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Selective bilateral hippocampal lesions after theophylline-induced status epilepticus causes a permanent amnesic syndrome

Theophylline is known to increase the risk of epileptic seizures and might have a role in seizure-induced brain damage. We present a 55-year-old man who developed an amnesic syndrome after status epilepticus, caused by accidental theophylline intoxication. Imaging studies revealed acute, selective b...

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Hauptverfasser: Kohl, Zacharias (VerfasserIn) , Uyanik, G. (VerfasserIn) , Lürding, R. (VerfasserIn) , Schuierer, G. (VerfasserIn) , Bogdahn, U. (VerfasserIn) , Schröder, M. (VerfasserIn) , Weidner, Norbert (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 6 May 2011
In: Journal of clinical neuroscience
Year: 2011, Jahrgang: 18, Heft: 7, Pages: 964-966
ISSN:1532-2653
DOI:10.1016/j.jocn.2010.11.017
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jocn.2010.11.017
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0967586811000099
Volltext
Verfasserangaben:Z. Kohl, G. Uyanik, R. Lürding, G. Schuierer, U. Bogdahn, M. Schröder, N. Weidner
Beschreibung
Zusammenfassung:Theophylline is known to increase the risk of epileptic seizures and might have a role in seizure-induced brain damage. We present a 55-year-old man who developed an amnesic syndrome after status epilepticus, caused by accidental theophylline intoxication. Imaging studies revealed acute, selective bilateral hippocampal damage, which corresponded to severe disturbances in bilateral temporal functions on neuropsychological testing. Three months later, the memory deficits persisted, while imaging exhibited bilateral atrophy of the hippocampus. Upon his long-term, 18-month follow-up, the patient demonstrated improvements in his daily living abilities, despite the persistence of bilateral temporal deficits. This report provides evidence that theophylline has the potential to provoke permanent seizure-induced neural damage, presumably via inhibition of adenosine receptors, and especially in vulnerable regions of the brain, such as the hippocampus.
Beschreibung:Gesehen am 06.07.2022
Beschreibung:Online Resource
ISSN:1532-2653
DOI:10.1016/j.jocn.2010.11.017

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