Microinjection of alpha-MSH followed by UV-irradiation blocks HSP 72 in human keratinocytes
The aim of this study was to investigate the interaction of alpha-melanocyte-stimulating hormone (α-MSH) and heat shock protein 72 (HSP 72) in human keratinocytes in order to learn about the link between the neuroimmunocutaneus system and UV-induced immunomodulation. 1-3α-MSH, a proopiomelanocortin...
Gespeichert in:
| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) Konferenzschrift |
| Sprache: | Englisch |
| Veröffentlicht: |
1999
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| In: |
Annals of the New York Academy of Sciences
Year: 1999, Jahrgang: 885, Pages: 400-404 |
| ISSN: | 1749-6632 |
| DOI: | 10.1111/j.1749-6632.1999.tb08699.x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1749-6632.1999.tb08699.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.1999.tb08699.x 
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| Verfasserangaben: | Björn Held, Susanne Amato, Ernst G. Jung, and Christiane Bayerl |
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| 245 | 1 | 0 | |a Microinjection of alpha-MSH followed by UV-irradiation blocks HSP 72 in human keratinocytes |c Björn Held, Susanne Amato, Ernst G. Jung, and Christiane Bayerl |
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| 520 | |a The aim of this study was to investigate the interaction of alpha-melanocyte-stimulating hormone (α-MSH) and heat shock protein 72 (HSP 72) in human keratinocytes in order to learn about the link between the neuroimmunocutaneus system and UV-induced immunomodulation. 1-3α-MSH, a proopiomelanocortin (POMC) derived neuropeptide, 4 is produced in human keratinocytes 5, 6 as well as in normal and pathologic human skin. 7 It is upregulated by UV-irradiation, 8 and it is a potent mediator of inflammation 9, 10 and immune response. 3, 11 HSP 72, a chaperoning protein that has protective properties on cells, 12, 13 is upregulated by environmental stresses such as heat, UV-irradiation, drugs, and chemicals. 12, 14 Orel et al., 13 showed that there are inverse interactions between α-MSH and HSP 72 in the HaCat cell line. Therefore, we microinjected α-MSH into primary human keratinocytes in culture so as to study changes in HSP 72 at the protein level. | ||
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