Modulation of chemokine production and expression of adhesion molecules in renal tubular epithelial and endothelial cells by catecholamines
BACKGROUND: The present study was conducted to investigate whether catecholamines influence the production of chemokines and adhesion molecules in proximal tubular epithelial cells (PTECs) and endothelial cells. METHODS: PTECs and human umbilical vein endothelial cells (HUVECs) were stimulated with...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2002
|
| In: |
Transplantation
Year: 2002, Jahrgang: 74, Heft: 2, Pages: 253-260 |
| ISSN: | 1534-6080 |
| DOI: | 10.1097/00007890-200207270-00017 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/00007890-200207270-00017 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/transplantjournal/Fulltext/2002/07270/Modulation_of_chemokine_production_and_expression.17.aspx 
|
| Verfasserangaben: | Silke Kapper, Grietje Beck, Saskia Riedel, Katharina Prem, Markus Haak, Fokko J. van der Woude and Benito A. Yard |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1808522095 | ||
| 003 | DE-627 | ||
| 005 | 20230713142110.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220629s2002 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1097/00007890-200207270-00017 |2 doi | |
| 035 | |a (DE-627)1808522095 | ||
| 035 | |a (DE-599)KXP1808522095 | ||
| 035 | |a (OCoLC)1341461801 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kapper, Silke |e VerfasserIn |0 (DE-588)1261342453 |0 (DE-627)1808524128 |4 aut | |
| 245 | 1 | 0 | |a Modulation of chemokine production and expression of adhesion molecules in renal tubular epithelial and endothelial cells by catecholamines |c Silke Kapper, Grietje Beck, Saskia Riedel, Katharina Prem, Markus Haak, Fokko J. van der Woude and Benito A. Yard |
| 264 | 1 | |c 2002 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 29.06.2022 | ||
| 520 | |a BACKGROUND: The present study was conducted to investigate whether catecholamines influence the production of chemokines and adhesion molecules in proximal tubular epithelial cells (PTECs) and endothelial cells. METHODS: PTECs and human umbilical vein endothelial cells (HUVECs) were stimulated with various concentrations of dopamine (DA), adrenaline (AD), or noradrenaline (NA), and the production of interleukin (IL)-8, ENA-78, and Gro-alpha was assessed by ELISA. The influence of catecholamine pretreatment on tumor necrosis factor (TNF)-alpha-mediated production of these chemokines and the expression of adhesion molecules was also tested. RESULTS: In PTECs, DA inhibited the production of all three chemokines in a dose-dependent fashion. Although inhibition in ENA-78 and Gro-alpha production was also found in HUVECs, IL-8 production was up-regulated in these cells. Increased IL-8 secretion was predominantly observed at the apical site of the cells. In AD or NA stimulated cells, the production of Gro-alpha was increased in PTECs and decreased in HUVECs. Down-regulation in IL-8 production was also observed after AD but not after NA stimulation of both cell types. Interestingly, TNF-alpha-mediated up-regulation in intercellular adhesion molecule 1, vascular cell adhesion molecule (VCAM), and E-selectin was delayed in DA-pretreated HUVECs but not in PTECs. The influence of DA, but not AD or NA, on chemokine production was completely prevented by the addition of N-acetylcysteine. CONCLUSIONS: This study demonstrates that catecholamines differentially influence chemokine production and indicates that DA may have anti-inflammatory properties because it delays the expression of adhesion molecules and inhibits the production of chemokines in PTECs and endothelial cells under basal and inflammatory conditions. | ||
| 650 | 4 | |a Catecholamines | |
| 650 | 4 | |a Cell Adhesion Molecules | |
| 650 | 4 | |a Cells, Cultured | |
| 650 | 4 | |a Chemokines | |
| 650 | 4 | |a Dopamine | |
| 650 | 4 | |a E-Selectin | |
| 650 | 4 | |a Endothelium, Vascular | |
| 650 | 4 | |a Epithelial Cells | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Intercellular Adhesion Molecule-1 | |
| 650 | 4 | |a Kidney Tubules | |
| 650 | 4 | |a Tumor Necrosis Factor-alpha | |
| 650 | 4 | |a Vascular Cell Adhesion Molecule-1 | |
| 700 | 1 | |a Beck, Grietje |d 1965- |e VerfasserIn |0 (DE-588)114399360 |0 (DE-627)647300117 |0 (DE-576)337555028 |4 aut | |
| 700 | 1 | |a Riedel, Saskia |d 1979- |e VerfasserIn |0 (DE-588)130122378 |0 (DE-627)491710887 |0 (DE-576)298010089 |4 aut | |
| 700 | 1 | |a Prem, Katharina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Haak, Markus |e VerfasserIn |0 (DE-588)1261361377 |0 (DE-627)1808547039 |4 aut | |
| 700 | 1 | |a Woude, Fokko J. van der |d 1953-2006 |e VerfasserIn |0 (DE-588)173440835 |0 (DE-627)698355067 |0 (DE-576)134286820 |4 aut | |
| 700 | 1 | |a Yard, Benito A. |d 1961- |e VerfasserIn |0 (DE-588)1025110633 |0 (DE-627)721145892 |0 (DE-576)369951735 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Transplantation |d Hagerstown, Md. : Lippincott Williams & Wilkins, 1963 |g 74(2002), 2, Seite 253-260 |h Online-Ressource |w (DE-627)32529738X |w (DE-600)2035395-9 |w (DE-576)097188794 |x 1534-6080 |7 nnas |a Modulation of chemokine production and expression of adhesion molecules in renal tubular epithelial and endothelial cells by catecholamines |
| 773 | 1 | 8 | |g volume:74 |g year:2002 |g number:2 |g pages:253-260 |g extent:8 |a Modulation of chemokine production and expression of adhesion molecules in renal tubular epithelial and endothelial cells by catecholamines |
| 856 | 4 | 0 | |u https://doi.org/10.1097/00007890-200207270-00017 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://journals.lww.com/transplantjournal/Fulltext/2002/07270/Modulation_of_chemokine_production_and_expression.17.aspx |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220629 | ||
| 993 | |a Article | ||
| 994 | |a 2002 | ||
| 998 | |g 1025110633 |a Yard, Benito A. |m 1025110633:Yard, Benito A. |d 60000 |d 61400 |e 60000PY1025110633 |e 61400PY1025110633 |k 0/60000/ |k 1/60000/61400/ |p 7 |y j | ||
| 998 | |g 173440835 |a Woude, Fokko J. van der |m 173440835:Woude, Fokko J. van der |d 60000 |d 61400 |e 60000PW173440835 |e 61400PW173440835 |k 0/60000/ |k 1/60000/61400/ |p 6 | ||
| 998 | |g 1261361377 |a Haak, Markus |m 1261361377:Haak, Markus |d 60000 |d 61400 |e 60000PH1261361377 |e 61400PH1261361377 |k 0/60000/ |k 1/60000/61400/ |p 5 | ||
| 998 | |g 130122378 |a Riedel, Saskia |m 130122378:Riedel, Saskia |d 60000 |d 61400 |e 60000PR130122378 |e 61400PR130122378 |k 0/60000/ |k 1/60000/61400/ |p 3 | ||
| 998 | |g 114399360 |a Beck, Grietje |m 114399360:Beck, Grietje |d 60000 |d 61600 |e 60000PB114399360 |e 61600PB114399360 |k 0/60000/ |k 1/60000/61600/ |p 2 | ||
| 998 | |g 1261342453 |a Kapper, Silke |m 1261342453:Kapper, Silke |d 60000 |d 61400 |e 60000PK1261342453 |e 61400PK1261342453 |k 0/60000/ |k 1/60000/61400/ |p 1 |x j | ||
| 999 | |a KXP-PPN1808522095 |e 4158502055 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Kapper, Silke","given":"Silke","family":"Kapper","role":"aut"},{"display":"Beck, Grietje","given":"Grietje","family":"Beck","role":"aut"},{"display":"Riedel, Saskia","given":"Saskia","role":"aut","family":"Riedel"},{"display":"Prem, Katharina","given":"Katharina","role":"aut","family":"Prem"},{"family":"Haak","role":"aut","display":"Haak, Markus","given":"Markus"},{"display":"Woude, Fokko J. van der","given":"Fokko J. van der","family":"Woude","role":"aut"},{"display":"Yard, Benito A.","given":"Benito A.","family":"Yard","role":"aut"}],"recId":"1808522095","note":["Gesehen am 29.06.2022"],"name":{"displayForm":["Silke Kapper, Grietje Beck, Saskia Riedel, Katharina Prem, Markus Haak, Fokko J. van der Woude and Benito A. Yard"]},"language":["eng"],"relHost":[{"recId":"32529738X","title":[{"title_sort":"Transplantation","subtitle":"the official journal of the Transplantation Society","title":"Transplantation"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1534-6080"],"eki":["32529738X"],"zdb":["2035395-9"]},"origin":[{"publisher":"Lippincott Williams & Wilkins ; Ovid","dateIssuedDisp":"1963-","dateIssuedKey":"1963","publisherPlace":"Hagerstown, Md. ; [Erscheinungsort nicht ermittelbar]"}],"language":["eng"],"part":{"volume":"74","year":"2002","text":"74(2002), 2, Seite 253-260","issue":"2","pages":"253-260","extent":"8"},"pubHistory":["1.1963 -"],"note":["Gesehen am 11.06.2019"],"corporate":[{"display":"Transplantation Society","role":"isb"}],"disp":"Modulation of chemokine production and expression of adhesion molecules in renal tubular epithelial and endothelial cells by catecholaminesTransplantation","type":{"bibl":"periodical","media":"Online-Ressource"}}],"origin":[{"dateIssuedKey":"2002","dateIssuedDisp":"2002"}],"title":[{"title":"Modulation of chemokine production and expression of adhesion molecules in renal tubular epithelial and endothelial cells by catecholamines","title_sort":"Modulation of chemokine production and expression of adhesion molecules in renal tubular epithelial and endothelial cells by catecholamines"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"8 S."}],"id":{"eki":["1808522095"],"doi":["10.1097/00007890-200207270-00017"]}} | ||
| SRT | |a KAPPERSILKMODULATION2002 | ||