Pharmacokinetics of 5-Aminofluorescein-Albumin, a novel fluorescence marker of brain tumors during surgery
In a phase I/II study, the new fluorescence marker 5-aminofluorescein covalently bound to human serum albumin (AFL-HSA) was intravenously administered to 10 patients with brain tumor 1 to 4 days before surgery, and AFL-HSA kinetics were determined to assess the optimum timing of dye administration....
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2011
|
| In: |
Journal of clinical pharmacology
Year: 2011, Jahrgang: 51, Heft: 5, Pages: 672-678 |
| ISSN: | 1552-4604 |
| DOI: | 10.1177/0091270010372626 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1177/0091270010372626 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1177/0091270010372626 
|
| Verfasserangaben: | Reinhard Ding, Eva Frei, Mahmoudreza Fardanesh, Hans-Hermann Schrenk, Paul Kremer, and Walter E. Haefeli |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1806848767 | ||
| 003 | DE-627 | ||
| 005 | 20230427160804.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220613s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/0091270010372626 |2 doi | |
| 035 | |a (DE-627)1806848767 | ||
| 035 | |a (DE-599)KXP1806848767 | ||
| 035 | |a (OCoLC)1341461315 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Ding, Reinhard |e VerfasserIn |0 (DE-588)1233757008 |0 (DE-627)1758158425 |4 aut | |
| 245 | 1 | 0 | |a Pharmacokinetics of 5-Aminofluorescein-Albumin, a novel fluorescence marker of brain tumors during surgery |c Reinhard Ding, Eva Frei, Mahmoudreza Fardanesh, Hans-Hermann Schrenk, Paul Kremer, and Walter E. Haefeli |
| 264 | 1 | |c 2011 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Elektronische Reproduktion der Druck-Ausgabe | ||
| 500 | |a Gesehen am 13.06.2022 | ||
| 520 | |a In a phase I/II study, the new fluorescence marker 5-aminofluorescein covalently bound to human serum albumin (AFL-HSA) was intravenously administered to 10 patients with brain tumor 1 to 4 days before surgery, and AFL-HSA kinetics were determined to assess the optimum timing of dye administration. AFL-HSA was determined in serum and brain tissue by size exclusion chromatography with fluorescence detection. AFL-HSA disposition was quite similar to albumin kinetics with small volumes of distribution (volume of central compartment [Vc] = 2.4 L; volume of distribution [Vdβ] = 6.8 L; volume at steady state [Vss] = 5.9 L), a low clearance (mean Cl = 16.85 mL/h), and a long elimination half-life (mean T½β = 307 hours). Predicted peak concentrations in the peripheral compartment occurred at 80.9 hours, the time point of optimal fluorescence intensity observed in brain tumors during surgery. | ||
| 650 | 4 | |a 5-aminofluorescein | |
| 650 | 4 | |a brain neoplasms | |
| 650 | 4 | |a human serum albumin | |
| 650 | 4 | |a pharmacokinetics | |
| 700 | 1 | |a Frei, Eva |d 1950- |e VerfasserIn |0 (DE-588)112546450X |0 (DE-627)880025433 |0 (DE-576)483423068 |4 aut | |
| 700 | 1 | |a Fardanesh, Mahmoudreza |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schrenk, Hans-Hermann |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kremer, Paul |e VerfasserIn |4 aut | |
| 700 | 1 | |a Haefeli, Walter E. |d 1958- |e VerfasserIn |0 (DE-588)124572359 |0 (DE-627)656806141 |0 (DE-576)340514221 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of clinical pharmacology |d Hoboken, NJ : Wiley, 1974 |g 51(2011), 5, Seite 672-678 |h Online-Ressource |w (DE-627)320484599 |w (DE-600)2010253-7 |w (DE-576)094752567 |x 1552-4604 |7 nnas |a Pharmacokinetics of 5-Aminofluorescein-Albumin, a novel fluorescence marker of brain tumors during surgery |
| 773 | 1 | 8 | |g volume:51 |g year:2011 |g number:5 |g pages:672-678 |g extent:7 |a Pharmacokinetics of 5-Aminofluorescein-Albumin, a novel fluorescence marker of brain tumors during surgery |
| 856 | 4 | 0 | |u https://doi.org/10.1177/0091270010372626 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1177/0091270010372626 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220613 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 124572359 |a Haefeli, Walter E. |m 124572359:Haefeli, Walter E. |d 910000 |d 910100 |e 910000PH124572359 |e 910100PH124572359 |k 0/910000/ |k 1/910000/910100/ |p 6 |y j | ||
| 998 | |g 112546450X |a Frei, Eva |m 112546450X:Frei, Eva |d 140000 |e 140000PF112546450X |k 0/140000/ |p 2 | ||
| 999 | |a KXP-PPN1806848767 |e 4148862636 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"person":[{"display":"Ding, Reinhard","given":"Reinhard","role":"aut","roleDisplay":"VerfasserIn","family":"Ding"},{"family":"Frei","display":"Frei, Eva","given":"Eva","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","given":"Mahmoudreza","display":"Fardanesh, Mahmoudreza","family":"Fardanesh"},{"given":"Hans-Hermann","role":"aut","roleDisplay":"VerfasserIn","display":"Schrenk, Hans-Hermann","family":"Schrenk"},{"family":"Kremer","role":"aut","roleDisplay":"VerfasserIn","given":"Paul","display":"Kremer, Paul"},{"given":"Walter E.","roleDisplay":"VerfasserIn","role":"aut","display":"Haefeli, Walter E.","family":"Haefeli"}],"relHost":[{"recId":"320484599","part":{"pages":"672-678","extent":"7","year":"2011","text":"51(2011), 5, Seite 672-678","issue":"5","volume":"51"},"note":["Gesehen am 18.11.24"],"pubHistory":["Volume 14, issue 1 (1974)-"],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"zdb":["2010253-7"],"eki":["320484599"],"issn":["1552-4604"],"doi":["10.1002/(ISSN)1552-4604"]},"title":[{"title":"Journal of clinical pharmacology","title_sort":"Journal of clinical pharmacology"}],"name":{"displayForm":["publ. in association with the American College of Clinical Pharmacology"]},"origin":[{"publisher":"Wiley ; Sage","dateIssuedDisp":"1974-","dateIssuedKey":"1974","publisherPlace":"Hoboken, NJ ; Thousand Oaks [u.a.]"}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Pharmacokinetics of 5-Aminofluorescein-Albumin, a novel fluorescence marker of brain tumors during surgeryJournal of clinical pharmacology","language":["eng"]}],"id":{"eki":["1806848767"],"doi":["10.1177/0091270010372626"]},"name":{"displayForm":["Reinhard Ding, Eva Frei, Mahmoudreza Fardanesh, Hans-Hermann Schrenk, Paul Kremer, and Walter E. Haefeli"]},"origin":[{"dateIssuedDisp":"2011","dateIssuedKey":"2011"}],"physDesc":[{"extent":"7 S."}],"title":[{"title_sort":"Pharmacokinetics of 5-Aminofluorescein-Albumin, a novel fluorescence marker of brain tumors during surgery","title":"Pharmacokinetics of 5-Aminofluorescein-Albumin, a novel fluorescence marker of brain tumors during surgery"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1806848767","note":["Elektronische Reproduktion der Druck-Ausgabe","Gesehen am 13.06.2022"]} | ||
| SRT | |a DINGREINHAPHARMACOKI2011 | ||