Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer
The nonoxidative pentose phosphate pathway allows glucose conversion to ribose for DNA or RNA synthesis and glucose degradation to lactate controlled by transketolase enzyme reactions. It has been postulated, that this pathway is of the utmost importance in tumors for the proliferation process. We d...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 1, 2006
|
| In: |
Oncology reports
Year: 2006, Jahrgang: 16, Heft: 4, Pages: 657-661 |
| ISSN: | 1791-2431 |
| DOI: | 10.3892/or.16.4.657 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3892/or.16.4.657 Verlag, lizenzpflichtig, Volltext: https://www.spandidos-publications.com/10.3892/or.16.4.657 
|
| Verfasserangaben: | Wilko I. Staiger, Johannes F. Coy, Rainer Grobholz, Ralf-Dieter Hofheinz, Nadine Lukan, Stefan Post, Matthias H. Schwarzbach and Frank Willeke |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1805185349 | ||
| 003 | DE-627 | ||
| 005 | 20220820192720.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220530s2006 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3892/or.16.4.657 |2 doi | |
| 035 | |a (DE-627)1805185349 | ||
| 035 | |a (DE-599)KXP1805185349 | ||
| 035 | |a (OCoLC)1341460575 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Staiger, Wilko |d 1973- |e VerfasserIn |0 (DE-588)124635083 |0 (DE-627)363459278 |0 (DE-576)294423311 |4 aut | |
| 245 | 1 | 0 | |a Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer |c Wilko I. Staiger, Johannes F. Coy, Rainer Grobholz, Ralf-Dieter Hofheinz, Nadine Lukan, Stefan Post, Matthias H. Schwarzbach and Frank Willeke |
| 264 | 1 | |c October 1, 2006 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 30.05.2022 | ||
| 520 | |a The nonoxidative pentose phosphate pathway allows glucose conversion to ribose for DNA or RNA synthesis and glucose degradation to lactate controlled by transketolase enzyme reactions. It has been postulated, that this pathway is of the utmost importance in tumors for the proliferation process. We detected a strong upregulation of the mutated transketolase transcript (TKTL1) in a considerable number of patients with gastric cancer (GC) or cancer of the gastroesophageal junction (GEJ). While only 10.8% of the cancer tissues revealed a significant mRNA upregulation, 36.9% of the cancer tissues demonstrated a protein overexpression. We propose that TKTL1 upregulation is a common phenomenon in GC and cancer of the GEJ leading to an enhanced, oxygen-independent glucose usage which might contribute to a more aggressive tumor growth. Since molecular targeted inhibition of transketolase enzyme reactions suppresses tumor growth and metastasis, TKTL1 could be a relevant target for anti-transketolase therapies in gastric cancer. | ||
| 700 | 1 | |a Coy, Johannes F. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grobholz, Rainer |e VerfasserIn |0 (DE-588)1068350679 |0 (DE-627)820163538 |0 (DE-576)427721032 |4 aut | |
| 700 | 1 | |a Hofheinz, Ralf-Dieter |d 1969- |e VerfasserIn |0 (DE-588)121917517 |0 (DE-627)08161876X |0 (DE-576)292991568 |4 aut | |
| 700 | 1 | |a Lukan, Nadine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Post, Stefan |d 1954- |e VerfasserIn |0 (DE-588)1026227518 |0 (DE-627)726294667 |0 (DE-576)371524598 |4 aut | |
| 700 | 1 | |a Schwarzbach, Matthias |d 1966- |e VerfasserIn |0 (DE-588)1077763433 |0 (DE-627)837470064 |0 (DE-576)184627036 |4 aut | |
| 700 | 1 | |a Willeke, Frank |d 1963- |e VerfasserIn |0 (DE-588)1084359758 |0 (DE-627)848798902 |0 (DE-576)170761568 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Oncology reports |d Athens : Spandidos Publ., 1994 |g 16(2006), 4, Seite 657-661 |h Online-Ressource |w (DE-627)371095077 |w (DE-600)2120548-6 |w (DE-576)27824159X |x 1791-2431 |7 nnas |a Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer |
| 773 | 1 | 8 | |g volume:16 |g year:2006 |g number:4 |g pages:657-661 |g extent:5 |a Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer |
| 856 | 4 | 0 | |u https://doi.org/10.3892/or.16.4.657 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.spandidos-publications.com/10.3892/or.16.4.657 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220530 | ||
| 993 | |a Article | ||
| 994 | |a 2006 | ||
| 998 | |g 1084359758 |a Willeke, Frank |m 1084359758:Willeke, Frank |d 60000 |d 61800 |e 60000PW1084359758 |e 61800PW1084359758 |k 0/60000/ |k 1/60000/61800/ |p 8 |y j | ||
| 998 | |g 1077763433 |a Schwarzbach, Matthias |m 1077763433:Schwarzbach, Matthias |d 60000 |d 61800 |e 60000PS1077763433 |e 61800PS1077763433 |k 0/60000/ |k 1/60000/61800/ |p 7 | ||
| 998 | |g 1026227518 |a Post, Stefan |m 1026227518:Post, Stefan |d 60000 |d 61800 |e 60000PP1026227518 |e 61800PP1026227518 |k 0/60000/ |k 1/60000/61800/ |p 6 | ||
| 998 | |g 121917517 |a Hofheinz, Ralf-Dieter |m 121917517:Hofheinz, Ralf-Dieter |d 60000 |d 61200 |e 60000PH121917517 |e 61200PH121917517 |k 0/60000/ |k 1/60000/61200/ |p 4 | ||
| 998 | |g 1068350679 |a Grobholz, Rainer |m 1068350679:Grobholz, Rainer |d 60000 |d 63400 |e 60000PG1068350679 |e 63400PG1068350679 |k 0/60000/ |k 1/60000/63400/ |p 3 | ||
| 999 | |a KXP-PPN1805185349 |e 4141410276 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer","title":"Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer"}],"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"eki":["371095077"],"issn":["1791-2431"],"zdb":["2120548-6"]},"part":{"extent":"5","year":"2006","volume":"16","text":"16(2006), 4, Seite 657-661","pages":"657-661","issue":"4"},"pubHistory":["Volume 1, issue 1 (January 1994) -"],"origin":[{"publisherPlace":"Athens","dateIssuedDisp":"[1994]-","publisher":"Spandidos Publ."}],"recId":"371095077","physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Oncology reports","title":"Oncology reports"}],"language":["eng"],"disp":"Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancerOncology reports","note":["Volltext auch als Teil einer Datenbank verfügbar","Gesehen am 12.06.2025"]}],"physDesc":[{"extent":"5 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1805185349"],"doi":["10.3892/or.16.4.657"]},"language":["eng"],"person":[{"role":"aut","display":"Staiger, Wilko","given":"Wilko","family":"Staiger"},{"role":"aut","display":"Coy, Johannes F.","given":"Johannes F.","family":"Coy"},{"role":"aut","display":"Grobholz, Rainer","given":"Rainer","family":"Grobholz"},{"family":"Hofheinz","given":"Ralf-Dieter","display":"Hofheinz, Ralf-Dieter","role":"aut"},{"family":"Lukan","given":"Nadine","display":"Lukan, Nadine","role":"aut"},{"given":"Stefan","family":"Post","role":"aut","display":"Post, Stefan"},{"family":"Schwarzbach","given":"Matthias","display":"Schwarzbach, Matthias","role":"aut"},{"family":"Willeke","given":"Frank","display":"Willeke, Frank","role":"aut"}],"origin":[{"dateIssuedKey":"2006","dateIssuedDisp":"October 1, 2006"}],"note":["Gesehen am 30.05.2022"],"recId":"1805185349","name":{"displayForm":["Wilko I. Staiger, Johannes F. Coy, Rainer Grobholz, Ralf-Dieter Hofheinz, Nadine Lukan, Stefan Post, Matthias H. Schwarzbach and Frank Willeke"]}} | ||
| SRT | |a STAIGERWILEXPRESSION1200 | ||