Glypican-1 drives unconventional secretion of fibroblast growth factor 2
Fibroblast growth factor 2 (FGF2) is a tumor cell survival factor that is transported into the extracellular space by an unconventional secretory mechanism. Cell surface heparan sulfate proteoglycans are known to play an essential role in this process. Unexpectedly, we found that among the diverse s...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 March 2022
|
| In: |
eLife
Year: 2022, Jahrgang: 11, Pages: 1-25 |
| ISSN: | 2050-084X |
| DOI: | 10.7554/eLife.75545 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.7554/eLife.75545
|
| Verfasserangaben: | Carola Sparn, Eleni Dimou, Annalena Meyer, Roberto Saleppico, Sabine Wegehingel, Matthias Gerstner, Severina Klaus, Helge Ewers, Walter Nickel |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1802581723 | ||
| 003 | DE-627 | ||
| 005 | 20220820185010.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220519s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.7554/eLife.75545 |2 doi | |
| 035 | |a (DE-627)1802581723 | ||
| 035 | |a (DE-599)KXP1802581723 | ||
| 035 | |a (OCoLC)1341460030 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Sparn, Carola |d 1994- |e VerfasserIn |0 (DE-588)125125487X |0 (DE-627)1788662466 |4 aut | |
| 245 | 1 | 0 | |a Glypican-1 drives unconventional secretion of fibroblast growth factor 2 |c Carola Sparn, Eleni Dimou, Annalena Meyer, Roberto Saleppico, Sabine Wegehingel, Matthias Gerstner, Severina Klaus, Helge Ewers, Walter Nickel |
| 264 | 1 | |c 29 March 2022 | |
| 300 | |a 25 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 19.05.2022 | ||
| 520 | |a Fibroblast growth factor 2 (FGF2) is a tumor cell survival factor that is transported into the extracellular space by an unconventional secretory mechanism. Cell surface heparan sulfate proteoglycans are known to play an essential role in this process. Unexpectedly, we found that among the diverse subclasses consisting of syndecans, perlecans, glypicans, and others, Glypican-1 (GPC1) is the principle and rate-limiting factor that drives unconventional secretion of FGF2. By contrast, we demonstrate GPC1 to be dispensable for FGF2 signaling into cells. We provide first insights into the structural basis for GPC1-dependent FGF2 secretion, identifying disaccharides with N-linked sulfate groups to be enriched in the heparan sulfate chains of GPC1 to which FGF2 binds with high affinity. Our findings have broad implications for the role of GPC1 as a key molecule in tumor progression. | ||
| 650 | 4 | |a biochemistry of biological membranes | |
| 650 | 4 | |a fibroblast growth factor 2 | |
| 650 | 4 | |a glypican | |
| 650 | 4 | |a phosphoinositides | |
| 650 | 4 | |a protein translocation across membranes | |
| 650 | 4 | |a unconventional protein secretion | |
| 700 | 1 | |a Dimou, Eleni |e VerfasserIn |4 aut | |
| 700 | 1 | |a Meyer, Annalena |d 1993- |e VerfasserIn |0 (DE-588)1205750096 |0 (DE-627)1691394114 |4 aut | |
| 700 | 1 | |a Saleppico, Roberto |d 1992- |e VerfasserIn |0 (DE-588)1215510276 |0 (DE-627)172668301X |4 aut | |
| 700 | 1 | |a Wegehingel, Sabine |e VerfasserIn |0 (DE-588)111215910X |0 (DE-627)866117032 |0 (DE-576)476411610 |4 aut | |
| 700 | 1 | |a Gerstner, Matthias |d 1992- |e VerfasserIn |0 (DE-588)1233018582 |0 (DE-627)1757466908 |4 aut | |
| 700 | 1 | |a Klaus, Severina |d 1993- |e VerfasserIn |0 (DE-588)1237501687 |0 (DE-627)1764213297 |4 aut | |
| 700 | 1 | |a Ewers, Helge |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nickel, Walter |e VerfasserIn |0 (DE-588)1060271311 |0 (DE-627)799356964 |0 (DE-576)416359817 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t eLife |d Cambridge : eLife Sciences Publications, 2012 |g 11(2022), Artikel-ID e75545, Seite 1-25 |h Online-Ressource |w (DE-627)728518384 |w (DE-600)2687154-3 |w (DE-576)372567576 |x 2050-084X |7 nnas |a Glypican-1 drives unconventional secretion of fibroblast growth factor 2 |
| 773 | 1 | 8 | |g volume:11 |g year:2022 |g elocationid:e75545 |g pages:1-25 |g extent:25 |a Glypican-1 drives unconventional secretion of fibroblast growth factor 2 |
| 856 | 4 | 0 | |u https://doi.org/10.7554/eLife.75545 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220519 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1060271311 |a Nickel, Walter |m 1060271311:Nickel, Walter |d 700000 |d 711000 |e 700000PN1060271311 |e 711000PN1060271311 |k 0/700000/ |k 1/700000/711000/ |p 9 |y j | ||
| 998 | |g 1237501687 |a Klaus, Severina |m 1237501687:Klaus, Severina |d 910000 |d 911700 |e 910000PK1237501687 |e 911700PK1237501687 |k 0/910000/ |k 1/910000/911700/ |p 7 | ||
| 998 | |g 1233018582 |a Gerstner, Matthias |m 1233018582:Gerstner, Matthias |p 6 | ||
| 998 | |g 111215910X |a Wegehingel, Sabine |m 111215910X:Wegehingel, Sabine |d 700000 |d 711000 |e 700000PW111215910X |e 711000PW111215910X |k 0/700000/ |k 1/700000/711000/ |p 5 | ||
| 998 | |g 1215510276 |a Saleppico, Roberto |m 1215510276:Saleppico, Roberto |d 500000 |d 510186 |e 500000PS1215510276 |e 510186PS1215510276 |k 0/500000/ |k 1/500000/510186/ |p 4 | ||
| 998 | |g 1205750096 |a Meyer, Annalena |m 1205750096:Meyer, Annalena |d 500000 |d 510186 |e 500000PM1205750096 |e 510186PM1205750096 |k 0/500000/ |k 1/500000/510186/ |p 3 | ||
| 998 | |g 125125487X |a Sparn, Carola |m 125125487X:Sparn, Carola |d 140000 |e 140000PS125125487X |k 0/140000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1802581723 |e 4136143214 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title_sort":"Glypican-1 drives unconventional secretion of fibroblast growth factor 2","title":"Glypican-1 drives unconventional secretion of fibroblast growth factor 2"}],"name":{"displayForm":["Carola Sparn, Eleni Dimou, Annalena Meyer, Roberto Saleppico, Sabine Wegehingel, Matthias Gerstner, Severina Klaus, Helge Ewers, Walter Nickel"]},"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"29 March 2022"}],"id":{"eki":["1802581723"],"doi":["10.7554/eLife.75545"]},"relHost":[{"id":{"zdb":["2687154-3"],"issn":["2050-084X"],"eki":["728518384"]},"part":{"text":"11(2022), Artikel-ID e75545, Seite 1-25","volume":"11","pages":"1-25","year":"2022","extent":"25"},"origin":[{"dateIssuedDisp":"2012-","publisherPlace":"Cambridge","publisher":"eLife Sciences Publications","dateIssuedKey":"2012"}],"title":[{"title":"eLife","title_sort":"eLife"}],"pubHistory":["1.2012 -"],"titleAlt":[{"title":"eLife journal"}],"note":["Gesehen am 28.06.17"],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"recId":"728518384","type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Glypican-1 drives unconventional secretion of fibroblast growth factor 2eLife"}],"recId":"1802581723","language":["eng"],"physDesc":[{"extent":"25 S."}],"person":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Sparn, Carola","given":"Carola","family":"Sparn"},{"given":"Eleni","family":"Dimou","roleDisplay":"VerfasserIn","role":"aut","display":"Dimou, Eleni"},{"family":"Meyer","given":"Annalena","role":"aut","roleDisplay":"VerfasserIn","display":"Meyer, Annalena"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Saleppico, Roberto","given":"Roberto","family":"Saleppico"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Wegehingel, Sabine","given":"Sabine","family":"Wegehingel"},{"display":"Gerstner, Matthias","role":"aut","roleDisplay":"VerfasserIn","family":"Gerstner","given":"Matthias"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Klaus, Severina","family":"Klaus","given":"Severina"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Ewers, Helge","family":"Ewers","given":"Helge"},{"display":"Nickel, Walter","role":"aut","roleDisplay":"VerfasserIn","family":"Nickel","given":"Walter"}],"note":["Gesehen am 19.05.2022"]} | ||
| SRT | |a SPARNCAROLGLYPICAN1D2920 | ||