Trial of IFN or STI571 before proceeding to allografting for CML?
Ten-year survival of IFN-treated low risk CML patients is about 40%, and more in cytogenetic responders. Allografting has a cure rate of up to 75%, but is associated with considerable procedure related morbidity and mortality. One out of three or four is likely not to survive. A comparative quantifi...
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
31 August 2000
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| In: |
Leukemia
Year: 2000, Jahrgang: 14, Heft: 9, Pages: 1560-1562 |
| ISSN: | 1476-5551 |
| DOI: | 10.1038/sj.leu.2401874 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/sj.leu.2401874 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/2401874 
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| Verfasserangaben: | R. Hehlmann |
| Zusammenfassung: | Ten-year survival of IFN-treated low risk CML patients is about 40%, and more in cytogenetic responders. Allografting has a cure rate of up to 75%, but is associated with considerable procedure related morbidity and mortality. One out of three or four is likely not to survive. A comparative quantification of survival after BMT and IFN treatment suggests that a trial of IFN (and possibly STI 571) before proceeding to allografting is a viable, and in low risk patients a probably preferable option. |
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| Beschreibung: | Gesehen am 19.05.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 1476-5551 |
| DOI: | 10.1038/sj.leu.2401874 |