Cover Image

Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells

Mutations in IDH1 and IDH2 drive the development of gliomas. These genetic alterations promote tumor cell renewal, disrupt differentiation states, and induce stem-like properties. Understanding how this phenotypic reprogramming occurs remains an area of high interest in glioma research. Previously,...

Full description

Saved in:
Bibliographic Details
Main Authors: Haddock, Sara (Author) , Alban, Tyler J. (Author) , Turcan, S̨evin (Author) , Husic, Hana (Author) , Rosiek, Eric (Author) , Ma, Xiaoxiao (Author) , Wang, Yuxiang (Author) , Bale, Tejus (Author) , Desrichard, Alexis (Author) , Makarov, Vladimir (Author) , Monette, Sebastien (Author) , Wu, Wei (Author) , Gardner, Rui (Author) , Manova, Katia (Author) , Boire, Adrienne (Author) , Chan, Timothy A. (Author)
Format: Article (Journal)
Language:English
Published: June 2022
In: Neoplasia
Year: 2022, Volume: 28, Pages: 1-14
ISSN:1476-5586
DOI:10.1016/j.neo.2022.100790
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neo.2022.100790
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1476558622000197
Get full text
Author Notes:Sara Haddock; Tyler J. Alban; Şevin Turcan; Hana Husic; Eric Rosiek; Xiaoxiao Ma; Yuxiang Wang; Tejus Bale; Alexis Desrichard; Vladimir Makarov; Sebastien Monette; Wei Wu; Rui Gardner; Katia Manova; Adrienne Boire; Timothy A. Chan

MARC

LEADER 00000caa a2200000 c 4500
001 1807814939
003 DE-627
005 20220820204716.0
007 cr uuu---uuuuu
008 220624s2022 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.neo.2022.100790  |2 doi 
035 |a (DE-627)1807814939 
035 |a (DE-599)KXP1807814939 
035 |a (OCoLC)1341461761 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Haddock, Sara  |e VerfasserIn  |0 (DE-588)1260798194  |0 (DE-627)1807814572  |4 aut 
245 1 0 |a Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells  |c Sara Haddock; Tyler J. Alban; Şevin Turcan; Hana Husic; Eric Rosiek; Xiaoxiao Ma; Yuxiang Wang; Tejus Bale; Alexis Desrichard; Vladimir Makarov; Sebastien Monette; Wei Wu; Rui Gardner; Katia Manova; Adrienne Boire; Timothy A. Chan 
246 3 3 |a Phenotypic and molecular states of IDH one mutation-induced CD twenty-four -positive glioma stem-like cells 
264 1 |c June 2022 
300 |a 14 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Available online 7 April 2022 
500 |a Gesehen am 24.06.2022 
520 |a Mutations in IDH1 and IDH2 drive the development of gliomas. These genetic alterations promote tumor cell renewal, disrupt differentiation states, and induce stem-like properties. Understanding how this phenotypic reprogramming occurs remains an area of high interest in glioma research. Previously, we showed that IDH mutation results in the development of a CD24-positive cell population in gliomas. Here, we demonstrate that this CD24-positive population possesses striking stem-like properties at the molecular and phenotypic levels. We found that CD24 expression is associated with stem-like features in IDH-mutant tumors, a patient-derived gliomasphere model, and a neural stem cell model of IDH1-mutant glioma. In orthotopic models, CD24-positive cells display enhanced tumor initiating potency compared to CD24-negative cells. Furthermore, CD24 knockdown results in changes in cell viability, proliferation rate, and gene expression that closely resemble a CD24-negative phenotype. Our data demonstrate that induction of a CD24-positive population is one mechanism by which IDH-mutant tumors acquire stem-like properties. These findings have significant implications for our understanding of the molecular underpinnings of IDH-mutant gliomas. 
650 4 |a cancer stem cells 
650 4 |a CD24 
650 4 |a IDH1 mutation 
650 4 |a Low-grade glioma 
650 4 |a Neural stem cells 
650 4 |a Orthotopic mouse model 
700 1 |a Alban, Tyler J.  |e VerfasserIn  |4 aut 
700 1 |a Turcan, S̨evin  |e VerfasserIn  |0 (DE-588)1167189582  |0 (DE-627)103087414X  |0 (DE-576)511022093  |4 aut 
700 1 |a Husic, Hana  |e VerfasserIn  |4 aut 
700 1 |a Rosiek, Eric  |e VerfasserIn  |4 aut 
700 1 |a Ma, Xiaoxiao  |e VerfasserIn  |4 aut 
700 1 |a Wang, Yuxiang  |e VerfasserIn  |4 aut 
700 1 |a Bale, Tejus  |e VerfasserIn  |4 aut 
700 1 |a Desrichard, Alexis  |e VerfasserIn  |4 aut 
700 1 |a Makarov, Vladimir  |e VerfasserIn  |4 aut 
700 1 |a Monette, Sebastien  |e VerfasserIn  |4 aut 
700 1 |a Wu, Wei  |e VerfasserIn  |4 aut 
700 1 |a Gardner, Rui  |e VerfasserIn  |4 aut 
700 1 |a Manova, Katia  |e VerfasserIn  |4 aut 
700 1 |a Boire, Adrienne  |e VerfasserIn  |4 aut 
700 1 |a Chan, Timothy A.  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Neoplasia  |d Basingstoke : Stockton Press, 1999  |g 28(2022), Artikel-ID 100790, Seite 1-14  |h Online-Ressource  |w (DE-627)320468690  |w (DE-600)2008231-9  |w (DE-576)273878247  |x 1476-5586  |7 nnas  |a Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells 
773 1 8 |g volume:28  |g year:2022  |g elocationid:100790  |g pages:1-14  |g extent:14  |a Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells 
856 4 0 |u https://doi.org/10.1016/j.neo.2022.100790  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S1476558622000197  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20220624 
993 |a Article 
994 |a 2022 
998 |g 1167189582  |a Turcan, S̨evin  |m 1167189582:Turcan, S̨evin  |d 910000  |d 911100  |e 910000PT1167189582  |e 911100PT1167189582  |k 0/910000/  |k 1/910000/911100/  |p 3 
999 |a KXP-PPN1807814939  |e 4156380556 
BIB |a Y 
SER |a journal 
JSO |a {"name":{"displayForm":["Sara Haddock; Tyler J. Alban; Şevin Turcan; Hana Husic; Eric Rosiek; Xiaoxiao Ma; Yuxiang Wang; Tejus Bale; Alexis Desrichard; Vladimir Makarov; Sebastien Monette; Wei Wu; Rui Gardner; Katia Manova; Adrienne Boire; Timothy A. Chan"]},"origin":[{"dateIssuedDisp":"June 2022","dateIssuedKey":"2022"}],"id":{"doi":["10.1016/j.neo.2022.100790"],"eki":["1807814939"]},"physDesc":[{"extent":"14 S."}],"relHost":[{"id":{"eki":["320468690"],"zdb":["2008231-9"],"issn":["1476-5586"]},"origin":[{"publisherPlace":"Basingstoke","dateIssuedKey":"1999","publisher":"Stockton Press","dateIssuedDisp":"1999-"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Neoplasia","title_sort":"Neoplasia"}],"recId":"320468690","language":["eng"],"disp":"Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cellsNeoplasia","type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 08.07.20"],"part":{"extent":"14","volume":"28","text":"28(2022), Artikel-ID 100790, Seite 1-14","pages":"1-14","year":"2022"},"pubHistory":["1.1999 -"]}],"person":[{"family":"Haddock","given":"Sara","display":"Haddock, Sara","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Alban, Tyler J.","role":"aut","family":"Alban","given":"Tyler J."},{"role":"aut","display":"Turcan, S̨evin","roleDisplay":"VerfasserIn","given":"S̨evin","family":"Turcan"},{"given":"Hana","family":"Husic","role":"aut","roleDisplay":"VerfasserIn","display":"Husic, Hana"},{"role":"aut","display":"Rosiek, Eric","roleDisplay":"VerfasserIn","given":"Eric","family":"Rosiek"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Ma, Xiaoxiao","given":"Xiaoxiao","family":"Ma"},{"family":"Wang","given":"Yuxiang","display":"Wang, Yuxiang","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Bale","given":"Tejus","roleDisplay":"VerfasserIn","display":"Bale, Tejus","role":"aut"},{"role":"aut","display":"Desrichard, Alexis","roleDisplay":"VerfasserIn","given":"Alexis","family":"Desrichard"},{"family":"Makarov","given":"Vladimir","roleDisplay":"VerfasserIn","display":"Makarov, Vladimir","role":"aut"},{"given":"Sebastien","family":"Monette","role":"aut","roleDisplay":"VerfasserIn","display":"Monette, Sebastien"},{"given":"Wei","family":"Wu","role":"aut","display":"Wu, Wei","roleDisplay":"VerfasserIn"},{"family":"Gardner","given":"Rui","display":"Gardner, Rui","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Manova","given":"Katia","display":"Manova, Katia","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Boire, Adrienne","given":"Adrienne","family":"Boire"},{"roleDisplay":"VerfasserIn","display":"Chan, Timothy A.","role":"aut","family":"Chan","given":"Timothy A."}],"title":[{"title_sort":"Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells","title":"Phenotypic and molecular states of IDH1 mutation-induced CD24-positive glioma stem-like cells"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Available online 7 April 2022","Gesehen am 24.06.2022"],"language":["eng"],"recId":"1807814939","titleAlt":[{"title":"Phenotypic and molecular states of IDH one mutation-induced CD twenty-four -positive glioma stem-like cells"}]} 
SRT |a HADDOCKSARPHENOTYPIC2022 

Similar Items