Association of F2-isoprostane levels with Alzheimer’s disease in observational studies: a systematic review and meta-analysis
Introduction - The association between F2-isoprostanes and Alzheimer’s disease (AD) has been controversially discussed in the literature since the 1990s. However, no systematic review has been performed so far. - Methods - A systematic review of observational studies on the associations of F2-isopro...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2022
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| In: |
Ageing research reviews
Year: 2022, Volume: 74, Pages: 1-9 |
| ISSN: | 1872-9649 |
| DOI: | 10.1016/j.arr.2021.101552 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.arr.2021.101552 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1568163721002993 
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| Author Notes: | Kira Trares, Li-Ju Chen, Ben Schöttker |
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| 520 | |a Introduction - The association between F2-isoprostanes and Alzheimer’s disease (AD) has been controversially discussed in the literature since the 1990s. However, no systematic review has been performed so far. - Methods - A systematic review of observational studies on the associations of F2-isoprostanes and the specific biomarker 8-iso-prostaglandin F2α with AD were conducted. Random-effects model meta-analyses were performed. - Results - 29 studies were included in the systematic review, including four longitudinal studies. In an overall meta-analysis of the 25 cross-sectional studies, F2-isoprostane levels were statistically significantly associated with AD (Hedge’s g [95% confidence interval]: 1.00 [0.69-1.32]). When studies were grouped by biomarker and sample specimen, F2-isoprostane and 8-iso-prostaglandin F2α levels were statistically significantly elevated in tissue samples of the frontal lobe of AD patients. Moreover, F2-isoprostane levels in cerebrospinal fluid and 8-iso-prostaglandin F2α levels in blood samples of AD patients were significantly increased. Meta-analyses of the few longitudinal studies did not reach statistical significance. - Discussion - Increased concentrations of F2-isoprostanes were found in AD patients. However, due to the lack of adjustment in most cross-sectional case-control studies, results must be interpreted carefully. In addition, the causality of the association is uncertain because evidence from well-conducted longitudinal studies was conflicting, and further longitudinal studies are required to reinforce the results. | ||
| 650 | 4 | |a 8-iso-prostaglandin F | |
| 650 | 4 | |a Alzheimer’s Disease | |
| 650 | 4 | |a F-isoprostanes | |
| 650 | 4 | |a Observational studies | |
| 650 | 4 | |a Oxidative stress | |
| 650 | 4 | |a Systematic review | |
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