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The rat Pkd2 protein assumes distinct subcellular distributions in different organs

Mutations in thePKD2 gene account for ∼15% of all cases of autosomal-dominant polycystic kidney disease. In the present study the cellular distribution of the Pkd2 protein was investigated by immunohistochemistry in different rat organs. Although the Pkd2 protein showed a widespread expression, a st...

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Hauptverfasser: Obermüller, Nicholas (VerfasserIn) , Gallagher, Anna Rachel (VerfasserIn) , Cai, Yiqiang (VerfasserIn) , Gaßler, Nikolaus (VerfasserIn) , Gretz, Norbert (VerfasserIn) , Somlo, Stefan (VerfasserIn) , Witzgall, Ralph (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [December 1999]
In: American journal of physiology. Renal physiology
Year: 1999, Jahrgang: 277, Heft: 6, Pages: F914-F925
ISSN:1522-1466
DOI:10.1152/ajprenal.1999.277.6.F914
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1152/ajprenal.1999.277.6.F914
Verlag, lizenzpflichtig, Volltext: https://journals.physiology.org/doi/full/10.1152/ajprenal.1999.277.6.F914
Volltext
Verfasserangaben:Nicholas Obermüller, A. Rachel Gallagher, Yiqiang Cai, Nikolaus Gassler, Norbert Gretz, Stefan Somlo, and Ralph Witzgall

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520 |a Mutations in thePKD2 gene account for ∼15% of all cases of autosomal-dominant polycystic kidney disease. In the present study the cellular distribution of the Pkd2 protein was investigated by immunohistochemistry in different rat organs. Although the Pkd2 protein showed a widespread expression, a strikingly different distribution of the protein was observed between individual organs. Whereas in renal distal tubules and in striated ducts of salivary glands a basal-to-basolateral distribution of Pkd2 was found, a punctate cytoplasmic location was detected in the adrenal gland, ovary, cornea, and smooth muscle cells of blood vessels. Interestingly, in the adrenal gland and ovary, the rat Pkd2 protein was more heavilyN-glycosylated than in the kidney and salivary gland. These results suggest that Pkd2 accomplishes its functions by interacting with proteins located in different cellular compartments. The extrarenal expression pattern of the Pkd2 protein hints at other candidate sites of disease manifestations in patients carryingPKD2 mutations. 
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