Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors

Purpose: The underlying molecular mechanisms of thymic epithelial malignancies (TEMs) are poorly understood. Consequently, there is a lack of efficacious targeted therapies and patient prognosis remains dismal, particularly for advanced TEMs. We sought to investigate protumorigenic mechanism relevan...

Full description

Bibliographic Details

Main Authors:	Breinig, Marco (Author) , Mayer, Philipp (Author) , Harjung, Andreas (Author) , Goeppert, Benjamin (Author) , Malz, Mona (Author) , Penzel, Roland (Author) , Neumann, Olaf (Author) , Hartmann, Arndt (Author) , Dienemann, Hendrik (Author) , Giaccone, Giuseppe (Author) , Schirmacher, Peter (Author) , Kern, Michael A. (Author) , Chiosis, Gabriela (Author) , Rieker, Ralf Joachim (Author)
Format:	Article (Journal)
Language:	English
Published:	April 14 2011
In:	Clinical cancer research Year: 2011, Volume: 17, Issue: 8, Pages: 2237-2249
ISSN:	1557-3265
DOI:	10.1158/1078-0432.CCR-10-1689
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/1078-0432.CCR-10-1689
Author Notes:	Marco Breinig, Philipp Mayer, Andreas Harjung, Benjamin Goeppert, Mona Malz, Roland Penzel, Olaf Neumann, Arndt Hartmann, Hendrik Dienemann, Giuseppe Giaccone, Peter Schirmacher, Michael André Kern, Gabriela Chiosis, and Ralf Joachim Rieker