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Prevalence of antineutrophil cytoplasmic autoantibodies in patients with tuberculosis

OBJECTIVE: To determine the prevalence of antineutrophil cytoplasmic autoantibodies (ANCA) in sera of patients with tuberculosis compared with healthy control subjects and a group of patients with atopic asthma. METHODS: The presence of ANCA was examined in patients with tuberculosis, and in asthmat...

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Main Authors: Flores-Suárez, Luis Felipe (Author) , Cabiedes, J. (Author) , Villa, A. R. (Author) , Woude, Fokko J. van der (Author) , Alcocer-Varela, J. (Author)
Format: Article (Journal)
Language:English
Published: 2003
In: Rheumatology
Year: 2003, Volume: 42, Issue: 2, Pages: 223-229
ISSN:1462-0332
DOI:10.1093/rheumatology/keg066
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/rheumatology/keg066
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Author Notes:L.F. Flores-Suárez, J. Cabiedes, A.R. Villa, F.J. van der Woude and J. Alcocer-Varela

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245 1 0 |a Prevalence of antineutrophil cytoplasmic autoantibodies in patients with tuberculosis  |c L.F. Flores-Suárez, J. Cabiedes, A.R. Villa, F.J. van der Woude and J. Alcocer-Varela 
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520 |a OBJECTIVE: To determine the prevalence of antineutrophil cytoplasmic autoantibodies (ANCA) in sera of patients with tuberculosis compared with healthy control subjects and a group of patients with atopic asthma. METHODS: The presence of ANCA was examined in patients with tuberculosis, and in asthmatic patients and healthy subjects as control groups, by means of indirect immunofluorescence (IIF) and enzyme-linked immunosorbent assay (ELISA) to detect anti-proteinase 3 (PR3-ANCA) and antimyeloperoxidase (MPO-ANCA) antibodies. RESULTS: ANCA were present in 20 (44.4%) of 45 tuberculosis patients by IIF (16 c-ANCA, four p-ANCA) and in 18 (40%) patients by ELISA (15 PR3-ANCA, three MPO-ANCA). High odds ratios for ANCA positivity were observed for tuberculosis patients when compared with both control groups. ANCA results were not related to the category of tuberculosis, stage of disease, presence of concomitant diseases or pharmacotherapy. CONCLUSIONS: As many clinical similarities between tuberculosis and Wegener's granulomatosis exist, we propose that a positive ANCA test in patients living in countries with a high prevalence of tuberculosis must be carefully interpreted as indicative of systemic vasculitis, especially when no signs of extrapulmonary involvement occur. 
650 4 |a Adult 
650 4 |a Antibodies, Antineutrophil Cytoplasmic 
650 4 |a Asthma 
650 4 |a Enzyme-Linked Immunosorbent Assay 
650 4 |a Female 
650 4 |a Fluorescent Antibody Technique, Indirect 
650 4 |a Humans 
650 4 |a Male 
650 4 |a Middle Aged 
650 4 |a Myeloblastin 
650 4 |a Odds Ratio 
650 4 |a Peroxidase 
650 4 |a Serine Endopeptidases 
650 4 |a Tuberculosis, Pulmonary 
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700 1 |a Villa, A. R.  |e VerfasserIn  |4 aut 
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