Preoperative hydronephrosis predicts advanced bladder cancer but is not an independent factor for cancer-specific survival after radical cystectomy
Introduction: Hydronephrosis and BMI are analyzed together with established factors such as TNM stage and surgical margins in a multivariate modality to investigate their status as independent prognostic factors for bladder cancer-specific survival in patients undergoing radical cystectomy. Patients...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2011
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| In: |
Urologia internationalis
Year: 2011, Volume: 86, Issue: 1, Pages: 25-30 |
| ISSN: | 1423-0399 |
| DOI: | 10.1159/000321008 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000321008 Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/321008 
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| Author Notes: | Thomas Hofner, Axel Haferkamp, Lena Knapp, Sascha Pahernik, Boris Hadaschik, Nenad Djakovic, Nina Wagener, Markus Hohenfellner |
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| 245 | 1 | 0 | |a Preoperative hydronephrosis predicts advanced bladder cancer but is not an independent factor for cancer-specific survival after radical cystectomy |c Thomas Hofner, Axel Haferkamp, Lena Knapp, Sascha Pahernik, Boris Hadaschik, Nenad Djakovic, Nina Wagener, Markus Hohenfellner |
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| 520 | |a Introduction: Hydronephrosis and BMI are analyzed together with established factors such as TNM stage and surgical margins in a multivariate modality to investigate their status as independent prognostic factors for bladder cancer-specific survival in patients undergoing radical cystectomy. Patients and Methods: We studied a prospective cohort of 328 patients who underwent radical cystectomy for bladder cancer at our institution. Statistical analyses were performed using the Kaplan-Meier method, Kendall-tau rank correlation and multivariate Cox proportional hazard model. Results: Hydronephrosis was positively correlated with advanced tumor stage, positive lymph node involvement and positive surgical margins. Adjusted for all other investigated parameters, BMI and hydronephrosis did not affect cancer-specific survival. In multivariate analysis only non-organ-confined disease (HR: 1.40, 95% CI: 1.04-1.87, p = 0.024), positive lymph node stage (HR 1.71: 95% CI: 1.12-2.61, p = 0.013) and positive surgical margins (HR 3.00, 95% CI: 1.74-5.15, p < 0.001) were prognostic factors. Conclusions: Hydronephrosis at the time of radical cystectomy is significantly correlated with the presence of more advanced bladder cancer and positive surgical margins. However, the long-established parameters pT stage, pN stage and surgical margins predominantly influence cancer-specific survival for patients undergoing radical cystectomy irrespective of hydronephrosis and BMI status. | ||
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