Comparison study of myocardial radiomics feature properties on energy-integrating and photon-counting detector CT

The implementation of radiomics-based, quantitative imaging parameters is hampered by a lack of stability and standardization. Photon-counting computed tomography (PCCT), compared to energy-integrating computed tomography (EICT), does rely on a novel detector technology, promising better spatial res...

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Main Authors: Ayx, Isabelle (Author) , Tharmaseelan, Hishan (Author) , Hertel, Alexander (Author) , Nörenberg, Dominik (Author) , Overhoff, Daniel (Author) , Rotkopf, Lukas Thomas (Author) , Riffel, Philipp (Author) , Schönberg, Stefan (Author) , Froelich, Matthias F. (Author)
Format: Article (Journal)
Language:English
Published: 2022
In: Diagnostics
Year: 2022, Volume: 12, Issue: 5, Pages: 1-11
ISSN:2075-4418
DOI:10.3390/diagnostics12051294
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/diagnostics12051294
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2075-4418/12/5/1294
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Author Notes:Isabelle Ayx, Hishan Tharmaseelan, Alexander Hertel, Dominik Nörenberg, Daniel Overhoff, Lukas T. Rotkopf, Philipp Riffel, Stefan O. Schoenberg and Matthias F. Froelich

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520 |a The implementation of radiomics-based, quantitative imaging parameters is hampered by a lack of stability and standardization. Photon-counting computed tomography (PCCT), compared to energy-integrating computed tomography (EICT), does rely on a novel detector technology, promising better spatial resolution and contrast-to-noise ratio. However, its effect on radiomics feature properties is unknown. This work investigates this topic in myocardial imaging. In this retrospective, single-center IRB-approved study, the left ventricular myocardium was segmented on CT, and the radiomics features were extracted using pyradiomics. To compare features between scanners, a t-test for non-paired samples and F-test was performed, with a threshold of 0.05 set as a benchmark for significance. Feature correlations were calculated by the Pearson correlation coefficient, and visualization was performed with heatmaps. A total of 50 patients (56% male, mean age 56) were enrolled in this study, with equal proportions of PCCT and EICT. First-order features were, nearly, comparable between both groups. However, higher-order features showed a partially significant difference between PCCT and EICT. While first-order radiomics features of left ventricular myocardium show comparability between PCCT and EICT, detected differences of higher-order features may indicate a possible impact of improved spatial resolution, better detection of lower-energy photons, and a better signal-to-noise ratio on texture analysis on PCCT. 
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