Cover Image

Spontaneous polarization and cell guidance on asymmetric nanotopography

Asymmetric nanotopography with sub-cellular dimensions has recently demonstrated the ability to provide a unidirectional bias in cell migration. The details of this guidance depend on the type of cell studied and the design of the nanotopography. This behavior is not yet well understood, so there is...

Full description

Saved in:
Bibliographic Details
Main Authors: Herr, Corey (Author) , Winkler, Benjamin (Author) , Ziebert, Falko (Author) , Aranson, Igor S. (Author) , Fourkas, John T. (Author) , Losert, Wolfgang (Author)
Format: Article (Journal)
Language:English
Published: 11 May 2022
In: Communications Physics
Year: 2022, Volume: 5, Pages: 1-8
ISSN:2399-3650
DOI:10.1038/s42005-022-00889-0
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s42005-022-00889-0
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s42005-022-00889-0
Get full text
Author Notes:Corey Herr, Benjamin Winkler, Falko Ziebert, Igor S. Aranson, John T. Fourkas & Wolfgang Losert

MARC

LEADER 00000caa a2200000 c 4500
001 1807574482
003 DE-627
005 20220820203913.0
007 cr uuu---uuuuu
008 220623s2022 xx |||||o 00| ||eng c
024 7 |a 10.1038/s42005-022-00889-0  |2 doi 
035 |a (DE-627)1807574482 
035 |a (DE-599)KXP1807574482 
035 |a (OCoLC)1341461657 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 29  |2 sdnb 
100 1 |a Herr, Corey  |e VerfasserIn  |0 (DE-588)1260696480  |0 (DE-627)1807576175  |4 aut 
245 1 0 |a Spontaneous polarization and cell guidance on asymmetric nanotopography  |c Corey Herr, Benjamin Winkler, Falko Ziebert, Igor S. Aranson, John T. Fourkas & Wolfgang Losert 
264 1 |c 11 May 2022 
300 |a 8 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 23.06.2022 
520 |a Asymmetric nanotopography with sub-cellular dimensions has recently demonstrated the ability to provide a unidirectional bias in cell migration. The details of this guidance depend on the type of cell studied and the design of the nanotopography. This behavior is not yet well understood, so there is a need for a predictive description of cell migration on such nanotopography that captures both the initiation of migration, and the way cell migration evolves. Here, we employ a three-dimensional, physics-based model to study cell guidance on asymmetric nanosawteeth. In agreement with experimental data, our model predicts that asymmetric sawteeth lead to spontaneous motion. Our model demonstrates that the nanosawteeth induce a unidirectional bias in guidance direction that is dependent upon actin polymerization rate and sawtooth dimensions. Motivated by this model, an analysis of previously reported experimental data indicates that the degree of guidance by asymmetric nanosawteeth increases with the cell velocity. 
650 4 |a Cellular motility 
650 4 |a Computational biophysics 
700 1 |a Winkler, Benjamin  |e VerfasserIn  |4 aut 
700 1 |a Ziebert, Falko  |d 1976-  |e VerfasserIn  |0 (DE-588)1147603618  |0 (DE-627)100634750X  |0 (DE-576)495886017  |4 aut 
700 1 |a Aranson, Igor S.  |e VerfasserIn  |4 aut 
700 1 |a Fourkas, John T.  |e VerfasserIn  |4 aut 
700 1 |a Losert, Wolfgang  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Communications Physics  |d London : Springer Nature, 2018  |g 5(2022), Artikel-ID 114, Seite 1-8  |h Online-Ressource  |w (DE-627)1015215459  |w (DE-600)2921913-9  |w (DE-576)500380597  |x 2399-3650  |7 nnas  |a Spontaneous polarization and cell guidance on asymmetric nanotopography 
773 1 8 |g volume:5  |g year:2022  |g elocationid:114  |g pages:1-8  |g extent:8  |a Spontaneous polarization and cell guidance on asymmetric nanotopography 
856 4 0 |u https://doi.org/10.1038/s42005-022-00889-0  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.nature.com/articles/s42005-022-00889-0  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20220623 
993 |a Article 
994 |a 2022 
998 |g 1147603618  |a Ziebert, Falko  |m 1147603618:Ziebert, Falko  |d 130000  |d 130000  |d 130300  |e 130000PZ1147603618  |e 130000PZ1147603618  |e 130300PZ1147603618  |k 0/130000/  |k 0/130000/  |k 1/130000/130300/  |p 3 
999 |a KXP-PPN1807574482  |e 4155281163 
BIB |a Y 
SER |a journal 
JSO |a {"origin":[{"dateIssuedDisp":"11 May 2022","dateIssuedKey":"2022"}],"id":{"doi":["10.1038/s42005-022-00889-0"],"eki":["1807574482"]},"person":[{"display":"Herr, Corey","role":"aut","family":"Herr","given":"Corey"},{"given":"Benjamin","display":"Winkler, Benjamin","role":"aut","family":"Winkler"},{"family":"Ziebert","display":"Ziebert, Falko","role":"aut","given":"Falko"},{"display":"Aranson, Igor S.","role":"aut","family":"Aranson","given":"Igor S."},{"display":"Fourkas, John T.","role":"aut","family":"Fourkas","given":"John T."},{"role":"aut","display":"Losert, Wolfgang","family":"Losert","given":"Wolfgang"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title":"Spontaneous polarization and cell guidance on asymmetric nanotopography","title_sort":"Spontaneous polarization and cell guidance on asymmetric nanotopography"}],"name":{"displayForm":["Corey Herr, Benjamin Winkler, Falko Ziebert, Igor S. Aranson, John T. Fourkas & Wolfgang Losert"]},"physDesc":[{"extent":"8 S."}],"recId":"1807574482","relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title":"Communications Physics","title_sort":"Communications Physics"}],"disp":"Spontaneous polarization and cell guidance on asymmetric nanotopographyCommunications Physics","origin":[{"dateIssuedDisp":"[2018]-","publisher":"Springer Nature","publisherPlace":"London"}],"id":{"eki":["1015215459"],"issn":["2399-3650"],"zdb":["2921913-9"]},"part":{"extent":"8","volume":"5","pages":"1-8","year":"2022","text":"5(2022), Artikel-ID 114, Seite 1-8"},"pubHistory":["1 (2018)-"],"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"recId":"1015215459"}],"note":["Gesehen am 23.06.2022"],"language":["eng"]} 
SRT |a HERRCOREYWSPONTANEOU1120 

Similar Items