Frequency and syndrome specificity of antibodies to aquaporin-4 in neurological patients with rheumatic disorders
Background: A new autoantibody (termed NMO-IgG, or AQP4-Ab) has recently been described in patients with neuromyelitis optica (NMO) and its formes frustes, longitudinally extensive transverse myelitis (LETM) and recurrent optic neuritis (rON). However, AQP4-Ab has been found also in patients with co...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 4, 2011
|
| In: |
Multiple sclerosis journal
Year: 2011, Jahrgang: 17, Heft: 9, Pages: 1067-1073 |
| ISSN: | 1477-0970 |
| DOI: | 10.1177/1352458511403958 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1177/1352458511403958
|
| Verfasserangaben: | Sven Jarius, Christian Jacobi, Jerome de Seze, Helene Zephir, Friedemann Paul, Diego Franciotta, Paulus Rommer, Simone Mader, Ingo Kleiter, Markus Reindl, Gulsen Akman-Demir, Thomas Seifert-Held, Wolfgang Kristoferitsch, Arthur Melms, Klaus-Peter Wandinger and Brigitte Wildemann |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1809051525 | ||
| 003 | DE-627 | ||
| 005 | 20230802171928.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220704s2011 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/1352458511403958 |2 doi | |
| 035 | |a (DE-627)1809051525 | ||
| 035 | |a (DE-599)KXP1809051525 | ||
| 035 | |a (OCoLC)1341463393 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Jarius, Sven |e VerfasserIn |0 (DE-588)1054615918 |0 (DE-627)791654818 |0 (DE-576)410367478 |4 aut | |
| 245 | 1 | 0 | |a Frequency and syndrome specificity of antibodies to aquaporin-4 in neurological patients with rheumatic disorders |c Sven Jarius, Christian Jacobi, Jerome de Seze, Helene Zephir, Friedemann Paul, Diego Franciotta, Paulus Rommer, Simone Mader, Ingo Kleiter, Markus Reindl, Gulsen Akman-Demir, Thomas Seifert-Held, Wolfgang Kristoferitsch, Arthur Melms, Klaus-Peter Wandinger and Brigitte Wildemann |
| 264 | 1 | |c May 4, 2011 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.07.2022 | ||
| 520 | |a Background: A new autoantibody (termed NMO-IgG, or AQP4-Ab) has recently been described in patients with neuromyelitis optica (NMO) and its formes frustes, longitudinally extensive transverse myelitis (LETM) and recurrent optic neuritis (rON). However, AQP4-Ab has been found also in patients with co-existing rheumatic diseases such as systemic lupus erythematosus (SLE) or Sjögren’s syndrome (SS), conditions which are characterized by broad, polyspecific B cell activation., Objectives: In this study, we aimed at evaluating the syndrome specificity and frequency of AQP4-Ab in patients with rheumatic diseases and neurological symptoms., Methods: For this purpose, serum samples from 109 neurological patients with established connective tissue disorders (CTD) (n = 54), possible CTD (n = 42), or vasculitis (n = 13) were analysed for the presence of AQP4-Ab by a cell-based assay employing recombinant human AQP4., Results: AQP4-Ab was detectable in 31/40 (78%) patients with CTD and NMO spectrum disorders (median titre, 1:1000) but in none of the samples obtained from patients with CTD or vasculitis and neurological disorders other than NMO, LETM, or rON (n = 69)., Conclusion: The high syndrome specificity of the antibody for neuromyelitis optica spectrum disorders (NMOSDs) in patients with CTD supports the concept of AQP4-Ab being involved in the pathogenesis of these neurological conditions, and argues against AQP4-Ab simply being part of the polyclonal B cell activation generally associated with rheumatic diseases. Moreover, the finding that AQP4-Ab is present in patients with CTD and co-existing NMOSD with approximately the same frequency as in patients without CTD strengthens the case of CTD and AQP4-Ab positive NMOSD representing two co-existing yet distinct entities in the majority of patients. | ||
| 650 | 4 | |a antibody to aquaporin-4 | |
| 650 | 4 | |a connective tissue disorders | |
| 650 | 4 | |a diagnosis | |
| 650 | 4 | |a longitudinally extensive transverse myelitis | |
| 650 | 4 | |a neuromyelitis optica (Devic’s disease) | |
| 650 | 4 | |a neuropsychiatric lupus | |
| 650 | 4 | |a NMO-IgG | |
| 650 | 4 | |a rheumatic diseases | |
| 650 | 4 | |a scleroderma | |
| 650 | 4 | |a Sjögren’s syndrome | |
| 650 | 4 | |a systemic lupus erythematosus | |
| 650 | 4 | |a vasculitis | |
| 700 | 1 | |a Jacobi, Christian |d 1970- |e VerfasserIn |0 (DE-588)173586023 |0 (DE-627)698496485 |0 (DE-576)134429729 |4 aut | |
| 700 | 1 | |a de Seze, Jerome |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zephir, Helene |e VerfasserIn |4 aut | |
| 700 | 1 | |a Paul, Friedemann |e VerfasserIn |4 aut | |
| 700 | 1 | |a Franciotta, Diego |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rommer, Paulus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mader, Simone |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kleiter, Ingo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Reindl, Markus |e VerfasserIn |0 (DE-588)1158607156 |0 (DE-627)1020597453 |0 (DE-576)504248413 |4 aut | |
| 700 | 1 | |a Akman-Demir, Gulsen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Seifert-Held, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kristoferitsch, Wolfgang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Melms, Arthur |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wandinger, Klaus-Peter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wildemann, Brigitte |e VerfasserIn |0 (DE-588)110203844 |0 (DE-627)510150004 |0 (DE-576)171831330 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Multiple sclerosis journal |d London : Sage, 1995 |g 17(2011), 9, Seite 1067-1073 |h Online-Ressource |w (DE-627)320468658 |w (DE-600)2008225-3 |w (DE-576)273878239 |x 1477-0970 |7 nnas |a Frequency and syndrome specificity of antibodies to aquaporin-4 in neurological patients with rheumatic disorders |
| 773 | 1 | 8 | |g volume:17 |g year:2011 |g number:9 |g pages:1067-1073 |g extent:7 |a Frequency and syndrome specificity of antibodies to aquaporin-4 in neurological patients with rheumatic disorders |
| 856 | 4 | 0 | |u https://doi.org/10.1177/1352458511403958 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220704 | ||
| 993 | |a Article | ||
| 994 | |a 2011 | ||
| 998 | |g 110203844 |a Wildemann, Brigitte |m 110203844:Wildemann, Brigitte |d 910000 |d 911100 |e 910000PW110203844 |e 911100PW110203844 |k 0/910000/ |k 1/910000/911100/ |p 16 |y j | ||
| 998 | |g 173586023 |a Jacobi, Christian |m 173586023:Jacobi, Christian |d 50000 |e 50000PJ173586023 |k 0/50000/ |p 2 | ||
| 998 | |g 1054615918 |a Jarius, Sven |m 1054615918:Jarius, Sven |d 910000 |d 911100 |e 910000PJ1054615918 |e 911100PJ1054615918 |k 0/910000/ |k 1/910000/911100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1809051525 |e 4160972640 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1809051525","type":{"bibl":"article-journal","media":"Online-Ressource"},"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"issn":["1477-0970"],"eki":["320468658"],"zdb":["2008225-3"]},"disp":"Frequency and syndrome specificity of antibodies to aquaporin-4 in neurological patients with rheumatic disordersMultiple sclerosis journal","recId":"320468658","part":{"pages":"1067-1073","year":"2011","text":"17(2011), 9, Seite 1067-1073","extent":"7","issue":"9","volume":"17"},"titleAlt":[{"title":"Multiple sclerosis"}],"note":["Gesehen am 19.01.11"],"title":[{"title_sort":"Multiple sclerosis journal","title":"Multiple sclerosis journal"}],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"origin":[{"publisher":"Sage ; Stockton ; Nature ; Arnold","dateIssuedDisp":"1995-","dateIssuedKey":"1995","publisherPlace":"London ; Basingstoke, Hampshire ; Basingstoke, Hampshire ; London"}],"pubHistory":["1.1995 -"]}],"name":{"displayForm":["Sven Jarius, Christian Jacobi, Jerome de Seze, Helene Zephir, Friedemann Paul, Diego Franciotta, Paulus Rommer, Simone Mader, Ingo Kleiter, Markus Reindl, Gulsen Akman-Demir, Thomas Seifert-Held, Wolfgang Kristoferitsch, Arthur Melms, Klaus-Peter Wandinger and Brigitte Wildemann"]},"person":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Jarius, Sven","given":"Sven","family":"Jarius"},{"roleDisplay":"VerfasserIn","role":"aut","given":"Christian","family":"Jacobi","display":"Jacobi, Christian"},{"family":"de Seze","given":"Jerome","display":"de Seze, Jerome","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Zephir","given":"Helene","display":"Zephir, Helene","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Paul, Friedemann","given":"Friedemann","family":"Paul","role":"aut","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Franciotta, Diego","given":"Diego","family":"Franciotta"},{"family":"Rommer","given":"Paulus","display":"Rommer, Paulus","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Mader, Simone","given":"Simone","family":"Mader","role":"aut","roleDisplay":"VerfasserIn"},{"family":"Kleiter","given":"Ingo","display":"Kleiter, Ingo","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","role":"aut","family":"Reindl","given":"Markus","display":"Reindl, Markus"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Akman-Demir, Gulsen","family":"Akman-Demir","given":"Gulsen"},{"roleDisplay":"VerfasserIn","role":"aut","family":"Seifert-Held","given":"Thomas","display":"Seifert-Held, Thomas"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Kristoferitsch, Wolfgang","family":"Kristoferitsch","given":"Wolfgang"},{"display":"Melms, Arthur","family":"Melms","given":"Arthur","role":"aut","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Wandinger, Klaus-Peter","given":"Klaus-Peter","family":"Wandinger"},{"given":"Brigitte","family":"Wildemann","display":"Wildemann, Brigitte","roleDisplay":"VerfasserIn","role":"aut"}],"language":["eng"],"origin":[{"dateIssuedDisp":"May 4, 2011","dateIssuedKey":"2011"}],"title":[{"title":"Frequency and syndrome specificity of antibodies to aquaporin-4 in neurological patients with rheumatic disorders","title_sort":"Frequency and syndrome specificity of antibodies to aquaporin-4 in neurological patients with rheumatic disorders"}],"id":{"eki":["1809051525"],"doi":["10.1177/1352458511403958"]},"physDesc":[{"extent":"7 S."}],"note":["Gesehen am 04.07.2022"]} | ||
| SRT | |a JARIUSSVENFREQUENCYA4201 | ||