Spatial distribution and long-term alterations of peripheral nerve lesions in schwannomatosis
Purpose: To examine the spatial distribution and long-term alterations of peripheral nerve lesions in patients with schwannomatosis by in vivo high-resolution magnetic resonance neurography (MRN). Methods: In this prospective study, the lumbosacral plexus as well as the right sciatic, tibial, and pe...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 March 2022
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| In: |
Diagnostics
Year: 2022, Jahrgang: 12, Heft: 4, Pages: 1-11 |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics12040780 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/diagnostics12040780 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2075-4418/12/4/780 
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| Verfasserangaben: | Tim Godel, Philipp Bäumer, Said Farschtschi, Barbara Hofstadler, Sabine Heiland, Mathias Gelderblom, Martin Bendszus and Victor-Felix Mautner |
MARC
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| 245 | 1 | 0 | |a Spatial distribution and long-term alterations of peripheral nerve lesions in schwannomatosis |c Tim Godel, Philipp Bäumer, Said Farschtschi, Barbara Hofstadler, Sabine Heiland, Mathias Gelderblom, Martin Bendszus and Victor-Felix Mautner |
| 246 | 3 | 0 | |a The diagnostic value of nerve and muscle ultrasound in neuromuscular disorders |
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| 520 | |a Purpose: To examine the spatial distribution and long-term alterations of peripheral nerve lesions in patients with schwannomatosis by in vivo high-resolution magnetic resonance neurography (MRN). Methods: In this prospective study, the lumbosacral plexus as well as the right sciatic, tibial, and peroneal nerves were examined in 15 patients diagnosed with schwannomatosis by a standardized MRN protocol at 3 Tesla. Micro-, intermediate- and macrolesions were assessed according to their number, diameter and spatial distribution. Moreover, in nine patients, peripheral nerve lesions were compared to follow-up examinations after 39 to 71 months. Results: In comparison to intermediate and macrolesions, microlesions were the predominant lesion entity at the level of the proximal (p < 0.001), mid- (p < 0.001), and distal thigh (p < 0.01). Compared to the proximal calf level, the lesion number was increased at the proximal (p < 0.05), mid- (p < 0.01), and distal thigh level (p < 0.01), while between the different thigh levels, no differences in lesion numbers were found. In the follow-up examinations, the lesion number was unchanged for micro-, intermediate and macrolesions. The diameter of lesions in the follow-up examination was decreased for microlesions (p < 0.01), not different for intermediate lesions, and increased for macrolesions (p < 0.01). Conclusion: Microlesions represent the predominant type of peripheral nerve lesion in schwannomatosis and show a rather consistent distribution pattern in long-term follow-up. In contrast to the accumulation of nerve lesions, primarily in the distal nerve segments in NF2, the lesion numbers in schwannomatosis peak at the mid-thigh level. Towards more distal portions, the lesion number markedly decreases, which is considered as a general feature of other types of small fiber neuropathy. | ||
| 650 | 4 | |a magnetic resonance neurography | |
| 650 | 4 | |a peripheral nerve lesions | |
| 650 | 4 | |a schwannomatosis | |
| 650 | 4 | |a small fiber neuropathy | |
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