Liver regeneration in FGF-2-deficient mice: VEGF acts as potential functional substitute for FGF-2
Background/Aims: The angiogenic properties, its role in mesoderm differentiation and cell culture studies implicate an important role of fibroblast growth factor (FGF-2) in liver regeneration. The aim of the study was to evaluate this role in a FGF-2 knockout mouse model. Methods: Liver regeneration...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 April 2004
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| In: |
Liver international
Year: 2004, Jahrgang: 24, Heft: 2, Pages: 161-168 |
| ISSN: | 1478-3231 |
| DOI: | 10.1111/j.1478-3231.2004.0896.x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1478-3231.2004.0896.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1478-3231.2004.0896.x 
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| Verfasserangaben: | Jörg Sturm, Michael Keese, Honyue Zhang, Roderich Bönninghoff, Richard Magdeburg, Peter Vajkoczy, Rosanna Dono, Rolf Zeller, Norbert Gretz |
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| 245 | 1 | 0 | |a Liver regeneration in FGF-2-deficient mice |b VEGF acts as potential functional substitute for FGF-2 |c Jörg Sturm, Michael Keese, Honyue Zhang, Roderich Bönninghoff, Richard Magdeburg, Peter Vajkoczy, Rosanna Dono, Rolf Zeller, Norbert Gretz |
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| 520 | |a Background/Aims: The angiogenic properties, its role in mesoderm differentiation and cell culture studies implicate an important role of fibroblast growth factor (FGF-2) in liver regeneration. The aim of the study was to evaluate this role in a FGF-2 knockout mouse model. Methods: Liver regeneration after left hemihepatectomy (partial hepatectomy, PH) was evaluated in homozygous FGF-2 deficient (−/−) mice (male C57BL/6J) and their FGF-2 competent (+/+) littermates (controls) (day 0-10). Results: FGF-2-(−/−) mice displayed normal dynamics in liver regeneration. FGF-2 protein was overexpressed 4 days post PH in controls. BrdU incorporation showed a biphasic pattern in FGF-2-(−/−) mice, whereas it decreased continuously after one peak (day 2) in controls. In FGF-2-(−/−) livers hepatic growth factor mRNA post PH was 1 day longer decreased and markedly less elevated thereafter compared with control. Vascular endothelial growth factor (VEGF) mRNA levels were clearly increased in FGF-2-(−/−) mice pre- and postoperatively in contrast to controls. VEGF protein levels in livers of FGF-2-(−/−) mice were elevated preoperatively, but similar in both groups after PH. With SU5416, a VEGF-receptor inhibitor, liver regeneration in FGF-2-(−/−) mice was reduced significantly, whereas it remained unchanged in controls. Conclusions: Liver regeneration dynamics in FGF-2-(−/−) mice were comparable with controls, potentially due to a functional substitution of FGF-2 by VEGF. | ||
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