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bcl-2 expression in non-Hodgkin's lymphomas is not associated with bcl-2 gene rearrangements

Previous reports have associated bcl-2 gene rearrangements found in non-Hodgkin's lymphomas with an inappropriately elevated bcl-2 expression compared with the mature B-cell stage of development. This study investigates bcl-2 expression in non-Hodgkin's lymphomas (NHL) without bcl-2 gene r...

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Main Authors: Papakonstantinou, Georgios (Author) , Verbeke, Caroline Sophie (Author) , Hastka, Jan (Author) , Bohrer, Manfred H. (Author) , Hehlmann, Rüdiger (Author)
Format: Article (Journal)
Language:English
Published: 2001
In: British journal of haematology
Year: 2001, Volume: 113, Issue: 2, Pages: 383-390
ISSN:1365-2141
DOI:10.1046/j.1365-2141.2001.02727.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1046/j.1365-2141.2001.02727.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2141.2001.02727.x
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Author Notes:Georgios Papakonstantinou, Caroline Verbeke, Jan Hastka, Manfred Bohrer and Rüdiger Hehlmann

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520 |a Previous reports have associated bcl-2 gene rearrangements found in non-Hodgkin's lymphomas with an inappropriately elevated bcl-2 expression compared with the mature B-cell stage of development. This study investigates bcl-2 expression in non-Hodgkin's lymphomas (NHL) without bcl-2 gene rearrangements. Molecular analysis in 168 patients with NHL revealed 45 patients without bcl-2 gene rearrangements in which additional immunostaining for bcl-2 protein was possible. An unexpectedly high prevalence (39/45) of bcl-2 expression was found. The levels and patterns of bcl-2 expression were not specific for the histological type of NHL and were similar to those shown in comparable cases with bcl-2 gene rearrangements. In conclusion, bcl-2 expression is not specific for NHL bearing bcl-2 gene rearrangements. This finding implicates the existence of other deregulating control mechanisms of bcl-2 expression, more important than bcl-2 gene rearrangements. 
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