Buchumschlag

The genomic and transcriptional landscape of primary central nervous system lymphoma

Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of PCNSL have not been fully elucidated. Here, we profile and compare the whole-genome and transcriptome landscape of 51 CNS lymp...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Radke, Josefine (VerfasserIn) , Ishaque, Naveed (VerfasserIn) , Koll, Randi (VerfasserIn) , Gu, Zuguang (VerfasserIn) , Schumann, Elisa (VerfasserIn) , Sieverling, Lina (VerfasserIn) , Uhrig, Sebastian (VerfasserIn) , Hübschmann, Daniel (VerfasserIn) , Toprak, Umut (VerfasserIn) , López, Cristina (VerfasserIn) , Hostench, Xavier Pastor (VerfasserIn) , Borgoni, Simone (VerfasserIn) , Juraeva, Dilafruz (VerfasserIn) , Pritsch, Fabienne (VerfasserIn) , Paramasivam, Nagarajan (VerfasserIn) , Balasubramanian, Gnana Prakash (VerfasserIn) , Schlesner, Matthias (VerfasserIn) , Sahay, Shashwat (VerfasserIn) , Weniger, Marc (VerfasserIn) , Pehl, Debora (VerfasserIn) , Radbruch, Helena (VerfasserIn) , Osterloh, Anja (VerfasserIn) , Korfel, Agnieszka (VerfasserIn) , Misch, Martin (VerfasserIn) , Onken, Julia (VerfasserIn) , Faust, Katharina (VerfasserIn) , Vajkoczy, Peter (VerfasserIn) , Moskopp, Dag (VerfasserIn) , Wang, Yawen (VerfasserIn) , Jödicke, Andreas (VerfasserIn) , Trümper, Lorenz (VerfasserIn) , Anagnostopoulos, Ioannis (VerfasserIn) , Lenze, Dido (VerfasserIn) , Küppers, Ralf (VerfasserIn) , Hummel, Michael (VerfasserIn) , Schmitt, Clemens Alexander (VerfasserIn) , Wiestler, Otmar D. (VerfasserIn) , Wolf, Stephan (VerfasserIn) , Unterberg, Andreas (VerfasserIn) , Eils, Roland (VerfasserIn) , Herold-Mende, Christel (VerfasserIn) , Brors, Benedikt (VerfasserIn) , Siebert, Reiner (VerfasserIn) , Wiemann, Stefan (VerfasserIn) , Heppner, Frank L. (VerfasserIn) , Lichter, Peter (VerfasserIn) , Radlwimmer, Bernhard (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 10 May 2022
In: Nature Communications
Year: 2022, Jahrgang: 13, Pages: 1-20
ISSN:2041-1723
DOI:10.1038/s41467-022-30050-y
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-022-30050-y
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-022-30050-y
Volltext
Verfasserangaben:Josefine Radke, Naveed Ishaque, Randi Koll, Zuguang Gu, Elisa Schumann, Lina Sieverling, Sebastian Uhrig, Daniel Hübschmann, Umut H. Toprak, Cristina López, Xavier Pastor Hostench, Simone Borgoni, Dilafruz Juraeva, Fabienne Pritsch, Nagarajan Paramasivam, Gnana Prakash Balasubramanian, Matthias Schlesner, Shashwat Sahay, Marc Weniger, Debora Pehl, Helena Radbruch, Anja Osterloh, Agnieszka Korfel, Martin Misch, Julia Onken, Katharina Faust, Peter Vajkoczy, Dag Moskopp, Yawen Wang, Andreas Jödicke, Lorenz Trümper, Ioannis Anagnostopoulos, Dido Lenze, Ralf Küppers, Michael Hummel, Clemens A. Schmitt, Otmar D. Wiestler, Stephan Wolf, Andreas Unterberg, Roland Eils, Christel Herold-Mende, Benedikt Brors, Reiner Siebert, Stefan Wiemann, Frank L. Heppner, Peter Lichter,

MARC

LEADER 00000caa a2200000 c 4500
001 1808750535
003 DE-627
005 20230417154854.0
007 cr uuu---uuuuu
008 220701s2022 xx |||||o 00| ||eng c
024 7 |a 10.1038/s41467-022-30050-y  |2 doi 
035 |a (DE-627)1808750535 
035 |a (DE-599)KXP1808750535 
035 |a (OCoLC)1341463414 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Radke, Josefine  |e VerfasserIn  |0 (DE-588)1013125606  |0 (DE-627)663354730  |0 (DE-576)346564409  |4 aut 
245 1 4 |a The genomic and transcriptional landscape of primary central nervous system lymphoma  |c Josefine Radke, Naveed Ishaque, Randi Koll, Zuguang Gu, Elisa Schumann, Lina Sieverling, Sebastian Uhrig, Daniel Hübschmann, Umut H. Toprak, Cristina López, Xavier Pastor Hostench, Simone Borgoni, Dilafruz Juraeva, Fabienne Pritsch, Nagarajan Paramasivam, Gnana Prakash Balasubramanian, Matthias Schlesner, Shashwat Sahay, Marc Weniger, Debora Pehl, Helena Radbruch, Anja Osterloh, Agnieszka Korfel, Martin Misch, Julia Onken, Katharina Faust, Peter Vajkoczy, Dag Moskopp, Yawen Wang, Andreas Jödicke, Lorenz Trümper, Ioannis Anagnostopoulos, Dido Lenze, Ralf Küppers, Michael Hummel, Clemens A. Schmitt, Otmar D. Wiestler, Stephan Wolf, Andreas Unterberg, Roland Eils, Christel Herold-Mende, Benedikt Brors, Reiner Siebert, Stefan Wiemann, Frank L. Heppner, Peter Lichter, 
264 1 |c 10 May 2022 
300 |a 20 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 01.07.2022 
520 |a Primary lymphomas of the central nervous system (PCNSL) are mainly diffuse large B-cell lymphomas (DLBCLs) confined to the central nervous system (CNS). Molecular drivers of PCNSL have not been fully elucidated. Here, we profile and compare the whole-genome and transcriptome landscape of 51 CNS lymphomas (CNSL) to 39 follicular lymphoma and 36 DLBCL cases outside the CNS. We find recurrent mutations in JAK-STAT, NFkB, and B-cell receptor signaling pathways, including hallmark mutations in MYD88 L265P (67%) and CD79B (63%), and CDKN2A deletions (83%). PCNSLs exhibit significantly more focal deletions of HLA-D (6p21) locus as a potential mechanism of immune evasion. Mutational signatures correlating with DNA replication and mitosis are significantly enriched in PCNSL. TERT gene expression is significantly higher in PCNSL compared to activated B-cell (ABC)-DLBCL. Transcriptome analysis clearly distinguishes PCNSL and systemic DLBCL into distinct molecular subtypes. Epstein-Barr virus (EBV)+ CNSL cases lack recurrent mutational hotspots apart from IG and HLA-DRB loci. We show that PCNSL can be clearly distinguished from DLBCL, having distinct expression profiles, IG expression and translocation patterns, as well as specific combinations of genetic alterations. 
650 4 |a B-cell lymphoma 
650 4 |a Cancer genomics 
650 4 |a CNS cancer 
700 1 |a Ishaque, Naveed  |e VerfasserIn  |4 aut 
700 1 |a Koll, Randi  |e VerfasserIn  |4 aut 
700 1 |a Gu, Zuguang  |e VerfasserIn  |4 aut 
700 1 |a Schumann, Elisa  |e VerfasserIn  |4 aut 
700 1 |a Sieverling, Lina  |e VerfasserIn  |4 aut 
700 1 |a Uhrig, Sebastian  |e VerfasserIn  |4 aut 
700 1 |a Hübschmann, Daniel  |d 1981-  |e VerfasserIn  |0 (DE-588)1099133653  |0 (DE-627)858143798  |0 (DE-576)469237082  |4 aut 
700 1 |a Toprak, Umut  |d 1986-  |e VerfasserIn  |0 (DE-588)1201204429  |0 (DE-627)1684659019  |4 aut 
700 1 |a López, Cristina  |e VerfasserIn  |4 aut 
700 1 |a Hostench, Xavier Pastor  |e VerfasserIn  |4 aut 
700 1 |a Borgoni, Simone  |e VerfasserIn  |4 aut 
700 1 |a Juraeva, Dilafruz  |e VerfasserIn  |4 aut 
700 1 |a Pritsch, Fabienne  |e VerfasserIn  |4 aut 
700 1 |a Paramasivam, Nagarajan  |e VerfasserIn  |4 aut 
700 1 |a Balasubramanian, Gnana Prakash  |e VerfasserIn  |4 aut 
700 1 |a Schlesner, Matthias  |d 1978-  |e VerfasserIn  |0 (DE-588)138455201  |0 (DE-627)602593867  |0 (DE-576)307654656  |4 aut 
700 1 |a Sahay, Shashwat  |e VerfasserIn  |4 aut 
700 1 |a Weniger, Marc  |e VerfasserIn  |4 aut 
700 1 |a Pehl, Debora  |e VerfasserIn  |4 aut 
700 1 |a Radbruch, Helena  |e VerfasserIn  |4 aut 
700 1 |a Osterloh, Anja  |e VerfasserIn  |4 aut 
700 1 |a Korfel, Agnieszka  |e VerfasserIn  |4 aut 
700 1 |a Misch, Martin  |e VerfasserIn  |4 aut 
700 1 |a Onken, Julia  |e VerfasserIn  |4 aut 
700 1 |a Faust, Katharina  |e VerfasserIn  |4 aut 
700 1 |a Vajkoczy, Peter  |e VerfasserIn  |4 aut 
700 1 |a Moskopp, Dag  |e VerfasserIn  |4 aut 
700 1 |a Wang, Yawen  |e VerfasserIn  |4 aut 
700 1 |a Jödicke, Andreas  |e VerfasserIn  |4 aut 
700 1 |a Trümper, Lorenz  |e VerfasserIn  |4 aut 
700 1 |a Anagnostopoulos, Ioannis  |e VerfasserIn  |4 aut 
700 1 |a Lenze, Dido  |e VerfasserIn  |4 aut 
700 1 |a Küppers, Ralf  |e VerfasserIn  |4 aut 
700 1 |a Hummel, Michael  |e VerfasserIn  |4 aut 
700 1 |a Schmitt, Clemens Alexander  |d 1967-  |e VerfasserIn  |0 (DE-588)128538767  |0 (DE-627)374217114  |0 (DE-576)297202901  |4 aut 
700 1 |a Wiestler, Otmar D.  |d 1956-  |e VerfasserIn  |0 (DE-588)133387372  |0 (DE-627)544041887  |0 (DE-576)299813401  |4 aut 
700 1 |a Wolf, Stephan  |e VerfasserIn  |0 (DE-588)1109104146  |0 (DE-627)864250371  |0 (DE-576)475545141  |4 aut 
700 1 |a Unterberg, Andreas  |e VerfasserIn  |0 (DE-588)1032681187  |0 (DE-627)738641200  |0 (DE-576)168441233  |4 aut 
700 1 |a Eils, Roland  |d 1965-  |e VerfasserIn  |0 (DE-588)1020648287  |0 (DE-627)691291705  |0 (DE-576)361718195  |4 aut 
700 1 |a Herold-Mende, Christel  |e VerfasserIn  |0 (DE-588)1022936549  |0 (DE-627)717335577  |0 (DE-576)366194267  |4 aut 
700 1 |a Brors, Benedikt  |e VerfasserIn  |0 (DE-588)1112102965  |0 (DE-627)866068732  |0 (DE-576)476376157  |4 aut 
700 1 |a Siebert, Reiner  |e VerfasserIn  |4 aut 
700 1 |a Wiemann, Stefan  |e VerfasserIn  |0 (DE-588)1105581209  |0 (DE-627)862699134  |0 (DE-576)473627191  |4 aut 
700 1 |a Heppner, Frank L.  |e VerfasserIn  |4 aut 
700 1 |a Lichter, Peter  |d 1957-  |e VerfasserIn  |0 (DE-588)1096366282  |0 (DE-627)856749915  |0 (DE-576)468019049  |4 aut 
700 1 |a Radlwimmer, Bernhard  |e VerfasserIn  |0 (DE-588)1078935513  |0 (DE-627)839825560  |0 (DE-576)452084423  |4 aut 
773 0 8 |i Enthalten in  |t Nature Communications  |d [London] : Springer Nature, 2010  |g 13(2022), Artikel-ID 2558, Seite 1-20  |h Online-Ressource  |w (DE-627)626457688  |w (DE-600)2553671-0  |w (DE-576)331555905  |x 2041-1723  |7 nnas  |a The genomic and transcriptional landscape of primary central nervous system lymphoma 
773 1 8 |g volume:13  |g year:2022  |g elocationid:2558  |g pages:1-20  |g extent:20  |a The genomic and transcriptional landscape of primary central nervous system lymphoma 
856 4 0 |u https://doi.org/10.1038/s41467-022-30050-y  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.nature.com/articles/s41467-022-30050-y  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20220701 
993 |a Article 
994 |a 2022 
998 |g 1078935513  |a Radlwimmer, Bernhard  |m 1078935513:Radlwimmer, Bernhard  |d 50000  |e 50000PR1078935513  |k 0/50000/ 
998 |g 1096366282  |a Lichter, Peter  |m 1096366282:Lichter, Peter  |d 50000  |e 50000PL1096366282  |k 0/50000/ 
998 |g 1105581209  |a Wiemann, Stefan  |m 1105581209:Wiemann, Stefan  |d 140000  |e 140000PW1105581209  |k 0/140000/  |p 44 
998 |g 1112102965  |a Brors, Benedikt  |m 1112102965:Brors, Benedikt  |d 140000  |e 140000PB1112102965  |k 0/140000/  |p 42 
998 |g 1022936549  |a Herold-Mende, Christel  |m 1022936549:Herold-Mende, Christel  |d 910000  |d 911200  |e 910000PH1022936549  |e 911200PH1022936549  |k 0/910000/  |k 1/910000/911200/  |p 41 
998 |g 1020648287  |a Eils, Roland  |m 1020648287:Eils, Roland  |d 910000  |d 911800  |d 50000  |e 910000PE1020648287  |e 911800PE1020648287  |e 50000PE1020648287  |k 0/910000/  |k 1/910000/911800/  |k 0/50000/  |p 40 
998 |g 1032681187  |a Unterberg, Andreas  |m 1032681187:Unterberg, Andreas  |d 910000  |d 911200  |e 910000PU1032681187  |e 911200PU1032681187  |k 0/910000/  |k 1/910000/911200/  |p 39 
998 |g 1109104146  |a Wolf, Stephan  |m 1109104146:Wolf, Stephan  |d 50000  |e 50000PW1109104146  |k 0/50000/  |p 38 
998 |g 138455201  |a Schlesner, Matthias  |m 138455201:Schlesner, Matthias  |d 140000  |e 140000PS138455201  |k 0/140000/  |p 17 
998 |g 1201204429  |a Toprak, Umut  |m 1201204429:Toprak, Umut  |d 50000  |e 50000PT1201204429  |k 0/50000/  |p 9 
998 |g 1099133653  |a Hübschmann, Daniel  |m 1099133653:Hübschmann, Daniel  |d 50000  |e 50000PH1099133653  |k 0/50000/  |p 8 
999 |a KXP-PPN1808750535  |e 4159992323 
BIB |a Y 
SER |a journal 
JSO |a {"person":[{"family":"Radke","display":"Radke, Josefine","given":"Josefine","role":"aut"},{"given":"Naveed","display":"Ishaque, Naveed","family":"Ishaque","role":"aut"},{"role":"aut","family":"Koll","display":"Koll, Randi","given":"Randi"},{"role":"aut","family":"Gu","display":"Gu, Zuguang","given":"Zuguang"},{"role":"aut","display":"Schumann, Elisa","given":"Elisa","family":"Schumann"},{"display":"Sieverling, Lina","given":"Lina","family":"Sieverling","role":"aut"},{"role":"aut","given":"Sebastian","display":"Uhrig, Sebastian","family":"Uhrig"},{"given":"Daniel","display":"Hübschmann, Daniel","family":"Hübschmann","role":"aut"},{"family":"Toprak","display":"Toprak, Umut","given":"Umut","role":"aut"},{"role":"aut","display":"López, Cristina","given":"Cristina","family":"López"},{"given":"Xavier Pastor","display":"Hostench, Xavier Pastor","family":"Hostench","role":"aut"},{"role":"aut","family":"Borgoni","display":"Borgoni, Simone","given":"Simone"},{"role":"aut","given":"Dilafruz","display":"Juraeva, Dilafruz","family":"Juraeva"},{"role":"aut","given":"Fabienne","display":"Pritsch, Fabienne","family":"Pritsch"},{"family":"Paramasivam","display":"Paramasivam, Nagarajan","given":"Nagarajan","role":"aut"},{"role":"aut","family":"Balasubramanian","display":"Balasubramanian, Gnana Prakash","given":"Gnana Prakash"},{"display":"Schlesner, Matthias","given":"Matthias","family":"Schlesner","role":"aut"},{"given":"Shashwat","display":"Sahay, Shashwat","family":"Sahay","role":"aut"},{"family":"Weniger","display":"Weniger, Marc","given":"Marc","role":"aut"},{"display":"Pehl, Debora","given":"Debora","family":"Pehl","role":"aut"},{"role":"aut","family":"Radbruch","display":"Radbruch, Helena","given":"Helena"},{"role":"aut","family":"Osterloh","given":"Anja","display":"Osterloh, Anja"},{"role":"aut","display":"Korfel, Agnieszka","given":"Agnieszka","family":"Korfel"},{"role":"aut","family":"Misch","given":"Martin","display":"Misch, Martin"},{"given":"Julia","display":"Onken, Julia","family":"Onken","role":"aut"},{"family":"Faust","given":"Katharina","display":"Faust, Katharina","role":"aut"},{"role":"aut","family":"Vajkoczy","given":"Peter","display":"Vajkoczy, Peter"},{"role":"aut","family":"Moskopp","given":"Dag","display":"Moskopp, Dag"},{"display":"Wang, Yawen","given":"Yawen","family":"Wang","role":"aut"},{"role":"aut","family":"Jödicke","display":"Jödicke, Andreas","given":"Andreas"},{"role":"aut","given":"Lorenz","display":"Trümper, Lorenz","family":"Trümper"},{"given":"Ioannis","display":"Anagnostopoulos, Ioannis","family":"Anagnostopoulos","role":"aut"},{"role":"aut","family":"Lenze","given":"Dido","display":"Lenze, Dido"},{"display":"Küppers, Ralf","given":"Ralf","family":"Küppers","role":"aut"},{"role":"aut","given":"Michael","display":"Hummel, Michael","family":"Hummel"},{"role":"aut","family":"Schmitt","display":"Schmitt, Clemens Alexander","given":"Clemens Alexander"},{"role":"aut","given":"Otmar D.","display":"Wiestler, Otmar D.","family":"Wiestler"},{"role":"aut","display":"Wolf, Stephan","given":"Stephan","family":"Wolf"},{"role":"aut","display":"Unterberg, Andreas","given":"Andreas","family":"Unterberg"},{"display":"Eils, Roland","given":"Roland","family":"Eils","role":"aut"},{"role":"aut","family":"Herold-Mende","given":"Christel","display":"Herold-Mende, Christel"},{"role":"aut","given":"Benedikt","display":"Brors, Benedikt","family":"Brors"},{"family":"Siebert","display":"Siebert, Reiner","given":"Reiner","role":"aut"},{"display":"Wiemann, Stefan","given":"Stefan","family":"Wiemann","role":"aut"},{"family":"Heppner","display":"Heppner, Frank L.","given":"Frank L.","role":"aut"},{"family":"Lichter","display":"Lichter, Peter","given":"Peter","role":"aut"},{"role":"aut","display":"Radlwimmer, Bernhard","given":"Bernhard","family":"Radlwimmer"}],"name":{"displayForm":["Josefine Radke, Naveed Ishaque, Randi Koll, Zuguang Gu, Elisa Schumann, Lina Sieverling, Sebastian Uhrig, Daniel Hübschmann, Umut H. Toprak, Cristina López, Xavier Pastor Hostench, Simone Borgoni, Dilafruz Juraeva, Fabienne Pritsch, Nagarajan Paramasivam, Gnana Prakash Balasubramanian, Matthias Schlesner, Shashwat Sahay, Marc Weniger, Debora Pehl, Helena Radbruch, Anja Osterloh, Agnieszka Korfel, Martin Misch, Julia Onken, Katharina Faust, Peter Vajkoczy, Dag Moskopp, Yawen Wang, Andreas Jödicke, Lorenz Trümper, Ioannis Anagnostopoulos, Dido Lenze, Ralf Küppers, Michael Hummel, Clemens A. Schmitt, Otmar D. Wiestler, Stephan Wolf, Andreas Unterberg, Roland Eils, Christel Herold-Mende, Benedikt Brors, Reiner Siebert, Stefan Wiemann, Frank L. Heppner, Peter Lichter,"]},"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"10 May 2022"}],"recId":"1808750535","title":[{"title":"The genomic and transcriptional landscape of primary central nervous system lymphoma","title_sort":"genomic and transcriptional landscape of primary central nervous system lymphoma"}],"language":["eng"],"physDesc":[{"extent":"20 S."}],"id":{"doi":["10.1038/s41467-022-30050-y"],"eki":["1808750535"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 01.07.2022"],"relHost":[{"language":["eng"],"recId":"626457688","disp":"The genomic and transcriptional landscape of primary central nervous system lymphomaNature Communications","type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["2010-"],"title":[{"title_sort":"Nature Communications","title":"Nature Communications"}],"origin":[{"publisherPlace":"[London] ; [London]","publisher":"Springer Nature ; Nature Publishing Group UK","dateIssuedDisp":"[2010]-"}],"note":["Gesehen am 13.06.24"],"physDesc":[{"extent":"Online-Ressource"}],"part":{"year":"2022","extent":"20","pages":"1-20","volume":"13","text":"13(2022), Artikel-ID 2558, Seite 1-20"},"id":{"eki":["626457688"],"issn":["2041-1723"],"zdb":["2553671-0"]}}]} 
SRT |a RADKEJOSEFGENOMICAND1020 

Ähnliche Einträge