Expression and activity of matrix metalloproteinases-2 and -9 in serum, core needle biopsies and tissue specimens of prostate cancer patients
Prostate cancer is the most common cancer in men and second in the cancer-related frequency of mortality. Matrix metalloproteinases (MMPs) are involved in tumor invasion and metastasis in various malignancies. MMP-2 and MMP-9 are capable of digesting collagen type IV. Numerous studies have demonstra...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 April 2004
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| In: |
Virchows Archiv
Year: 2004, Jahrgang: 444, Heft: 6, Pages: 518-526 |
| ISSN: | 1432-2307 |
| DOI: | 10.1007/s00428-004-1016-2 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00428-004-1016-2
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| Verfasserangaben: | Christian G. Sauer, Alexandra Kappeler, Monika Späth, Jens J. Kaden, Maurice S. Michel, Doris Mayer, Uwe Bleyl, Rainer Grobholz |
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| 245 | 1 | 0 | |a Expression and activity of matrix metalloproteinases-2 and -9 in serum, core needle biopsies and tissue specimens of prostate cancer patients |c Christian G. Sauer, Alexandra Kappeler, Monika Späth, Jens J. Kaden, Maurice S. Michel, Doris Mayer, Uwe Bleyl, Rainer Grobholz |
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| 520 | |a Prostate cancer is the most common cancer in men and second in the cancer-related frequency of mortality. Matrix metalloproteinases (MMPs) are involved in tumor invasion and metastasis in various malignancies. MMP-2 and MMP-9 are capable of digesting collagen type IV. Numerous studies have demonstrated an association between increased MMP-2 and -9 expression and tumor progression in various tumors. In this study, the expression and activities of MMP-2 and -9 were assessed in serum probes and tumor tissue from core needle biopsies and radical prostatectomies of 97 patients. MMP-2 and -9 serum expression was analyzed in a subgroup of 31 patients. MMP-9 serum expression was significantly increased in tumor patients and correlated with tumor grade. In contrast, the MMP-9 tissue expression and activity revealed no significant correlations to tumor stage or grade. The MMP-2 activity, however, showed a positive correlation for MMP-2 with tumor stage. Increased activity was predominantly detected in advanced tumor stages. Immunohistochemical analysis of MMP-2 expression demonstrated a positive association with tumor grade in prostatectomy specimens. The relative expression rates in biopsies matched in 65% with those of the prostatectomies. Detection of MMP-2 in core needle biopsies seems not to be a helpful marker for diagnostic purposes. | ||
| 650 | 4 | |a Gelatin zymography | |
| 650 | 4 | |a Immunohistochemistry | |
| 650 | 4 | |a Matrix metalloproteinases | |
| 650 | 4 | |a Prostatic carcinoma | |
| 650 | 4 | |a Western blot | |
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