Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody

Activating mutations of the serine threonine kinase v-RAF murine sarcoma viral oncogene homolog B1 (BRAF) are frequent in benign and malignant human tumors and are emerging as an important biomarker. Over 95% of BRAF mutations are of the V600E type and specific small molecular inhibitors are current...

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Bibliographic Details

Main Authors:	Capper, David (Author) , Preusser, Matthias (Author) , Habel, Antje (Author) , Sahm, Felix (Author) , Ackermann, Ulrike (Author) , Schindler, Genevieve (Author) , Pusch, Stefan (Author) , Mechtersheimer, Gunhild (Author) , Zentgraf, Hanswalter (Author) , Deimling, Andreas von (Author)
Format:	Article (Journal)
Language:	English
Published:	03 June 2011
In:	Acta neuropathologica Year: 2011, Volume: 122, Pages: 11-19
ISSN:	1432-0533
DOI:	10.1007/s00401-011-0841-z
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00401-011-0841-z
Author Notes:	David Capper, Matthias Preusser, Antje Habel, Felix Sahm, Ulrike Ackermann, Genevieve Schindler, Stefan Pusch, Gunhild Mechtersheimer, Hanswalter Zentgraf, Andreas von Deimling