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Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target

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Main Authors: Lechner, Severin (Author) , Malgapo, Martin Ian P. (Author) , Grätz, Christian (Author) , Steimbach, Raphael R. (Author) , Baron, Agnes (Author) , Rüther, Patrick (Author) , Nadal, Simon (Author) , Stumpf, Carmen (Author) , Loos, Christina (Author) , Ku, Xin (Author) , Prokofeva, Polina (Author) , Lautenbacher, Ludwig (Author) , Heimburg, Tino (Author) , Würf, Vivian (Author) , Meng, Chen (Author) , Wilhelm, Mathias (Author) , Sippl, Wolfgang (Author) , Kleigrewe, Karin (Author) , Pauling, Josch K. (Author) , Kramer, Karl (Author) , Miller, Aubry K. (Author) , Pfaffl, Michael W. (Author) , Linder, Maurine E. (Author) , Kuster, Bernhard (Author) , Médard, Guillaume (Author)
Format: Article (Journal)
Language:English
Published: 28 April 2022
In: Nature chemical biology
Year: 2022, Volume: 18, Pages: 812-820
ISSN:1552-4469
DOI:10.1038/s41589-022-01015-5
Online Access:Resolving-System, lizenzpflichtig: https://doi.org/10.1038/s41589-022-01015-5
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Author Notes:Severin Lechner, Martin Ian P. Malgapo, Christian Grätz, Raphael R. Steimbach, Agnes Baron, Patrick Rüther, Simon Nadal, Carmen Stumpf, Christina Loos, Xin Ku, Polina Prokofeva, Ludwig Lautenbacher, Tino Heimburg, Vivian Würf, Chen Meng, Mathias Wilhelm, Wolfgang Sippl, Karin Kleigrewe, Josch K. Pauling, Karl Kramer, Aubry K. Miller, Michael W. Pfaffl, Maurine E. Linder, Bernhard Kuster and Guillaume Médard

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