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Pak2 regulation of Nrf2 serves as a novel signaling nexus linking ER stress response and oxidative stress in the heart

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Endoplasmic Reticulum (ER) stress and oxidative stress have been highly implicated in the pathogenesis of cardiac hypertrophy and heart failure (HF). However, the mechanisms involved in the interplay between these processes in the heart are not fully understood. The present study sought to determine...

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Main Authors: Binder, Pablo (Author) , Nguyen, Binh (Author) , Collins, Lucy (Author) , Zi, Min (Author) , Liu, Wei (Author) , Christou, Foteini (Author) , Luo, Xiaojing (Author) , Hille, Susanne S. (Author) , Frey, Norbert (Author) , Cartwright, Elizabeth J. (Author) , Chernoff, Jonathan (Author) , Müller, Oliver J. (Author) , Guan, Kaomei (Author) , Wang, Xin (Author)
Format: Article (Journal)
Language:English
Published: 08 March 2022
In: Frontiers in Cardiovascular Medicine
Year: 2022, Volume: 9, Pages: 1-16
ISSN:2297-055X
Online Access:Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/article/10.3389/fcvm.2022.851419
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Author Notes:Pablo Binder, Binh Nguyen, Lucy Collins, Min Zi, Wei Liu, Foteini Christou, Xiaojing Luo, Susanne S. Hille, Norbert Frey, Elizabeth J. Cartwright, Jonathan Chernoff, Oliver J. Müller, Kaomei Guan and Xin Wang
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Electrophysiological effects of the sodium-glucose co-transporter-2 (SGLT2) inhibitor Dapagliflozin on human cardiac potassium channels by Müller, Mara Elena (Author) , Petersenn, Finn (Author) , Hackbarth, Juline (Author) , Pfeiffer, Julia (Author) , Gampp, Heike (Author) , Frey, Norbert (Author) , Lugenbiel, Patrick (Author) , Thomas, Dierk (Author) , Rahm, Ann-Kathrin (Author) ,


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CNP promotes antiarrhythmic effects via phosphodiesterase 2 by Cachorro, Eleder (Author) , Günscht, Mario (Author) , Schubert, Mario (Author) , Sadek, Mirna S. (Author) , Siegert, Johanna (Author) , Dutt, Fabian (Author) , Bauermeister, Carla (Author) , Quickert, Susann (Author) , Berning, Henrik (Author) , Nowakowski, Felix (Author) , Lämmle, Simon (Author) , Firneburg, Rebecca (Author) , Luo, Xiaojing (Author) , Künzel, Stephan R. (Author) , Klapproth, Erik (Author) , Mirtschink, Peter (Author) , Mayr, Manuel (Author) , Dewenter, Matthias (Author) , Vettel, Christiane (Author) , Heijman, Jordi (Author) , Lorenz, Kristina (Author) , Guan, Kaomei (Author) , El-Armouche, Ali (Author) , Wagner, Michael (Author) , Kämmerer, Susanne (Author) ,


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