Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy
Autophagy mediates lysosomal degradation of cytosolic components. Recent work has associated autophagic dysfunction with pathologies, including cancer and cardiovascular disease. To date, the identification of clinically-applicable drugs that modulate autophagy has been hampered by the lack of stand...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
02 June 2011
|
| In: |
BMC biology
Year: 2011, Volume: 9, Pages: 1-15 |
| ISSN: | 1741-7007 |
| DOI: | 10.1186/1741-7007-9-38 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1741-7007-9-38
|
| Author Notes: | Phillip Hundeshagen, Anne Hamacher-Brady, Roland Eils and Nathan R. Brady |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1808772792 | ||
| 003 | DE-627 | ||
| 005 | 20230426090956.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220701s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/1741-7007-9-38 |2 doi | |
| 035 | |a (DE-627)1808772792 | ||
| 035 | |a (DE-599)KXP1808772792 | ||
| 035 | |a (OCoLC)1341463407 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hundeshagen, Phillip |e VerfasserIn |0 (DE-588)1019441771 |0 (DE-627)690900104 |0 (DE-576)358064287 |4 aut | |
| 245 | 1 | 0 | |a Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy |c Phillip Hundeshagen, Anne Hamacher-Brady, Roland Eils and Nathan R. Brady |
| 264 | 1 | |c 02 June 2011 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 01.07.2022 | ||
| 520 | |a Autophagy mediates lysosomal degradation of cytosolic components. Recent work has associated autophagic dysfunction with pathologies, including cancer and cardiovascular disease. To date, the identification of clinically-applicable drugs that modulate autophagy has been hampered by the lack of standardized assays capable of precisely reporting autophagic activity. | ||
| 650 | 4 | |a Cardiac Glycoside | |
| 650 | 4 | |a Digoxin | |
| 650 | 4 | |a Nutrient Deprivation | |
| 650 | 4 | |a Rapamycin | |
| 650 | 4 | |a Resveratrol | |
| 700 | 1 | |a Hamacher-Brady, Anne |e VerfasserIn |0 (DE-588)132378884 |0 (DE-627)52194693X |0 (DE-576)299109054 |4 aut | |
| 700 | 1 | |a Eils, Roland |d 1965- |e VerfasserIn |0 (DE-588)1020648287 |0 (DE-627)691291705 |0 (DE-576)361718195 |4 aut | |
| 700 | 1 | |a Brady, Nathan |e VerfasserIn |0 (DE-588)1075765625 |0 (DE-627)833820230 |0 (DE-576)444637591 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t BMC biology |d Berlin : Springer, 2003 |g 9(2011), Artikel-ID 38, Seite 1-15 |h Online-Ressource |w (DE-627)377757241 |w (DE-600)2133020-7 |w (DE-576)121896404 |x 1741-7007 |7 nnas |a Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy |
| 773 | 1 | 8 | |g volume:9 |g year:2011 |g elocationid:38 |g pages:1-15 |g extent:15 |a Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy |
| 856 | 4 | 0 | |u https://doi.org/10.1186/1741-7007-9-38 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220701 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 1075765625 |a Brady, Nathan |m 1075765625:Brady, Nathan |d 700000 |d 716000 |e 700000PB1075765625 |e 716000PB1075765625 |k 0/700000/ |k 1/700000/716000/ |p 4 |y j | ||
| 998 | |g 1020648287 |a Eils, Roland |m 1020648287:Eils, Roland |d 160000 |d 160100 |e 160000PE1020648287 |e 160100PE1020648287 |k 0/160000/ |k 1/160000/160100/ |p 3 | ||
| 998 | |g 132378884 |a Hamacher-Brady, Anne |m 132378884:Hamacher-Brady, Anne |d 50000 |e 50000PH132378884 |k 0/50000/ |p 2 | ||
| 999 | |a KXP-PPN1808772792 |e 4160009344 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"15 S."}],"language":["eng"],"person":[{"family":"Hundeshagen","given":"Phillip","role":"aut","display":"Hundeshagen, Phillip"},{"family":"Hamacher-Brady","given":"Anne","role":"aut","display":"Hamacher-Brady, Anne"},{"role":"aut","given":"Roland","family":"Eils","display":"Eils, Roland"},{"display":"Brady, Nathan","given":"Nathan","role":"aut","family":"Brady"}],"title":[{"title_sort":"Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy","title":"Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy"}],"name":{"displayForm":["Phillip Hundeshagen, Anne Hamacher-Brady, Roland Eils and Nathan R. Brady"]},"recId":"1808772792","id":{"doi":["10.1186/1741-7007-9-38"],"eki":["1808772792"]},"origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"02 June 2011"}],"note":["Gesehen am 01.07.2022"],"relHost":[{"pubHistory":["1.2003 -"],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 22.05.20"],"title":[{"title":"BMC biology","title_sort":"BMC biology"}],"disp":"Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagyBMC biology","recId":"377757241","part":{"pages":"1-15","volume":"9","extent":"15","text":"9(2011), Artikel-ID 38, Seite 1-15","year":"2011"},"id":{"issn":["1741-7007"],"zdb":["2133020-7"],"eki":["377757241"]},"origin":[{"dateIssuedDisp":"2003-","publisher":"Springer ; BioMed Central","dateIssuedKey":"2003","publisherPlace":"Berlin ; Heidelberg ; London"}]}]} | ||
| SRT | |a HUNDESHAGECONCURRENT0220 | ||