ADCK2 knockdown affects the migration of melanoma cells via MYL6
Background: ADCK2 is a member of the AarF domain-containing kinase family, which consists of five members, and has been shown to play a role in CoQ metabolism. However, ADCKs have also been connected to cancer cell survival, proliferation and motility. In this study, we investigated the role of ADCK...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
20 February 2022
|
| In: |
Cancers
Year: 2022, Jahrgang: 14, Heft: 4, Pages: 1-18 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers14041071 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers14041071 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/14/4/1071 
|
| Verfasserangaben: | Marlene Vierthaler, Qian Sun, Yiman Wang, Tamara Steinfass, Juliane Poelchen, Thomas Hielscher, Daniel Novak, Viktor Umansky, Jochen Utikal |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1806534398 | ||
| 003 | DE-627 | ||
| 005 | 20230522161647.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220609s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/cancers14041071 |2 doi | |
| 035 | |a (DE-627)1806534398 | ||
| 035 | |a (DE-599)KXP1806534398 | ||
| 035 | |a (OCoLC)1341461293 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Vierthaler, Marlene |d 1991- |e VerfasserIn |0 (DE-588)1253024111 |0 (DE-627)1794873279 |4 aut | |
| 245 | 1 | 0 | |a ADCK2 knockdown affects the migration of melanoma cells via MYL6 |c Marlene Vierthaler, Qian Sun, Yiman Wang, Tamara Steinfass, Juliane Poelchen, Thomas Hielscher, Daniel Novak, Viktor Umansky, Jochen Utikal |
| 246 | 3 | 3 | |a ADCK two knockdown affects the migration of melanoma cells via MYL six |
| 246 | 3 | 3 | |a ADCK 2 knockdown affects the migration of melanoma cells via MYL 6 |
| 264 | 1 | |c 20 February 2022 | |
| 300 | |a 18 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a This article belongs to the Special Issue Epidemiology and Biological Features of Melanoma | ||
| 500 | |a Gesehen am 09.06.2022 | ||
| 520 | |a Background: ADCK2 is a member of the AarF domain-containing kinase family, which consists of five members, and has been shown to play a role in CoQ metabolism. However, ADCKs have also been connected to cancer cell survival, proliferation and motility. In this study, we investigated the role of ADCK2 in melanoma. Methods: The effect of ADCK2 on melanoma cell motility was evaluated by a scratch assay and a transwell invasion assay upon siRNA-mediated knockdown or stable overexpression of ADCK2. Results: We found that high levels of intratumoral ADCK2 and MYL6 are associated with a higher survival rate in melanoma patients. Knocking down ADCK2 resulted in enhanced cell migration of melanoma cells. Moreover, ADCK2-knockdown cells adopted a more dedifferentiated phenotype. A gene expression array revealed that the expression of ADCK2 correlated with the expressions of MYL6 and RAB2A. Knocking down MYL6 in ADCK2-overexpressing cells could abrogate the effect of ADCK2 overexpression and thus confirm the functional connection between ADCK2 and MYL6. Conclusion: ADCK2 affects melanoma cell motility, most probably via MYL6. Our results allow the conclusion that ADCK2 could act as a tumor suppressor in melanoma. | ||
| 650 | 4 | |a ADCK2 | |
| 650 | 4 | |a cancer | |
| 650 | 4 | |a melanoma | |
| 650 | 4 | |a motility | |
| 650 | 4 | |a MYL6 | |
| 700 | 1 | |a Sun, Qian |e VerfasserIn |0 (DE-588)1244231878 |0 (DE-627)1775296148 |4 aut | |
| 700 | 1 | |a Wang, Yiman |d 1994- |e VerfasserIn |0 (DE-588)1290221146 |0 (DE-627)1845935403 |4 aut | |
| 700 | 1 | |a Steinfass, Tamara |d 1992- |e VerfasserIn |0 (DE-588)1272471241 |0 (DE-627)182159634X |4 aut | |
| 700 | 1 | |a Poelchen, Juliane |d 1993- |e VerfasserIn |0 (DE-588)1237827760 |0 (DE-627)1764891562 |4 aut | |
| 700 | 1 | |a Hielscher, Thomas |e VerfasserIn |0 (DE-588)1159594791 |0 (DE-627)1022977768 |0 (DE-576)50506068X |4 aut | |
| 700 | 1 | |a Novak, Daniel |d 1978- |e VerfasserIn |0 (DE-588)1026462975 |0 (DE-627)726763764 |0 (DE-576)371815533 |4 aut | |
| 700 | 1 | |a Umansky, Viktor |d 1955- |e VerfasserIn |0 (DE-588)102885756X |0 (DE-627)731733207 |0 (DE-576)376300078 |4 aut | |
| 700 | 1 | |a Utikal, Jochen |d 1974- |e VerfasserIn |0 (DE-588)1026463750 |0 (DE-627)726765015 |0 (DE-576)371816580 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancers |d Basel : MDPI, 2009 |g 14(2022), 4, Artikel-ID 1071, Seite 1-18 |h Online-Ressource |w (DE-627)614095670 |w (DE-600)2527080-1 |w (DE-576)313958548 |x 2072-6694 |7 nnas |a ADCK2 knockdown affects the migration of melanoma cells via MYL6 |
| 773 | 1 | 8 | |g volume:14 |g year:2022 |g number:4 |g elocationid:1071 |g pages:1-18 |g extent:18 |a ADCK2 knockdown affects the migration of melanoma cells via MYL6 |
| 856 | 4 | 0 | |u https://doi.org/10.3390/cancers14041071 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2072-6694/14/4/1071 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220609 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1026463750 |a Utikal, Jochen |m 1026463750:Utikal, Jochen |d 60000 |e 60000PU1026463750 |k 0/60000/ |p 9 |y j | ||
| 998 | |g 102885756X |a Umansky, Viktor |m 102885756X:Umansky, Viktor |d 60000 |d 61900 |d 140000 |e 60000PU102885756X |e 61900PU102885756X |e 140000PU102885756X |k 0/60000/ |k 1/60000/61900/ |k 0/140000/ |p 8 | ||
| 998 | |g 1026462975 |a Novak, Daniel |m 1026462975:Novak, Daniel |d 60000 |d 61900 |e 60000PN1026462975 |e 61900PN1026462975 |k 0/60000/ |k 1/60000/61900/ |p 7 | ||
| 998 | |g 1237827760 |a Poelchen, Juliane |m 1237827760:Poelchen, Juliane |d 140000 |d 60000 |d 61900 |e 140000PP1237827760 |e 60000PP1237827760 |e 61900PP1237827760 |k 0/140000/ |k 0/60000/ |k 1/60000/61900/ |p 5 | ||
| 998 | |g 1272471241 |a Steinfass, Tamara |m 1272471241:Steinfass, Tamara |d 60000 |d 61900 |e 60000PS1272471241 |e 61900PS1272471241 |k 0/60000/ |k 1/60000/61900/ |p 4 | ||
| 998 | |g 1290221146 |a Wang, Yiman |m 1290221146:Wang, Yiman |d 60000 |e 60000PW1290221146 |k 0/60000/ |p 3 | ||
| 998 | |g 1244231878 |a Sun, Qian |m 1244231878:Sun, Qian |d 60000 |d 61900 |e 60000PS1244231878 |e 61900PS1244231878 |k 0/60000/ |k 1/60000/61900/ |p 2 | ||
| 998 | |g 102885756X |a Umansky, Viktor |m 102885756X:Umansky, Viktor |d 140000 |e 140000PU102885756X |k 0/140000/ |p 8 | ||
| 998 | |g 1159594791 |a Hielscher, Thomas |m 1159594791:Hielscher, Thomas |d 140000 |e 140000PH1159594791 |k 0/140000/ |p 6 | ||
| 998 | |g 1272471241 |a Steinfass, Tamara |m 1272471241:Steinfass, Tamara |d 140000 |e 140000PS1272471241 |k 0/140000/ |p 4 | ||
| 998 | |g 1253024111 |a Vierthaler, Marlene |m 1253024111:Vierthaler, Marlene |p 1 |x j | ||
| 999 | |a KXP-PPN1806534398 |e 4146467926 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"title":[{"title_sort":"Cancers","title":"Cancers"}],"physDesc":[{"extent":"Online-Ressource"}],"part":{"pages":"1-18","year":"2022","issue":"4","extent":"18","text":"14(2022), 4, Artikel-ID 1071, Seite 1-18","volume":"14"},"language":["eng"],"pubHistory":["1.2009 -"],"note":["Gesehen am 27.05.2020"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"614095670","id":{"zdb":["2527080-1"],"eki":["614095670"],"issn":["2072-6694"]},"origin":[{"publisher":"MDPI","dateIssuedKey":"2009","publisherPlace":"Basel","dateIssuedDisp":"2009-"}],"name":{"displayForm":["Molecular Diversity Preservation International (MDPI)"]},"disp":"ADCK2 knockdown affects the migration of melanoma cells via MYL6Cancers"}],"physDesc":[{"extent":"18 S."}],"title":[{"title":"ADCK2 knockdown affects the migration of melanoma cells via MYL6","title_sort":"ADCK2 knockdown affects the migration of melanoma cells via MYL6"}],"recId":"1806534398","id":{"doi":["10.3390/cancers14041071"],"eki":["1806534398"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["Marlene Vierthaler, Qian Sun, Yiman Wang, Tamara Steinfass, Juliane Poelchen, Thomas Hielscher, Daniel Novak, Viktor Umansky, Jochen Utikal"]},"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"20 February 2022"}],"note":["This article belongs to the Special Issue Epidemiology and Biological Features of Melanoma","Gesehen am 09.06.2022"],"titleAlt":[{"title":"ADCK two knockdown affects the migration of melanoma cells via MYL six"},{"title":"ADCK 2 knockdown affects the migration of melanoma cells via MYL 6"}],"language":["eng"],"person":[{"given":"Marlene","family":"Vierthaler","role":"aut","display":"Vierthaler, Marlene"},{"family":"Sun","role":"aut","display":"Sun, Qian","given":"Qian"},{"given":"Yiman","family":"Wang","role":"aut","display":"Wang, Yiman"},{"family":"Steinfass","role":"aut","display":"Steinfass, Tamara","given":"Tamara"},{"given":"Juliane","display":"Poelchen, Juliane","role":"aut","family":"Poelchen"},{"given":"Thomas","display":"Hielscher, Thomas","role":"aut","family":"Hielscher"},{"given":"Daniel","role":"aut","family":"Novak","display":"Novak, Daniel"},{"given":"Viktor","role":"aut","family":"Umansky","display":"Umansky, Viktor"},{"display":"Utikal, Jochen","role":"aut","family":"Utikal","given":"Jochen"}]} | ||
| SRT | |a VIERTHALERADCK2KNOCK2020 | ||