Monitoring of lung edema by microwave reflectometry during lung ischemia-reperfusion injury in vivo
It is still unclear whether lung edema can be monitored by microwave reflectometry and whether the measured changes in lung dry matter content (DMC) are accompanied by changes in PaO<sub>2</sub> and in pro- to anti-inflammatory cytokine expression (IFN-γ and IL-10). Right rat lung hili w...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 2006
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| In: |
European surgical research
Year: 2006, Jahrgang: 38, Heft: 1, Pages: 18-26 |
| ISSN: | 1421-9921 |
| DOI: | 10.1159/000091481 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000091481 Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/91481 
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| Verfasserangaben: | Kai Nowak, Michael Schaefer, Wolfgang Gross, Roman Patrick Metzger, Peter Hohenberger, Stefan Post, Martha Maria Gebhard |
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| 520 | |a It is still unclear whether lung edema can be monitored by microwave reflectometry and whether the measured changes in lung dry matter content (DMC) are accompanied by changes in PaO<sub>2</sub> and in pro- to anti-inflammatory cytokine expression (IFN-γ and IL-10). Right rat lung hili were cross-clamped at 37°C for 0, 60, 90 or 120 min ischemia followed by 120 min reperfusion. After 90 min (DMC: 15.9 ± 1.4%; PaO<sub>2</sub>: 76.7 ± 18 mm Hg) and 120 min ischemia (DMC: 12.8 ± 0.6%; PaO<sub>2</sub>: 43 ± 7 mm Hg), a significant decrease in DMC and PaO<sub>2</sub> throughout reperfusion compared to 0 min ischemia (DMC: 19.5 ± 1.11%; PaO<sub>2</sub>: 247 ± 33 mm Hg; p < 0.05) was observed. DMC and PaO<sub>2</sub> decreased after 60 min ischemia but recovered during reperfusion (DMC: 18.5 ± 2.4%; PaO<sub>2</sub>: 173 ± 30 mm Hg). DMC values reflected changes on the physiological and molecular level. In conclusion, lung edema monitoring by microwave reflectometry might become a tool for the thoracic surgeon. | ||
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