Florian","role":"aut","family":"Kälble"},{"family":"Reichel","role":"aut","given":"Paula","display":"Reichel, Paula"},{"family":"Schnitzler","role":"aut","given":"Paul","display":"Schnitzler, Paul"},{"given":"Martin","display":"Zeier, Martin","role":"aut","family":"Zeier"},{"display":"Süsal, Caner","given":"Caner","family":"Süsal","role":"aut"},{"display":"Bartenschlager, Ralf","given":"Ralf","role":"aut","family":"Bartenschlager"},{"given":"Matthias","display":"Schaier, Matthias","role":"aut","family":"Schaier"},{"display":"Speer, Claudius","given":"Claudius","role":"aut","family":"Speer"}],"recId":"1802110887","note":["Gesehen am 25.05.2022"],"language":["eng"],"name":{"displayForm":["Louise Benning, Katrin Klein, Christian Morath, Marie Bartenschlager, Heeyoung Kim, Mirabel Buylaert, Marvin Reineke, Maximilian Töllner, Christian Nusshag, Florian Kälble, Paula Reichel, Paul Schnitzler, Martin Zeier, Caner Süsal, Ralf Bartenschlager, Matthias Schaier and Claudius Speer"]}} | ||
| SRT | |a BENNINGLOUNEUTRALIZI0420 | ||