Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection
The recent emergence of highly transmissible SARS-CoV-2 variants illustrates the urgent need to better understand the molecular details of the virus binding to its host cell and to develop anti-viral strategies. While many studies focused on the role of the angiotensin-converting enzyme 2 receptor i...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
10 May 2022
|
| In: |
Nature Communications
Year: 2022, Volume: 13, Pages: 1-12 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-022-30313-8 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-022-30313-8 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-022-30313-8 
|
| Author Notes: | Simon J.L. Petitjean, Wenzhang Chen, Melanie Koehler, Ravikumar Jimmidi, Jinsung Yang, Danahe Mohammed, Blinera Juniku, Megan L. Stanifer, Steeve Boulant, Stéphane P. Vincent & David Alsteens |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1807839095 | ||
| 003 | DE-627 | ||
| 005 | 20230426062337.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220627s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-022-30313-8 |2 doi | |
| 035 | |a (DE-627)1807839095 | ||
| 035 | |a (DE-599)KXP1807839095 | ||
| 035 | |a (OCoLC)1341461494 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Petitjean, Simon J. L. |e VerfasserIn |0 (DE-588)126099810X |0 (DE-627)1807840166 |4 aut | |
| 245 | 1 | 0 | |a Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection |c Simon J.L. Petitjean, Wenzhang Chen, Melanie Koehler, Ravikumar Jimmidi, Jinsung Yang, Danahe Mohammed, Blinera Juniku, Megan L. Stanifer, Steeve Boulant, Stéphane P. Vincent & David Alsteens |
| 264 | 1 | |c 10 May 2022 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 27.06.2022 | ||
| 520 | |a The recent emergence of highly transmissible SARS-CoV-2 variants illustrates the urgent need to better understand the molecular details of the virus binding to its host cell and to develop anti-viral strategies. While many studies focused on the role of the angiotensin-converting enzyme 2 receptor in the infection, others suggest the important role of cell attachment factors such as glycans. Here, we use atomic force microscopy to study these early binding events with the focus on the role of sialic acids (SA). We show that SARS-CoV-2 binds specifically to 9-O-acetylated-SA with a moderate affinity, supporting its role as an attachment factor during virus landing to cell host surfaces. For therapeutic purposes and based on this finding, we have designed novel blocking molecules with various topologies and carrying a controlled number of SA residues, enhancing affinity through a multivalent effect. Inhibition assays show that the AcSA-derived glycoclusters are potent inhibitors of cell binding and infectivity, offering new perspectives in the treatment of SARS-CoV-2 infection. | ||
| 650 | 4 | |a Applications of AFM | |
| 650 | 4 | |a Nanoscale biophysics | |
| 650 | 4 | |a SARS-CoV-2 | |
| 700 | 1 | |a Chen, Wenzhang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Koehler, Melanie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jimmidi, Ravikumar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yang, Jinsung |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mohammed, Danahe |e VerfasserIn |4 aut | |
| 700 | 1 | |a Juniku, Blinera |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stanifer, Megan |e VerfasserIn |0 (DE-588)1130687643 |0 (DE-627)884888835 |0 (DE-576)486922367 |4 aut | |
| 700 | 1 | |a Boulant, Steeve |e VerfasserIn |0 (DE-588)1130687430 |0 (DE-627)884888509 |0 (DE-576)48692243X |4 aut | |
| 700 | 1 | |a Vincent, Stéphane P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Alsteens, David |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature Communications |d [London] : Springer Nature, 2010 |g 13(2022), Artikel-ID 2564, Seite 1-12 |h Online-Ressource |w (DE-627)626457688 |w (DE-600)2553671-0 |w (DE-576)331555905 |x 2041-1723 |7 nnas |a Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection |
| 773 | 1 | 8 | |g volume:13 |g year:2022 |g elocationid:2564 |g pages:1-12 |g extent:12 |a Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41467-022-30313-8 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41467-022-30313-8 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220627 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1130687430 |a Boulant, Steeve |m 1130687430:Boulant, Steeve |d 50000 |e 50000PB1130687430 |k 0/50000/ |p 9 | ||
| 998 | |g 1130687643 |a Stanifer, Megan |m 1130687643:Stanifer, Megan |d 50000 |e 50000PS1130687643 |k 0/50000/ |p 8 | ||
| 999 | |a KXP-PPN1807839095 |e 4156717429 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection","title_sort":"Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection"}],"language":["eng"],"person":[{"role":"aut","given":"Simon J. L.","display":"Petitjean, Simon J. L.","family":"Petitjean"},{"role":"aut","given":"Wenzhang","display":"Chen, Wenzhang","family":"Chen"},{"display":"Koehler, Melanie","role":"aut","given":"Melanie","family":"Koehler"},{"display":"Jimmidi, Ravikumar","given":"Ravikumar","role":"aut","family":"Jimmidi"},{"family":"Yang","display":"Yang, Jinsung","role":"aut","given":"Jinsung"},{"display":"Mohammed, Danahe","given":"Danahe","role":"aut","family":"Mohammed"},{"family":"Juniku","given":"Blinera","role":"aut","display":"Juniku, Blinera"},{"family":"Stanifer","display":"Stanifer, Megan","role":"aut","given":"Megan"},{"family":"Boulant","display":"Boulant, Steeve","role":"aut","given":"Steeve"},{"family":"Vincent","role":"aut","given":"Stéphane P.","display":"Vincent, Stéphane P."},{"family":"Alsteens","display":"Alsteens, David","given":"David","role":"aut"}],"name":{"displayForm":["Simon J.L. Petitjean, Wenzhang Chen, Melanie Koehler, Ravikumar Jimmidi, Jinsung Yang, Danahe Mohammed, Blinera Juniku, Megan L. Stanifer, Steeve Boulant, Stéphane P. Vincent & David Alsteens"]},"id":{"eki":["1807839095"],"doi":["10.1038/s41467-022-30313-8"]},"physDesc":[{"extent":"12 S."}],"note":["Gesehen am 27.06.2022"],"relHost":[{"note":["Gesehen am 13.06.24"],"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2553671-0"],"issn":["2041-1723"],"eki":["626457688"]},"disp":"Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infectionNature Communications","origin":[{"publisher":"Springer Nature ; Nature Publishing Group UK","dateIssuedDisp":"[2010]-","publisherPlace":"[London] ; [London]"}],"recId":"626457688","type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["2010-"],"language":["eng"],"part":{"text":"13(2022), Artikel-ID 2564, Seite 1-12","year":"2022","volume":"13","extent":"12","pages":"1-12"},"title":[{"title_sort":"Nature Communications","title":"Nature Communications"}]}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"10 May 2022"}],"recId":"1807839095"} | ||
| SRT | |a PETITJEANSMULTIVALEN1020 | ||