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Cyclosporine nephrotoxicity

Cyclosporine (CsA) is the current primary immunosuppressant for the prevention of allograft rejection in solid organ transplantation. However, owing to its molecular mechanism of action the drug is associated with various adverse side effects (eg, nephrotoxicity). Histological changes appear as obli...

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Hauptverfasser: Busauschina, Aigerim (VerfasserIn) , Schnülle, Peter (VerfasserIn) , Woude, Fokko J. van der (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2004
In: Transplantation proceedings
Year: 2004, Jahrgang: 36, Pages: 229-233
ISSN:1873-2623
DOI:10.1016/j.transproceed.2004.01.021
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.transproceed.2004.01.021
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0041134504000223
Volltext
Verfasserangaben:A. Busauschina, P. Schnuelle, and F.J. van der Woude

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520 |a Cyclosporine (CsA) is the current primary immunosuppressant for the prevention of allograft rejection in solid organ transplantation. However, owing to its molecular mechanism of action the drug is associated with various adverse side effects (eg, nephrotoxicity). Histological changes appear as obliterative vasculopathy of the afferent arteriole and tubulointerstitial fibrosis in advanced cases. The underlying pathomechanisms of this condition reflect an altered release of vasoactive substances, such as angiotensin II, endothelin, prostaglandins, and nitric oxide as well as the stimulation of proliferative genes such as transforming growth factor-beta, osteopontin, and collagen I and IV. Potential strategies for the prevention of nephrotoxicity are discussed. 
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