Clinical applications of antineutrophil cytoplasmic antibody testing
Purpose of review: Antineutrophil cytoplasmic antibodies are closely associated with Wegener granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome and have contributed to new pathogenetic concepts and improved nomenclature of systemic vasculitides (antineutrophil cytoplasmic antibody-...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2004
|
| In: |
Current opinion in rheumatology
Year: 2004, Jahrgang: 16, Heft: 1, Pages: 9-17 |
| ISSN: | 1531-6963 |
| DOI: | 10.1097/00002281-200401000-00004 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/00002281-200401000-00004 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/co-rheumatology/fulltext/2004/01000/clinical_applications_of_antineutrophil.4.aspx 
|
| Verfasserangaben: | Wilhelm H. Schmitt, Fokko J. van der Woude |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 180572407X | ||
| 003 | DE-627 | ||
| 005 | 20230428181832.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220602s2004 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1097/00002281-200401000-00004 |2 doi | |
| 035 | |a (DE-627)180572407X | ||
| 035 | |a (DE-599)KXP180572407X | ||
| 035 | |a (OCoLC)1341461095 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schmitt, Wilhelm |d 1960- |e VerfasserIn |0 (DE-588)1048670813 |0 (DE-627)780888235 |0 (DE-576)402969502 |4 aut | |
| 245 | 1 | 0 | |a Clinical applications of antineutrophil cytoplasmic antibody testing |c Wilhelm H. Schmitt, Fokko J. van der Woude |
| 264 | 1 | |c 2004 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 02.06.2022 | ||
| 520 | |a Purpose of review: Antineutrophil cytoplasmic antibodies are closely associated with Wegener granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome and have contributed to new pathogenetic concepts and improved nomenclature of systemic vasculitides (antineutrophil cytoplasmic antibody-associated vasculitides). However, the application of antineutrophil cytoplasmic antibody testing as a clinical diagnostic tool is still regarded as controversial. This review summarizes the most recent developments in the field, identifies areas of uncertainty, and gives practical guidelines. Recent findings: The problems of antineutrophil cytoplasmic antibody testing include the diversity of antineutrophil cytoplasmic antibody target antigens, assay standardization and performance, the application of antineutrophil cytoplasmic antibody testing in a clinical setting with a low pretest probability, and, finally, the widespread assumption that antineutrophil cytoplasmic antibody titers alone may closely reflect disease activity and therefore may be used to guide therapy. Summary: Recent findings demonstrate that the combined use of indirect immunofluorescence tests and solid phase assays to detect antineutrophil cytoplasmic antibody directed against myeloperoxidase and proteinase 3 can minimize the occurrence of false-positive antineutrophil cytoplasmic antibody results. Furthermore, the yield of antineutrophil cytoplasmic antibody testing can be improved by the use of a well-standardized test, adherence to published guidelines, and restricting the use of the tests to clinical situations with a rather high pretest probability for antineutrophil cytoplasmic antibody-associated vasculitides. However, treatment decisions should be based on the clinical presentation of the patient and histologic findings and not on the results of antineutrophil cytoplasmic antibody testing alone. | ||
| 700 | 1 | |a Woude, Fokko J. van der |d 1953-2006 |e VerfasserIn |0 (DE-588)173440835 |0 (DE-627)698355067 |0 (DE-576)134286820 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Current opinion in rheumatology |d Philadelphia, Pa. : Lippincott Williams & Wilkins, 1989 |g 16(2004), 1, Seite 9-17 |h Online-Ressource |w (DE-627)324455755 |w (DE-600)2026973-0 |w (DE-576)093981090 |x 1531-6963 |7 nnas |a Clinical applications of antineutrophil cytoplasmic antibody testing |
| 773 | 1 | 8 | |g volume:16 |g year:2004 |g number:1 |g pages:9-17 |g extent:9 |a Clinical applications of antineutrophil cytoplasmic antibody testing |
| 856 | 4 | 0 | |u https://doi.org/10.1097/00002281-200401000-00004 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://journals.lww.com/co-rheumatology/fulltext/2004/01000/clinical_applications_of_antineutrophil.4.aspx |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220602 | ||
| 993 | |a Article | ||
| 994 | |a 2004 | ||
| 998 | |g 173440835 |a Woude, Fokko J. van der |m 173440835:Woude, Fokko J. van der |d 60000 |d 61400 |e 60000PW173440835 |e 61400PW173440835 |k 0/60000/ |k 1/60000/61400/ |p 2 |y j | ||
| 998 | |g 1048670813 |a Schmitt, Wilhelm |m 1048670813:Schmitt, Wilhelm |d 60000 |d 61400 |e 60000PS1048670813 |e 61400PS1048670813 |k 0/60000/ |k 1/60000/61400/ |p 1 |x j | ||
| 999 | |a KXP-PPN180572407X |e 4142374109 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Clinical applications of antineutrophil cytoplasmic antibody testing","title_sort":"Clinical applications of antineutrophil cytoplasmic antibody testing"}],"person":[{"family":"Schmitt","given":"Wilhelm","roleDisplay":"VerfasserIn","display":"Schmitt, Wilhelm","role":"aut"},{"family":"Woude","given":"Fokko J. van der","roleDisplay":"VerfasserIn","display":"Woude, Fokko J. van der","role":"aut"}],"language":["eng"],"recId":"180572407X","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 02.06.2022"],"id":{"eki":["180572407X"],"doi":["10.1097/00002281-200401000-00004"]},"origin":[{"dateIssuedDisp":"2004","dateIssuedKey":"2004"}],"name":{"displayForm":["Wilhelm H. Schmitt, Fokko J. van der Woude"]},"relHost":[{"origin":[{"publisherPlace":"Philadelphia, Pa. ; [Erscheinungsort nicht ermittelbar]","dateIssuedKey":"1989","publisher":"Lippincott Williams & Wilkins ; Ovid","dateIssuedDisp":"1989-"}],"id":{"zdb":["2026973-0"],"eki":["324455755"],"issn":["1531-6963"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Current opinion in rheumatology","title":"Current opinion in rheumatology"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Clinical applications of antineutrophil cytoplasmic antibody testingCurrent opinion in rheumatology","note":["Gesehen am 24.01.05"],"language":["eng"],"recId":"324455755","pubHistory":["1.1989 -"],"part":{"year":"2004","pages":"9-17","issue":"1","volume":"16","text":"16(2004), 1, Seite 9-17","extent":"9"}}],"physDesc":[{"extent":"9 S."}]} | ||
| SRT | |a SCHMITTWILCLINICALAP2004 | ||