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Microinjection of alpha-MSH followed by UV-irradiation blocks HSP 72 in human keratinocytes

The aim of this study was to investigate the interaction of alpha-melanocyte-stimulating hormone (α-MSH) and heat shock protein 72 (HSP 72) in human keratinocytes in order to learn about the link between the neuroimmunocutaneus system and UV-induced immunomodulation. 1-3α-MSH, a proopiomelanocortin...

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Bibliographic Details
Main Authors: Held, Björn (Author) , Amato, Susanne (Author) , Jung, Ernst G. (Author) , Bayerl, Christiane (Author)
Format: Article (Journal) Conference Paper
Language:English
Published: 1999
In: Annals of the New York Academy of Sciences
Year: 1999, Volume: 885, Pages: 400-404
ISSN:1749-6632
DOI:10.1111/j.1749-6632.1999.tb08699.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1749-6632.1999.tb08699.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.1999.tb08699.x
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Author Notes:Björn Held, Susanne Amato, Ernst G. Jung, and Christiane Bayerl

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520 |a The aim of this study was to investigate the interaction of alpha-melanocyte-stimulating hormone (α-MSH) and heat shock protein 72 (HSP 72) in human keratinocytes in order to learn about the link between the neuroimmunocutaneus system and UV-induced immunomodulation. 1-3α-MSH, a proopiomelanocortin (POMC) derived neuropeptide, 4 is produced in human keratinocytes 5, 6 as well as in normal and pathologic human skin. 7 It is upregulated by UV-irradiation, 8 and it is a potent mediator of inflammation 9, 10 and immune response. 3, 11 HSP 72, a chaperoning protein that has protective properties on cells, 12, 13 is upregulated by environmental stresses such as heat, UV-irradiation, drugs, and chemicals. 12, 14 Orel et al., 13 showed that there are inverse interactions between α-MSH and HSP 72 in the HaCat cell line. Therefore, we microinjected α-MSH into primary human keratinocytes in culture so as to study changes in HSP 72 at the protein level. 
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