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Peripheral and intracerebral T cell immune response in cats naturally infected with Borna disease virus

Borna disease virus (BDV) is a neurotropic agent with capacity to cause encephalomyelitis in a wide range of animal species, including horses and cats. Recent studies also point to a link between BDV and human neuropsychiatric disorders. The pathogenesis of Borna disease (BD) has been proposed to be...

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Hauptverfasser: Berg, Anna-Lena (VerfasserIn) , Johannisson, A. (VerfasserIn) , Johansson, M. (VerfasserIn) , Hein, Andreas (VerfasserIn) , Berg, M. (VerfasserIn) , Dörries, Rüdiger (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2 June 1999
In: Veterinary immunology and immunopathology
Year: 1999, Jahrgang: 68, Heft: 2, Pages: 241-253
ISSN:1873-2534
DOI:10.1016/S0165-2427(99)00030-6
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0165-2427(99)00030-6
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165242799000306
Volltext
Verfasserangaben:A-L Berg, A. Johannisson, M. Johansson, A. Hein, M. Berg, R. Dörries
Beschreibung
Zusammenfassung:Borna disease virus (BDV) is a neurotropic agent with capacity to cause encephalomyelitis in a wide range of animal species, including horses and cats. Recent studies also point to a link between BDV and human neuropsychiatric disorders. The pathogenesis of Borna disease (BD) has been proposed to be immune-mediated, mainly through the effects of cytotoxic T cells. We used flow cytometric analysis in order to characterize the peripheral and intracerebral T cell immune response in cats naturally infected with BDV. Our results show the presence of two different CD8+ cell populations (CD8+low and CD8+high) in the blood, spleen and brain of these cats. In the brain, CD8+low cells predominated over CD8+high cells. Since CD8+low cells have been suggested to represent a non-MHC-restricted T cell population, the recruitment of such cells to the brains of BDV-infected cats could possibly be of importance for the clearance of virus from neurones.
Beschreibung:Gesehen am 30.06.2022
Beschreibung:Online Resource
ISSN:1873-2534
DOI:10.1016/S0165-2427(99)00030-6

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