The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice
Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release. Here we show that the liver-specific microRNA miR-122 is important for regulating Hamp mRNA expr...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 1, 2011
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| In: |
The journal of clinical investigation
Year: 2011, Jahrgang: 121, Heft: 4, Pages: 1386-1396 |
| ISSN: | 1558-8238 |
| DOI: | 10.1172/JCI44883 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1172/JCI44883 Verlag, lizenzpflichtig, Volltext: https://www.jci.org/articles/view/44883 |
| Verfasserangaben: | Mirco Castoldi, Maja Vujic Spasic, Sandro Altamura, Joacim Elmén, Morten Lindow, Judit Kiss, Jens Stolte, Richard Sparla, Lorenza A. D’Alessandro, Ursula Klingmüller, Robert E. Fleming, Thomas Longerich, Hermann J. Gröne, Vladimir Benes, Sakari Kauppinen, Matthias W. Hentze, and Martina U. Muckenthaler |
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