PDGF-BB induces expression of LTBP-1 but not TGF-β1 in a rat cirrhotic fat storing cell line

TGF-β, a profibrogenic cytokine is predominantly secreted as a latent molecule complexed with one of the latent TGF-β binding proteins (LTBP). Due to the proposed functions of LTBP-1 and -3 in regulating TGF-β-bioavailability and -activity, we investigated the effects of PDGF-BB and TGF-β1 on their...

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Main Authors: Westhoff, Jens (Author) , Sawitza, Iris (Author) , Keski-Oja, Jorma (Author) , Gressner, Axel M. (Author) , Breitkopf-Heinlein, Katja (Author)
Format: Article (Journal)
Language:English
Published: 2003
In: Growth factors
Year: 2003, Volume: 21, Issue: 3/4, Pages: 121-130
ISSN:1029-2292
DOI:10.1080/08977190310001637224
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/08977190310001637224
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Author Notes:Jens H. Westhoff, Iris Sawitza, Jorma Keski-Oja, Axel M. Gressner & Katja Breitkopf
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Characterization of intracellular pathways leading to coinduction of thrombospondin-1 and TGF-β1 expression in rat hepatic stellate cells by Breitkopf-Heinlein, Katja (Author) , Sawitza, Iris (Author) , Gressner, Axel M. (Author) ,


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