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Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer

The nonoxidative pentose phosphate pathway allows glucose conversion to ribose for DNA or RNA synthesis and glucose degradation to lactate controlled by transketolase enzyme reactions. It has been postulated, that this pathway is of the utmost importance in tumors for the proliferation process. We d...

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Main Authors: Staiger, Wilko (Author) , Coy, Johannes F. (Author) , Grobholz, Rainer (Author) , Hofheinz, Ralf-Dieter (Author) , Lukan, Nadine (Author) , Post, Stefan (Author) , Schwarzbach, Matthias (Author) , Willeke, Frank (Author)
Format: Article (Journal)
Language:English
Published: October 1, 2006
In: Oncology reports
Year: 2006, Volume: 16, Issue: 4, Pages: 657-661
ISSN:1791-2431
DOI:10.3892/or.16.4.657
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3892/or.16.4.657
Verlag, lizenzpflichtig, Volltext: https://www.spandidos-publications.com/10.3892/or.16.4.657
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Author Notes:Wilko I. Staiger, Johannes F. Coy, Rainer Grobholz, Ralf-Dieter Hofheinz, Nadine Lukan, Stefan Post, Matthias H. Schwarzbach and Frank Willeke
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Summary:The nonoxidative pentose phosphate pathway allows glucose conversion to ribose for DNA or RNA synthesis and glucose degradation to lactate controlled by transketolase enzyme reactions. It has been postulated, that this pathway is of the utmost importance in tumors for the proliferation process. We detected a strong upregulation of the mutated transketolase transcript (TKTL1) in a considerable number of patients with gastric cancer (GC) or cancer of the gastroesophageal junction (GEJ). While only 10.8% of the cancer tissues revealed a significant mRNA upregulation, 36.9% of the cancer tissues demonstrated a protein overexpression. We propose that TKTL1 upregulation is a common phenomenon in GC and cancer of the GEJ leading to an enhanced, oxygen-independent glucose usage which might contribute to a more aggressive tumor growth. Since molecular targeted inhibition of transketolase enzyme reactions suppresses tumor growth and metastasis, TKTL1 could be a relevant target for anti-transketolase therapies in gastric cancer.
Item Description:Gesehen am 30.05.2022
Physical Description:Online Resource
ISSN:1791-2431
DOI:10.3892/or.16.4.657

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