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Pharmacokinetics of 5-Aminofluorescein-Albumin, a novel fluorescence marker of brain tumors during surgery

In a phase I/II study, the new fluorescence marker 5-aminofluorescein covalently bound to human serum albumin (AFL-HSA) was intravenously administered to 10 patients with brain tumor 1 to 4 days before surgery, and AFL-HSA kinetics were determined to assess the optimum timing of dye administration....

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Bibliographische Detailangaben
Hauptverfasser: Ding, Reinhard (VerfasserIn) , Frei, Eva (VerfasserIn) , Fardanesh, Mahmoudreza (VerfasserIn) , Schrenk, Hans-Hermann (VerfasserIn) , Kremer, Paul (VerfasserIn) , Haefeli, Walter E. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2011
In: Journal of clinical pharmacology
Year: 2011, Jahrgang: 51, Heft: 5, Pages: 672-678
ISSN:1552-4604
DOI:10.1177/0091270010372626
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1177/0091270010372626
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1177/0091270010372626
Volltext
Verfasserangaben:Reinhard Ding, Eva Frei, Mahmoudreza Fardanesh, Hans-Hermann Schrenk, Paul Kremer, and Walter E. Haefeli
Beschreibung
Zusammenfassung:In a phase I/II study, the new fluorescence marker 5-aminofluorescein covalently bound to human serum albumin (AFL-HSA) was intravenously administered to 10 patients with brain tumor 1 to 4 days before surgery, and AFL-HSA kinetics were determined to assess the optimum timing of dye administration. AFL-HSA was determined in serum and brain tissue by size exclusion chromatography with fluorescence detection. AFL-HSA disposition was quite similar to albumin kinetics with small volumes of distribution (volume of central compartment [Vc] = 2.4 L; volume of distribution [Vdβ] = 6.8 L; volume at steady state [Vss] = 5.9 L), a low clearance (mean Cl = 16.85 mL/h), and a long elimination half-life (mean T½β = 307 hours). Predicted peak concentrations in the peripheral compartment occurred at 80.9 hours, the time point of optimal fluorescence intensity observed in brain tumors during surgery.
Beschreibung:Elektronische Reproduktion der Druck-Ausgabe
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Beschreibung:Online Resource
ISSN:1552-4604
DOI:10.1177/0091270010372626

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