Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-α
Recently, it was shown that interferon consensus sequence binding protein (ICSBP), a member of the interferon regulatory factor (IRF) family, has a potential role in chronic myeloid leukemia (CML). Deletion of ICSBP gene in mice leads to a CML-like syndrome and samples from CML patients exhibited im...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 1, 2001
|
| In: |
Blood
Year: 2001, Volume: 97, Issue: 11, Pages: 3648-3650 |
| ISSN: | 1528-0020 |
| DOI: | 10.1182/blood.V97.11.3648 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood.V97.11.3648
|
| Author Notes: | Manuel Schmidt, Andreas Hochhaus, Andreas Nitsche, Rüdiger Hehlmann, and Andreas Neubauer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1802477896 | ||
| 003 | DE-627 | ||
| 005 | 20220820184250.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220518s2001 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1182/blood.V97.11.3648 |2 doi | |
| 035 | |a (DE-627)1802477896 | ||
| 035 | |a (DE-599)KXP1802477896 | ||
| 035 | |a (OCoLC)1341460228 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schmidt, Manuel |e VerfasserIn |0 (DE-588)1255324902 |0 (DE-627)1799541479 |4 aut | |
| 245 | 1 | 0 | |a Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-α |c Manuel Schmidt, Andreas Hochhaus, Andreas Nitsche, Rüdiger Hehlmann, and Andreas Neubauer |
| 246 | 3 | 3 | |a Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-alpha |
| 264 | 1 | |c June 1, 2001 | |
| 300 | |a 3 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 18.05.2022 | ||
| 520 | |a Recently, it was shown that interferon consensus sequence binding protein (ICSBP), a member of the interferon regulatory factor (IRF) family, has a potential role in chronic myeloid leukemia (CML). Deletion of ICSBP gene in mice leads to a CML-like syndrome and samples from CML patients exhibited impaired ICSBP expression. The present study found that ICSBP expression correlated with risk features determined by Sokal score in untreated CML (P = .007 for high versus low risk). In addition, analyzing ICSBP expression during interferon-α (IFN-α) therapy in “good” (n = 27) versus “poor” (n = 15) cytogenetic responders, high ICSBP levels were only observed in “good” responders (P = .0002). Together, these data suggest that ICSBP levels are related to initial presentation of CML and the therapeutic response of CML to IFN-α, indicating an important role of ICSBP in CML. | ||
| 700 | 1 | |a Hochhaus, Andreas |d 1959- |e VerfasserIn |0 (DE-588)1107039339 |0 (DE-627)863321976 |0 (DE-576)474976130 |4 aut | |
| 700 | 1 | |a Nitsche, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hehlmann, Rüdiger |d 1941- |e VerfasserIn |0 (DE-588)1037003489 |0 (DE-627)751737879 |0 (DE-576)390939463 |4 aut | |
| 700 | 1 | |a Neubauer, Andreas |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Blood |d Washington, DC : American Society of Hematology, 1946 |g 97(2001), 11, Seite 3648-3650 |h Online-Ressource |w (DE-627)266886647 |w (DE-600)1468538-3 |w (DE-576)075961938 |x 1528-0020 |7 nnas |a Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-α |
| 773 | 1 | 8 | |g volume:97 |g year:2001 |g number:11 |g pages:3648-3650 |g extent:3 |a Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-α |
| 856 | 4 | 0 | |u https://doi.org/10.1182/blood.V97.11.3648 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220518 | ||
| 993 | |a Article | ||
| 994 | |a 2001 | ||
| 998 | |g 1037003489 |a Hehlmann, Rüdiger |m 1037003489:Hehlmann, Rüdiger |d 60000 |d 61200 |e 60000PH1037003489 |e 61200PH1037003489 |k 0/60000/ |k 1/60000/61200/ |p 4 | ||
| 998 | |g 1107039339 |a Hochhaus, Andreas |m 1107039339:Hochhaus, Andreas |d 60000 |d 61200 |e 60000PH1107039339 |e 61200PH1107039339 |k 0/60000/ |k 1/60000/61200/ |p 2 | ||
| 999 | |a KXP-PPN1802477896 |e 4135881262 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"titleAlt":[{"title":"Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-alpha"}],"language":["eng"],"person":[{"family":"Schmidt","display":"Schmidt, Manuel","given":"Manuel","role":"aut"},{"given":"Andreas","role":"aut","display":"Hochhaus, Andreas","family":"Hochhaus"},{"display":"Nitsche, Andreas","family":"Nitsche","given":"Andreas","role":"aut"},{"display":"Hehlmann, Rüdiger","family":"Hehlmann","given":"Rüdiger","role":"aut"},{"given":"Andreas","role":"aut","family":"Neubauer","display":"Neubauer, Andreas"}],"id":{"doi":["10.1182/blood.V97.11.3648"],"eki":["1802477896"]},"name":{"displayForm":["Manuel Schmidt, Andreas Hochhaus, Andreas Nitsche, Rüdiger Hehlmann, and Andreas Neubauer"]},"physDesc":[{"extent":"3 S."}],"relHost":[{"corporate":[{"display":"American Society of Hematology","role":"isb"}],"part":{"pages":"3648-3650","year":"2001","issue":"11","text":"97(2001), 11, Seite 3648-3650","volume":"97","extent":"3"},"titleAlt":[{"title":"Blood online"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-αBlood","title":[{"title":"Blood","title_sort":"Blood","subtitle":"journal of the American Society of Hematology"}],"origin":[{"publisherPlace":"Washington, DC ; Philadelphia, Pa. ; Stanford, Calif.","dateIssuedDisp":"1946-","publisher":"American Society of Hematology ; Saunders ; HighWire Press","dateIssuedKey":"1946"}],"pubHistory":["1.1946 -"],"note":["Gesehen am 21.04.2023"],"id":{"issn":["1528-0020"],"zdb":["1468538-3"],"eki":["266886647"]},"recId":"266886647","physDesc":[{"extent":"Online-Ressource"}]}],"recId":"1802477896","type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 18.05.2022"],"origin":[{"dateIssuedKey":"2001","dateIssuedDisp":"June 1, 2001"}],"title":[{"title_sort":"Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-α","title":"Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-α"}]} | ||
| SRT | |a SCHMIDTMANEXPRESSION1200 | ||