MicroRNA-138 controls hippocampal interneuron function and short-term memory in mice
The proper development and function of neuronal circuits rely on a tightly regulated balance between excitatory and inhibitory (E/I) synaptic transmission, and disrupting this balance can cause neurodevelopmental disorders, for example, schizophrenia. MicroRNA-dependent gene regulation in pyramidal...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 March 2022
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| In: |
eLife
Year: 2022, Jahrgang: 11, Pages: 1-24 |
| ISSN: | 2050-084X |
| DOI: | 10.7554/eLife.74056 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.7554/eLife.74056
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| Verfasserangaben: | Reetu Daswani, Carlotta Gilardi, Michael Soutschek, Prakruti Nanda, Kerstin Weiss, Silvia Bicker, Roberto Fiore, Christoph Dieterich, Pierre-Luc Germain, Jochen Winterer, Gerhard Schratt |
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| 245 | 1 | 0 | |a MicroRNA-138 controls hippocampal interneuron function and short-term memory in mice |c Reetu Daswani, Carlotta Gilardi, Michael Soutschek, Prakruti Nanda, Kerstin Weiss, Silvia Bicker, Roberto Fiore, Christoph Dieterich, Pierre-Luc Germain, Jochen Winterer, Gerhard Schratt |
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| 520 | |a The proper development and function of neuronal circuits rely on a tightly regulated balance between excitatory and inhibitory (E/I) synaptic transmission, and disrupting this balance can cause neurodevelopmental disorders, for example, schizophrenia. MicroRNA-dependent gene regulation in pyramidal neurons is important for excitatory synaptic function and cognition, but its role in inhibitory interneurons is poorly understood. Here, we identify miR138-5p as a regulator of short-term memory and inhibitory synaptic transmission in the mouse hippocampus. Sponge-mediated miR138-5p inactivation specifically in mouse parvalbumin (PV)-expressing interneurons impairs spatial recognition memory and enhances GABAergic synaptic input onto pyramidal neurons. Cellular and behavioral phenotypes associated with miR138-5p inactivation are paralleled by an upregulation of the schizophrenia (SCZ)-associated Erbb4, which we validated as a direct miR138-5p target gene. Our findings suggest that miR138-5p is a critical regulator of PV interneuron function in mice, with implications for cognition and SCZ. More generally, they provide evidence that microRNAs orchestrate neural circuit development by fine-tuning both excitatory and inhibitory synaptic transmission. | ||
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| 700 | 1 | |a Nanda, Prakruti |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weiss, Kerstin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bicker, Silvia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fiore, Roberto |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Winterer, Jochen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schratt, Gerhard |e VerfasserIn |4 aut | |
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