Changes of breath volatile organic compounds in healthy volunteers following segmental and inhalation endotoxin challenge
It is still unclear how airway inflammation affects the breath volatile organic compounds (VOCs) profile in exhaled air. We therefore analyzed breath following well-defined pulmonary endotoxin (lipopolysaccharide, LPS) challenges. Breath was collected from ten healthy non-smoking subjects at eight t...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 May 2022
|
| In: |
Journal of breath research
Year: 2022, Jahrgang: 16, Heft: 3, Pages: 1-17 |
| ISSN: | 1752-7163 |
| DOI: | 10.1088/1752-7163/ac6359 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1088/1752-7163/ac6359
|
| Verfasserangaben: | Olaf Holz, Robert van Vorstenbosch, Frank Guenther, Sven Schuchardt, Frederik Trinkmann, Frederik-Jan van Schooten, Agnieszka Smolinska and Jens M. Hohlfeld |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1804098272 | ||
| 003 | DE-627 | ||
| 005 | 20230427164145.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220523s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1088/1752-7163/ac6359 |2 doi | |
| 035 | |a (DE-627)1804098272 | ||
| 035 | |a (DE-599)KXP1804098272 | ||
| 035 | |a (OCoLC)1341460163 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Holz, Olaf |d 1962- |e VerfasserIn |0 (DE-588)131363727 |0 (DE-627)508485711 |0 (DE-576)298430703 |4 aut | |
| 245 | 1 | 0 | |a Changes of breath volatile organic compounds in healthy volunteers following segmental and inhalation endotoxin challenge |c Olaf Holz, Robert van Vorstenbosch, Frank Guenther, Sven Schuchardt, Frederik Trinkmann, Frederik-Jan van Schooten, Agnieszka Smolinska and Jens M. Hohlfeld |
| 264 | 1 | |c 3 May 2022 | |
| 300 | |a 17 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 23.05.2022 | ||
| 520 | |a It is still unclear how airway inflammation affects the breath volatile organic compounds (VOCs) profile in exhaled air. We therefore analyzed breath following well-defined pulmonary endotoxin (lipopolysaccharide, LPS) challenges. Breath was collected from ten healthy non-smoking subjects at eight time points before and after segmental and whole lung LPS inhalation challenge. Four Tenax-TA® adsorption tubes were simultaneously loaded from an aluminum reservoir cylinder and independently analyzed by two research groups using gas chromatography—mass spectrometry. Airway inflammation was assessed in bronchoalveolar lavage (BAL) and in sputum after segmental and inhaled LPS challenge, respectively. Segmental LPS challenge significantly increased the median (interquartile range, IQR) percentage of neutrophils in BAL from 3.0 (4.2) % to 64.0 (7.3) %. The inhalation challenge increased sputum neutrophils from 33.9 (26.8) % to 78.3 (13.5) %. We observed increases in breath aldehydes at both time points after segmental and inhaled LPS challenge. These results were confirmed by an independent laboratory. The longitudinal breath analysis also revealed distinct VOC patterns related to environmental exposures, clinical procedures, and to metabolic changes after food intake. Changes in breath aldehydes suggest a relationship to LPS induced inflammation compatible with lipid peroxidation processes within the lung. Findings from our longitudinal data highlight the need for future studies to better consider the potential impact of the multiple VOCs from detergents, hygiene or lifestyle products a subject is continuously exposed to. We suspect that this very individual ‘owncloud’ exposure is contributing to an increased variability of breath aldehydes, which might limit a use as inflammatory markers in daily clinical practice. | ||
| 700 | 1 | |a Vorstenbosch, Robert van |e VerfasserIn |4 aut | |
| 700 | 1 | |a Guenther, Frank |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schuchardt, Sven |e VerfasserIn |4 aut | |
| 700 | 1 | |a Trinkmann, Frederik |d 1983- |e VerfasserIn |0 (DE-588)142731773 |0 (DE-627)704298066 |0 (DE-576)332907406 |4 aut | |
| 700 | 1 | |a Schooten, Frederik-Jan van |e VerfasserIn |4 aut | |
| 700 | 1 | |a Smolinska, Agnieszka |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hohlfeld, Jens M. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of breath research |d Bristol : IOP, 2007 |g 16(2022), 3, Artikel-ID 037102, Seite 1-17 |h Online-Ressource |w (DE-627)53899889X |w (DE-600)2381007-5 |w (DE-576)276561082 |x 1752-7163 |7 nnas |a Changes of breath volatile organic compounds in healthy volunteers following segmental and inhalation endotoxin challenge |
| 773 | 1 | 8 | |g volume:16 |g year:2022 |g number:3 |g elocationid:037102 |g pages:1-17 |g extent:17 |a Changes of breath volatile organic compounds in healthy volunteers following segmental and inhalation endotoxin challenge |
| 856 | 4 | 0 | |u https://doi.org/10.1088/1752-7163/ac6359 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220523 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 142731773 |a Trinkmann, Frederik |m 142731773:Trinkmann, Frederik |d 910000 |d 950000 |d 950900 |d 60000 |d 61000 |e 910000PT142731773 |e 950000PT142731773 |e 950900PT142731773 |e 60000PT142731773 |e 61000PT142731773 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/60000/ |k 1/60000/61000/ |p 5 | ||
| 999 | |a KXP-PPN1804098272 |e 4138105344 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Olaf Holz, Robert van Vorstenbosch, Frank Guenther, Sven Schuchardt, Frederik Trinkmann, Frederik-Jan van Schooten, Agnieszka Smolinska and Jens M. Hohlfeld"]},"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"3 May 2022"}],"recId":"1804098272","id":{"eki":["1804098272"],"doi":["10.1088/1752-7163/ac6359"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"given":"Olaf","role":"aut","family":"Holz","display":"Holz, Olaf"},{"given":"Robert van","display":"Vorstenbosch, Robert van","role":"aut","family":"Vorstenbosch"},{"given":"Frank","role":"aut","family":"Guenther","display":"Guenther, Frank"},{"display":"Schuchardt, Sven","role":"aut","family":"Schuchardt","given":"Sven"},{"given":"Frederik","display":"Trinkmann, Frederik","role":"aut","family":"Trinkmann"},{"role":"aut","family":"Schooten","display":"Schooten, Frederik-Jan van","given":"Frederik-Jan van"},{"role":"aut","family":"Smolinska","display":"Smolinska, Agnieszka","given":"Agnieszka"},{"given":"Jens M.","display":"Hohlfeld, Jens M.","family":"Hohlfeld","role":"aut"}],"note":["Gesehen am 23.05.2022"],"language":["eng"],"physDesc":[{"extent":"17 S."}],"title":[{"title_sort":"Changes of breath volatile organic compounds in healthy volunteers following segmental and inhalation endotoxin challenge","title":"Changes of breath volatile organic compounds in healthy volunteers following segmental and inhalation endotoxin challenge"}],"relHost":[{"title":[{"title":"Journal of breath research","subtitle":"volatiles for medical diagnosis ; official journal of the International Association for Breath Research (IABR) and the International Society for Breath Odor Research (ISBOR)","title_sort":"Journal of breath research"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"volume":"16","text":"16(2022), 3, Artikel-ID 037102, Seite 1-17","extent":"17","issue":"3","pages":"1-17","year":"2022"},"language":["eng"],"note":["Gesehen am 04.03.2021","Fortsetzung der Druck-Ausgabe"],"pubHistory":["1.2007 -"],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"53899889X","id":{"zdb":["2381007-5"],"eki":["53899889X"],"issn":["1752-7163"]},"origin":[{"publisher":"IOP","dateIssuedDisp":"2007-","dateIssuedKey":"2007","publisherPlace":"Bristol"}],"disp":"Changes of breath volatile organic compounds in healthy volunteers following segmental and inhalation endotoxin challengeJournal of breath research"}]} | ||
| SRT | |a HOLZOLAFVOCHANGESOFB3202 | ||