Overexpression of ZEB2 at the invasion front of colorectal cancer is an independent prognostic marker and regulates tumor invasion in vitro

Purpose: Epithelial-to-mesenchymal transition (EMT) plays a pivotal role in tumor invasion and dissemination. EMT occurs predominantly at the tumor edge where it is induced by cytokines, the extracellular matrix environment, or hypoxia. In the tumor cell, it is further mediated by several transcript...

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Main Authors:	Kahlert, Christoph (Author) , Lahes, Saleh (Author) , Radhakrishnan, Praveen (Author) , Dutta, Shamik (Author) , Mogler, Carolin (Author) , Herpel, Esther (Author) , Brand, Karsten (Author) , Steinert, Gunnar (Author) , Schneider, Martin (Author) , Mollenhauer, Martin (Author) , Reißfelder, Christoph (Author) , Klupp, Fee (Author) , Fritzmann, Johannes (Author) , Kunz, Christina (Author) , Benner, Axel (Author) , Kloor, Matthias (Author) , Huth, Cathrin (Author) , Contin, Pietro (Author) , Ulrich, Alexis (Author) , Koch, Moritz (Author) , Weitz, Jürgen (Author)
Format:	Article (Journal)
Language:	English
Published:	October 31, 2011
In:	Clinical cancer research Year: 2011, Volume: 17, Issue: 24, Pages: 7654-7663
ISSN:	1557-3265
DOI:	10.1158/1078-0432.CCR-10-2816
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/1078-0432.CCR-10-2816
Author Notes:	Christoph Kahlert, Saleh Lahes, Praveen Radhakrishnan, Shamik Dutta, Carolin Mogler, Esther Herpel, Karsten Brand, Gunnar Steinert, Martin Schneider, Martin Mollenhauer, Christoph Reissfelder, Fee Klupp, Johannes Fritzmann, Christina Wunder, Axel Benner, Matthias Kloor, Cathrin Huth, Pietro Contin, Alexis Ulrich, Moritz Koch, and Jürgen Weitz