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Biodegradation of absorbable sutures in body fluids and pH buffers

Objective: This study measures the influence of body fluids on the loss of tensile strength of absorbable sutures in vitro. Methods: Nine synthetic absorbable sutures were incubated in different gastrointestinal fluids, as well as in blood and three buffers. Stretch tests were performed after days 0...

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Bibliographic Details
Main Authors: Freudenberg, Sebastian (Author) , Rewerk, Stephan (Author) , Kaess, Michael (Author) , Weiß, Christel (Author) , Dorn-Beinecke, A. (Author) , Post, Stefan (Author)
Format: Article (Journal)
Language:English
Published: 2004
In: European surgical research
Year: 2004, Volume: 36, Issue: 6, Pages: 376-385
ISSN:1421-9921
DOI:10.1159/000081648
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000081648
Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/81648
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Author Notes:S. Freudenberg, S. Rewerk, M. Kaess, Christel Weiss, A. Dorn-Beinecke, S. Post

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520 |a Objective: This study measures the influence of body fluids on the loss of tensile strength of absorbable sutures in vitro. Methods: Nine synthetic absorbable sutures were incubated in different gastrointestinal fluids, as well as in blood and three buffers. Stretch tests were performed after days 0, 7, 14, and 21. Results: Tensile strength varied from 18.5 to 32.8 N, and elasticity varied from 9.5 to 51% of the initial length. The influence of pH, blood, and gastric juice was negligible on all sutures except PDS II®. Except for Monocryl®, all sutures, especially Polysorb® and Vicryl®, lost tensile strength much faster in bile, jejunal and pancreatic juices than in the corresponding buffers. Conclusion: The biodegradation of sutures varies greatly in different body fluids independent of differences in pH. 
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